公开(公告)号：US20220031867A1

公开(公告)日：2022-02-03

申请号：US17280606

申请日：2019-09-30

Applicant: University of Rochester

Inventor： Maiken Nedergaard ,  Benjamin Plog ,  Humberto Mestre

IPC: A61K49/00 ,  A61K9/00 ,  A61K45/06

Abstract: This invention relates to improving delivery of agents to the central nervous system.

公开(公告)号：US20250073354A1

公开(公告)日：2025-03-06

申请号：US18722693

申请日：2022-12-22

Applicant: University of Rochester

Inventor： Maiken Nedergaard ,  Steven A. Goldman

IPC: A61K48/00 ,  A61P27/16 ,  C07K14/47 ,  C12N15/86

Abstract: This disclosure relates compositions and methods to delivery of various agents to the inner ear of a subject.

公开(公告)号：US20250049957A1

公开(公告)日：2025-02-13

申请号：US18722690

申请日：2022-12-22

Applicant: University of Rochester ,  University of Copenhagen ,  Karolinska Institutet

Inventor： Maiken Nedergaard ,  Barbara K. Mathiesen ,  Christopher R. Cederroth ,  Barbara Canlon

IPC: A61K48/00 ,  A61P27/16 ,  C07K14/705 ,  C12N15/86

Abstract: This disclosure relates to delivery of various agents to the inner ear of a subject.

公开(公告)号：US11690876B2

公开(公告)日：2023-07-04

申请号：US16612529

申请日：2018-05-10

Applicant: UNIVERSITY OF ROCHESTER

Inventor： Steven A. Goldman ,  Maiken Nedergaard

IPC: A61K35/30 ,  A61P25/18 ,  A61K31/495 ,  C12N5/0735 ,  C12N5/074 ,  A61K9/00

CPC classification number: A61K35/30 ,  A61K31/495 ,  A61P25/18 ,  C12N5/0606 ,  C12N5/0696 ,  A61K9/007 ,  A61K9/0019 ,  A61K9/0085

Abstract: The present disclosure is directed to a method of treating a neuropsychiatric disorder. This method involves selecting a subject having the neuropsychiatric disorder and administering to the selected subject a preparation of glial progenitor cells at a dosage effective to treat the neuropsychiatric disorder in the subject. Another aspect of the disclosure is directed to a method of treating a neuropsychiatric disorder that includes selecting a subject having the neuropsychiatric disorder and administering, to the selected subject, a potassium (K+) channel activator at a dosage effective to restore normal brain interstitial glial K+ levels in the selected subject and treat the neuropsychiatric disorder is also disclosed.

公开(公告)号：US20220280423A1

公开(公告)日：2022-09-08

申请号：US17699953

申请日：2022-03-21

Applicant: University of Rochester

Inventor： Maiken Nedergaard ,  Benjamin Plog ,  Humberto Mestre ,  Tuomas O. Lilius ,  Andreas I. Jensen ,  Steven A. Goldman

IPC: A61K9/00 ,  A61K47/02 ,  C07K16/18 ,  A61K9/51

Abstract: This invention relates to improving delivery of agents (e.g., one or more nanoparticles) to the central nervous system.

公开(公告)号：US09901650B2

公开(公告)日：2018-02-27

申请号：US14769396

申请日：2014-02-21

Applicant: University of Rochester ,  The Research Foundation for The State University of New York

Inventor： Maiken Nedergaard ,  Jeffrey J. Iliff ,  Helene Benveniste ,  Rashid Deane

IPC: A61K51/04 ,  A61K49/00 ,  A61K31/41 ,  A61K38/10 ,  A61B5/055 ,  A61B5/00 ,  G01N33/68 ,  A61K31/4178 ,  A61K31/437 ,  A61K31/55 ,  A61K31/551 ,  A61K49/06 ,  A61M27/00 ,  A61B6/03

CPC classification number: A61K51/0491 ,  A61B5/055 ,  A61B5/4064 ,  A61B5/4082 ,  A61B6/037 ,  A61B2576/026 ,  A61K31/41 ,  A61K31/4178 ,  A61K31/437 ,  A61K31/55 ,  A61K31/551 ,  A61K38/10 ,  A61K49/0032 ,  A61K49/0054 ,  A61K49/06 ,  A61M27/00 ,  G01N33/6896 ,  G01N2800/2814 ,  G01N2800/50

Abstract: Methods are provided for measuring glio-vascular pathway (“glymphatic system”) function in the brain of a mammal which include performing imaging of the brain and measuring cerebrospinal fluid-interstitial fluid (CSF-ISF) exchange in the brain. The methods can be used to track the exchange between CSF and ISF compartments. An imaging agent is optionally administered intrathecally. The imaging agent can be a negative or positive (paramagnetic) contrast agent and dynamic or contrast-enhanced magnetic resonance imaging (MRI) of the brain can be performed. The imaging agent can be a positron-emitting radionuclide tracer and positron emission tomography (PET) can be performed. Methods for treating diseases or disorders of the mammalian brain are also provided, in which the methods increase or decrease glymphatic clearance.

公开(公告)号：US20160000945A1

公开(公告)日：2016-01-07

申请号：US14769396

申请日：2014-02-21

Applicant: UNIVERSITY OF ROCHESTER ,  THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK

Inventor： Maiken Nedergaard ,  Jeffrey J. Iliff ,  Helene Benveniste ,  Rashid Deane

IPC: A61K51/04 ,  A61K31/55 ,  A61K31/551 ,  G01N33/68 ,  A61K49/06 ,  A61K31/4178 ,  A61K31/437 ,  A61K31/41 ,  A61M27/00 ,  A61K38/10

CPC classification number: A61K51/0491 ,  A61B5/055 ,  A61B5/4064 ,  A61B5/4082 ,  A61B6/037 ,  A61B2576/026 ,  A61K31/41 ,  A61K31/4178 ,  A61K31/437 ,  A61K31/55 ,  A61K31/551 ,  A61K38/10 ,  A61K49/0032 ,  A61K49/0054 ,  A61K49/06 ,  A61M27/00 ,  G01N33/6896 ,  G01N2800/2814 ,  G01N2800/50

Abstract: Methods are provided for measuring glio-vascular pathway (“glymphatic system”) function in the brain of a mammal which include performing imaging of the brain and measuring cerebrospinal fluid-interstitial fluid (CSF-ISF) exchange in the brain. The methods can be used to track the exchange between CSF and ISF compartments. An imaging agent is optionally administered intrathecally. The imaging agent can be a negative or positive (paramagnetic) contrast agent and dynamic or contrast-enhanced magnetic resonance imaging (MRI) of the brain can be performed. The imaging agent can be a positron-emitting radionuclide tracer and positron emission tomography (PET) can be performed. Methods for treating diseases or disorders of the mammalian brain are also provided, in which the methods increase or decrease glymphatic clearance.

Abstract translation: 提供了用于测量哺乳动物脑中的胶质血管通路（“糖质系统”）功能的方法，其包括进行大脑成像并测量脑中的脑脊液 - 间质液（CSF-ISF）交换。 这些方法可用于跟踪CSF和ISF隔间之间的交换。 任选地鞘内施用成像剂。 成像剂可以是阴性或阳性（顺磁性）造影剂，并且可以进行大脑的动态或对比度增强的磁共振成像（MRI）。 成像剂可以是正电子发射放射性核素示踪剂，并且可以进行正电子发射断层摄影（PET）。 还提供了用于治疗哺乳动物脑的疾病或病症的方法，其中所述方法增加或降低了淋巴间隙。