公开(公告)号：US20160008289A1

公开(公告)日：2016-01-14

申请号：US14859661

申请日：2015-09-21

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： Peisheng Xu ,  Remant Bahadur KC

IPC: A61K9/50 ,  A61K47/34 ,  C12N15/113 ,  A61K31/713

CPC classification number: A61K9/5036 ,  A61K9/51 ,  A61K9/5161 ,  A61K9/5184 ,  A61K31/713 ,  A61K47/34 ,  A61K48/00 ,  C12N15/113 ,  C12N15/87 ,  C12N2310/14

Abstract: Delivery systems and their methods of formation are generally provided. The delivery system can protect a delivery molecule (e.g., DNA/RNA) and deliver it into a cell via serum. In one embodiment, the method can include binding a delivery molecule with polyethylenimine such that an end of the delivery molecule is exposed; capping the end of the delivery molecule with a first biocompatible polymer to form a core; and encapsulating the core with a second biocompatible polymer. The resulting delivery system can include a delivery molecule bonded with polyethylenimine such that an end of the delivery molecule is exposed; a first biocompatible polymer electrostatically bonded to the end of the delivery molecule to form a core; and a second biocompatible polymer encapsulating the core.

Abstract translation: 一般提供输送系统及其形成方法。 递送系统可以保护递送分子（例如DNA / RNA）并通过血清将其递送到细胞中。 在一个实施方案中，该方法可以包括将递送分子与聚乙烯亚胺结合，使得递送分子的末端被暴露; 用第一生物相容性聚合物覆盖递送分子的末端以形成核心; 并用第二生物相容性聚合物包封核心。 所得到的递送系统可以包括与聚乙烯亚胺结合的递送分子，使得分泌分子的末端被暴露; 第一生物相容性聚合物静电结合到输送分子的末端以形成核心; 和封装芯的第二生物相容性聚合物。