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公开(公告)号：US20200030254A1
公开(公告)日：2020-01-30
申请号：US16578673
申请日：2019-09-23
Applicant: UNIVERSITY OF SOUTH CAROLINA
Inventor： EHSAN JABBARZADEH , SARA Eslambolchimoghadam
IPC: A61K31/047 , A61P17/02
Abstract: Methods and compositions are described for use in encouraging angiogenesis and skin healing as may be utilized in wound treatment, as well as in encouragement of angiogenesis in disease. Compositions include an effective amount of a natural pimarane diterpenoid extract of Hymenocrater elegans, or a derivative, analogue, or homolog thereof. Compounds based upon this natural extract have been found to be highly effective in vascular formation and skin closure while exhibiting low toxicity.
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公开(公告)号：US20230365938A1
公开(公告)日：2023-11-16
申请号：US18357658
申请日：2023-07-24
Applicant: UNIVERSITY OF SOUTH CAROLINA
Inventor： EHSAN JABBARZADEH , MARIA YANEZ , SARA ESLAMBOLCHIMOGHADAM
IPC: C12N5/0775 , C12N5/00 , A61K35/28
CPC classification number: C12N5/0668 , C12N5/0018 , A61K35/28 , C12N2500/76 , C12N2500/38 , C12N2500/30
Abstract: Methods for culturing cells, compositions comprising the cell culture product, and applications for the compositions are described. Methods include culturing cells with a media that includes a catalyst compound, which can include a stilbene or a nicotinamide compound, so as to control the secretome of the cells. Compositions that include the cell culture product include the cell secretome or components thereof in conjunction with at least one catalyst compound. Products can be utilized as a cell culture media or can be utilized in therapeutic applications.
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公开(公告)号：US20200016090A1
公开(公告)日：2020-01-16
申请号：US16578688
申请日：2019-09-23
Applicant: UNIVERSITY OF SOUTH CAROLINA
Inventor： EHSAN JABBARZADEH , SARA ESLAMBOLCHIMOGHADAM
IPC: A61K31/047 , A61P17/02
Abstract: Methods and compositions are described for use in encouraging angiogenesis and skin healing as may be utilized in wound treatment as well as in encouragement of angiogenesis in disease. Compositions include an effective amount of a natural pimarane diterpenoid extract of Hymenocrater elegans, or a derivative, analogue, or homolog thereof. Compounds based upon this natural extract have been found to be highly effective in vascular formation and skin closure while exhibiting low toxicity.
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公开(公告)号：US20190070205A1
公开(公告)日：2019-03-07
申请号：US16122087
申请日：2018-09-05
Applicant: UNIVERSITY OF SOUTH CAROLINA
Inventor： EHSAN JABBARZADEH , SARA ESLAMBOLCHI MOGHADAM
IPC: A61K31/7048 , A61K36/185 , A61P17/02
Abstract: Methods and compositions are described for use in encouraging angiogenesis and skin healing as may be utilized in wound treatment as well as in encouragement of angiogenesis in disease. Compositions include an effective amount of at least one of a flavonoid and a chlorogenic acid that are natural extracts of Parrotia persica, or their derivatives, analogues, or homologs. Compounds based upon these natural extracts have been found to be highly effective in vascular formation and skin closure while exhibiting low toxicity.
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Patent Agency Ranking
公开(公告)号：US20230296528A1
公开(公告)日：2023-09-21
申请号：US18323552
申请日：2023-05-25
Applicant: UNIVERSITY OF SOUTH CAROLINA
Inventor： EHSAN JABBARZADEH , SARA ESLAMBOLCHIMOGHADAM
CPC classification number: G01N21/80 , A61B5/14539 , A61B2562/12
Abstract: Medical swabs incorporating a pH indicator in an absorbent crosslinked hydrogel matrix. The medical swabs can provide for visual monitoring of biological pH. The medical swabs can be used to monitor wounds, such as chronic wounds, burn wounds, surgical wounds, etc., as well as other biological fluids. The swabs can be used for early detection of chronic wounds and/or early detection of bacterial infections.
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公开(公告)号：US20200069478A1
公开(公告)日：2020-03-05
申请号：US16539192
申请日：2019-08-13
Applicant: UNIVERSITY OF SOUTH CAROLINA
Inventor： EHSAN JABBARZADEH , SARA ESLAMBOLCHIMOGHADAM
Abstract: Wound dressings, methods for forming the wound dressings, and methods for using the wound dressings are described. Wound dressings include a crosslinked hydrogel matrix and a plurality of porous absorbent microspheres encapsulated in the crosslinked matrix. The hydrogel matrix and the microspheres can include the same or different hydrogel polymers, e.g., alginates or the like. The wound dressings can be used in treating chronic wounds and burn wounds and can promote autolytic debridement.
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公开(公告)号：US20200368180A1
公开(公告)日：2020-11-26
申请号：US16985476
申请日：2020-08-05
Applicant: UNIVERSITY OF SOUTH CAROLINA
Inventor： EHSAN JABBARZADEH , WESLEY F. TAYLOR , SARA ESLAMBOLCHI MOGHADAM
IPC: A61K31/122 , A61P35/02
Abstract: A deacetylnemorone abietane diterpenoid is utilized in the prevention of growth and development of pathogenic cells, e.g., cancer cells. The deacetylnemorone can have the following structure: or a tautomer there of in which R1, R2, and R3 are independently selected from —H, C1-10 alkyl, C1-10 alkoxy, C1-10 alkenyl, C1-10 alkenoxy, —OH, —OAc, —CHO, -Ph, —OC6H5, —OC6H4OH, —COC6H5, —OCONH2, —OCONHCH3, —OCOC6H4NH2, —NH2, or ═O. The deacetylnemorone shows efficacy in treatment and prevention of a wide range of cancer types, as well as other neoplastic diseases as a chemo-preventative, a primary or secondary cytotoxic agent, a sensitizer for other therapies, or one component of a combinatorial treatment.
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公开(公告)号：US20200072756A1
公开(公告)日：2020-03-05
申请号：US16545459
申请日：2019-08-20
Applicant: UNIVERSITY OF SOUTH CAROLINA
Inventor： EHSAN JABBARZADEH , SARA ESLAMBOLCHIMOGHADAM
Abstract: Medical swabs incorporating a pH indicator in an absorbent crosslinked hydrogel matrix. The medical swabs can provide for visual monitoring of biological pH. The medical swabs can be used to monitor wounds, such as chronic wounds, burn wounds, surgical wounds, etc., as well as other biological fluids. The swabs can be used for early detection of chronic wounds and/or early detection of bacterial infections.
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公开(公告)号：US20200069482A1
公开(公告)日：2020-03-05
申请号：US16560125
申请日：2019-09-04
Applicant: UNIVERSITY OF SOUTH CAROLINA
Inventor： EHSAN JABBARZADEH , SARA ESLAMBOLCHIMOGHADAM
Abstract: Wound dressings, methods for forming the wound dressings, and methods for using the wound dressings are described. Wound dressings include a polymeric composition that includes a biocompatible polymer and a pH indicating agent. The polymeric composition can be at a wound contacting surface of a wound dressing in the form of, e.g., a fiber, a hydrogel, or a microsphere. The color of the polymeric composition as determined by the pH indicating agent can indicate the presence of infection or a chronic wound state. The wound dressings can be used for early detection of healing abnormalities in acute, chronic, or burn wounds.
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