公开(公告)号：US20200016090A1

公开(公告)日：2020-01-16

申请号：US16578688

申请日：2019-09-23

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： EHSAN JABBARZADEH ,  SARA ESLAMBOLCHIMOGHADAM

IPC: A61K31/047 ,  A61P17/02

Abstract: Methods and compositions are described for use in encouraging angiogenesis and skin healing as may be utilized in wound treatment as well as in encouragement of angiogenesis in disease. Compositions include an effective amount of a natural pimarane diterpenoid extract of Hymenocrater elegans, or a derivative, analogue, or homolog thereof. Compounds based upon this natural extract have been found to be highly effective in vascular formation and skin closure while exhibiting low toxicity.

公开(公告)号：US20230365938A1

公开(公告)日：2023-11-16

申请号：US18357658

申请日：2023-07-24

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： EHSAN JABBARZADEH ,  MARIA YANEZ ,  SARA ESLAMBOLCHIMOGHADAM

IPC: C12N5/0775 ,  C12N5/00 ,  A61K35/28

CPC classification number: C12N5/0668 ,  C12N5/0018 ,  A61K35/28 ,  C12N2500/76 ,  C12N2500/38 ,  C12N2500/30

Abstract: Methods for culturing cells, compositions comprising the cell culture product, and applications for the compositions are described. Methods include culturing cells with a media that includes a catalyst compound, which can include a stilbene or a nicotinamide compound, so as to control the secretome of the cells. Compositions that include the cell culture product include the cell secretome or components thereof in conjunction with at least one catalyst compound. Products can be utilized as a cell culture media or can be utilized in therapeutic applications.

公开(公告)号：US20200072756A1

公开(公告)日：2020-03-05

申请号：US16545459

申请日：2019-08-20

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： EHSAN JABBARZADEH ,  SARA ESLAMBOLCHIMOGHADAM

IPC: G01N21/80 ,  A61B5/145

Abstract: Medical swabs incorporating a pH indicator in an absorbent crosslinked hydrogel matrix. The medical swabs can provide for visual monitoring of biological pH. The medical swabs can be used to monitor wounds, such as chronic wounds, burn wounds, surgical wounds, etc., as well as other biological fluids. The swabs can be used for early detection of chronic wounds and/or early detection of bacterial infections.

公开(公告)号：US20200069482A1

公开(公告)日：2020-03-05

申请号：US16560125

申请日：2019-09-04

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： EHSAN JABBARZADEH ,  SARA ESLAMBOLCHIMOGHADAM

IPC: A61F13/42 ,  A61B5/00 ,  A61F13/00 ,  B01J20/26 ,  B01J20/28 ,  B01J20/32

Abstract: Wound dressings, methods for forming the wound dressings, and methods for using the wound dressings are described. Wound dressings include a polymeric composition that includes a biocompatible polymer and a pH indicating agent. The polymeric composition can be at a wound contacting surface of a wound dressing in the form of, e.g., a fiber, a hydrogel, or a microsphere. The color of the polymeric composition as determined by the pH indicating agent can indicate the presence of infection or a chronic wound state. The wound dressings can be used for early detection of healing abnormalities in acute, chronic, or burn wounds.

公开(公告)号：US20230296528A1

公开(公告)日：2023-09-21

申请号：US18323552

申请日：2023-05-25

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： EHSAN JABBARZADEH ,  SARA ESLAMBOLCHIMOGHADAM

IPC: G01N21/80 ,  A61B5/145

CPC classification number: G01N21/80 ,  A61B5/14539 ,  A61B2562/12

Abstract: Medical swabs incorporating a pH indicator in an absorbent crosslinked hydrogel matrix. The medical swabs can provide for visual monitoring of biological pH. The medical swabs can be used to monitor wounds, such as chronic wounds, burn wounds, surgical wounds, etc., as well as other biological fluids. The swabs can be used for early detection of chronic wounds and/or early detection of bacterial infections.

公开(公告)号：US20200069478A1

公开(公告)日：2020-03-05

申请号：US16539192

申请日：2019-08-13

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： EHSAN JABBARZADEH ,  SARA ESLAMBOLCHIMOGHADAM

IPC: A61F13/02 ,  A61F13/00 ,  A61L27/52 ,  A61L15/42

Abstract: Wound dressings, methods for forming the wound dressings, and methods for using the wound dressings are described. Wound dressings include a crosslinked hydrogel matrix and a plurality of porous absorbent microspheres encapsulated in the crosslinked matrix. The hydrogel matrix and the microspheres can include the same or different hydrogel polymers, e.g., alginates or the like. The wound dressings can be used in treating chronic wounds and burn wounds and can promote autolytic debridement.