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    Polymer/copper combination for targeted cancer therapy
    2.
    发明授权
    Polymer/copper combination for targeted cancer therapy 有权

    公开(公告)号：US10221271B2

    公开(公告)日：2019-03-05

    申请号：US15783282

    申请日：2017-10-13

    Applicant: University of South Carolina

    Inventor： Peisheng Xu ,  Huacheng He

    IPC: C08F220/28 ,  A61K31/00 ,  A61K31/795 ,  A61K33/34

    Abstract: Polymer/copper combinations that can selectively target and kill cancer cells are described. Materials can include the reaction product of a biocompatible hydrophilic polymer and pyridine-2-thiol containing monomer. The copolymer reaction product can include pyridine-2-thiol side groups pendant to the backbone via a disulfide linkage. The hydrophilic component can form the polymer backbone and/or can form hydrophilic pendant groups off of the backbone. Copper ions can be associated with the copolymer.

    Polymeric prodrug of disulfiram and application thereof
    5.
    发明授权
    Polymeric prodrug of disulfiram and application thereof 有权

    公开(公告)号：US09861704B2

    公开(公告)日：2018-01-09

    申请号：US14962426

    申请日：2015-12-08

    Applicant: University of South Carolina

    Inventor： Peisheng Xu ,  Huacheng He

    IPC: A61K47/48

    CPC classification number: A61K47/59 ,  A61K47/58 ,  A61K47/60

    Abstract: Polymer/drug conjugates that can selectively target and kill cancer cells are described. Conjugates can include a copolymer formed by the reaction of a biocompatible hydrophilic component and a disulfiram derivative. The copolymer reaction product can include additional functional groups pendant to the backbone via a disulfide linkage, for instance copper chelators. The hydrophilic component can form the polymer backbone and/or can form hydrophilic pendant groups off of the backbone. Copper ions can be associated with the copolymer.

    Polymeric Prodrug of Disulfiram and Application Thereof
    6.
    发明申请
    Polymeric Prodrug of Disulfiram and Application Thereof 有权
    双硫仑的聚合前药及其应用

    公开(公告)号：US20160166706A1

    公开(公告)日：2016-06-16

    申请号：US14962426

    申请日：2015-12-08

    Applicant: University of South Carolina

    Inventor： Peisheng Xu ,  Huacheng He

    IPC: A61K47/48 ,  A61K31/145

    CPC classification number: A61K47/59 ,  A61K47/58 ,  A61K47/60

    Abstract: Polymer/drug conjugates that can selectively target and kill cancer cells are described. Conjugates can include a copolymer formed by the reaction of a biocompatible hydrophilic component and a disulfiram derivative. The copolymer reaction product can include additional functional groups pendant to the backbone via a disulfide linkage, for instance copper chelators. The hydrophilic component can form the polymer backbone and/or can form hydrophilic pendant groups off of the backbone. Copper ions can be associated with the copolymer.

    Abstract translation: 描述了可以选择性靶向和杀死癌细胞的聚合物/药物共轭物。 缀合物可以包括通过生物相容的亲水组分与二硫吡喃衍生物的反应形成的共聚物。 共聚物反应产物可以包括通过二硫键垂饰于主链的另外的官能团，例如铜螯合剂。 亲水性组分可以形成聚合物主链和/或可形成脱离主链的亲水侧基。 铜离子可与共聚物缔合。

    Polymer/Copper Combination for Targeted Cancer Therapy
    7.
    发明申请
    Polymer/Copper Combination for Targeted Cancer Therapy 有权
    聚合物/铜组合靶向癌症治疗

    公开(公告)号：US20160108160A1

    公开(公告)日：2016-04-21

    申请号：US14887373

    申请日：2015-10-20

    Applicant: University of South Carolina

    Inventor： Peisheng Xu ,  Huacheng He

    IPC: C08F220/28 ,  A61K31/795

    CPC classification number: C08F220/28 ,  A61K31/00 ,  A61K31/795 ,  A61K33/34 ,  C08F2220/282 ,  A61K2300/00

    Abstract: Polymer/copper combination that can selectively target and kill cancer cells are described. Materials can include the reaction product of a biocompatible hydrophilic polymer and pyridine-2-thiol containing monomer. The copolymer reaction product can include pyridine-2-thiol side groups pendant to the backbone via a disulfide linkage. The hydrophilic component can form the polymer backbone and/or can form hydrophilic pendant groups off of the backbone. Copper ions can be associated with the copolymer.

    Abstract translation: 描述了可选择性靶向和杀死癌细胞的聚合物/铜组合。 材料可以包括生物相容的亲水性聚合物和含吡啶-2-硫醇的单体的反应产物。 共聚物反应产物可以包括通过二硫键悬挂于主链的吡啶-2-硫醇侧基。 亲水性组分可以形成聚合物主链和/或可形成脱离主链的亲水侧基。 铜离子可与共聚物缔合。

    PREPARATIONS OF GOLD/MESOPOROUS SILICA HYBRID NANOPARITCLE AND APPLICATIONS
    8.
    发明申请
    PREPARATIONS OF GOLD/MESOPOROUS SILICA HYBRID NANOPARITCLE AND APPLICATIONS 审中-公开
    黄金/多孔二氧化硅混合纳米粒子的制备及应用

    公开(公告)号：US20160067354A1

    公开(公告)日：2016-03-10

    申请号：US14833711

    申请日：2015-08-24

    Applicant: University of South Carolina

    Inventor： Peisheng Xu ,  Bei Cheng ,  Huacheng He

    IPC: A61K47/48 ,  A61K31/704 ,  A61K51/12 ,  A61K41/00

    CPC classification number: A61K31/704 ,  A61K9/5115 ,  A61K41/0052 ,  A61K51/0482 ,  A61K51/1251

    Abstract: Described is a method to fabricate a gold/mesoporous silica hybrid nanoparticle. According to the process, a gold nanoparticle can be conjugated onto the surface of a mesoporous silica nanoparticle to yield a photothermal stable theranostic platform, gold/mesoporous silica hybrid nanoparticle. The nanoparticles can be useful for disease detection, treatment, and monitoring.

    Abstract translation: 描述了制造金/介孔二氧化硅杂化纳米颗粒的方法。 根据该方法，金纳米颗粒可以结合到介孔二氧化硅纳米颗粒的表面上以产生光热稳定的纳米颗粒平台，金/介孔二氧化硅杂化纳米颗粒。 纳米颗粒可用于疾病检测，治疗和监测。

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