公开(公告)号：US20200030254A1

公开(公告)日：2020-01-30

申请号：US16578673

申请日：2019-09-23

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： EHSAN JABBARZADEH ,  SARA Eslambolchimoghadam

IPC: A61K31/047 ,  A61P17/02

Abstract: Methods and compositions are described for use in encouraging angiogenesis and skin healing as may be utilized in wound treatment, as well as in encouragement of angiogenesis in disease. Compositions include an effective amount of a natural pimarane diterpenoid extract of Hymenocrater elegans, or a derivative, analogue, or homolog thereof. Compounds based upon this natural extract have been found to be highly effective in vascular formation and skin closure while exhibiting low toxicity.