公开(公告)号：US11866474B2

公开(公告)日：2024-01-09

申请号：US18069797

申请日：2022-12-21

Applicant: UNIVERSITY OF SOUTH FLORIDA

Inventor： Jianfeng Cai ,  Sami Abdulkadir

IPC: C07K14/475 ,  A61P9/00 ,  A61K38/00

CPC classification number: C07K14/475 ,  A61P9/00 ,  A61K38/00

Abstract: Provided herein are novel VEGF mimics, pharmaceutical compositions thereof, and methods of their use in increasing or reducing angiogenesis.

公开(公告)号：US11718585B2

公开(公告)日：2023-08-08

申请号：US17516546

申请日：2021-11-01

Applicant: University of South Florida

Inventor： Jianfeng Cai ,  Peng Teng ,  Alekhya Nimmagadda

IPC: C07D233/46 ,  A61K45/06 ,  A61P31/04 ,  A61K31/4178 ,  C07D403/12 ,  A61K38/12

CPC classification number: C07D233/46 ,  A61K31/4178 ,  A61K45/06 ,  A61P31/04 ,  C07D403/12 ,  A61K38/12

Abstract: Provided are novel bis-cyclic guanidine compounds, and the use thereof for treating bacterial infection.

公开(公告)号：US20220195524A1

公开(公告)日：2022-06-23

申请号：US17568617

申请日：2022-01-04

Applicant: UNIVERSITY OF SOUTH FLORIDA ,  THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS

Inventor： Niketa A. Patel ,  Jianfeng Cai

IPC: C12Q1/6883 ,  A61K31/404

Abstract: Described herein are assays, methods, and devices for diagnosing/prognosing Alzheimer's disease (AD) and/or a neurodegenerative disease in a subject. The assays, methods, and/or devices described herein can be configured to detect GAS5 long-coding RNAs and/or expression thereof in a sample from a subject.

公开(公告)号：US11278521B2

公开(公告)日：2022-03-22

申请号：US16063077

申请日：2016-12-15

Applicant: UNIVERSITY OF SOUTH FLORIDA ,  The United States Government as Represented by The Department of Veterans Affairs

Inventor： Niketa A. Patel ,  Jianfeng Cai

IPC: A61K31/396 ,  A61K31/395 ,  A61K45/06 ,  C07D285/00

Abstract: Provided herein are compounds that can bind GAS5 long non-coding RNA, compositions thereof, and uses thereof.

公开(公告)号：US11149065B2

公开(公告)日：2021-10-19

申请号：US16916517

申请日：2020-06-30

Applicant: University of South Florida

Inventor： Jianfeng Cai ,  Yan Shi

IPC: C07K7/54 ,  A61K38/12 ,  A61P35/00 ,  C40B40/10 ,  C40B50/16 ,  C07K1/04 ,  A61K38/00 ,  C07K7/06 ,  C07K17/14 ,  G01N33/566 ,  C40B30/04

Abstract: A one-bead-two-compound combinatorial synthesis technique provides libraries of macrocyclic peptidomimetic compounds and compositions with use as ligands for the Ephrin type-A receptor 2 (EphA2). The one-bead-two-compound technique and libraries of macrocyclic compounds are useful as research tools in drug discovery and/or to treat or prevent a range of diseases or disorders.

公开(公告)号：US20210198221A1

公开(公告)日：2021-07-01

申请号：US16063077

申请日：2016-12-15

Applicant: University of South Florida ,  The United States Government as Represented by the Department of Veterans Affairs Office of General

Inventor： Niketa A. Patel ,  Jianfeng Cai

IPC: C07D285/00 ,  A61K45/06

Abstract: Provided herein are compounds that can bind GAS5 long non-coding RNA, compositions thereof, and uses thereof.

公开(公告)号：US20200231572A1

公开(公告)日：2020-07-23

申请号：US16629805

申请日：2018-06-21

Applicant: University of South Florida

Inventor： Jianfeng Cai ,  Peng Teng ,  Alekhya Nimmagadda

IPC: C07D403/12 ,  A61P31/04 ,  C07D233/46

Abstract: Provided are novel bis-cyclic guanidine compounds, and the use thereof for treating bacterial infection.

公开(公告)号：US10507228B2

公开(公告)日：2019-12-17

申请号：US15567655

申请日：2016-04-20

Applicant: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. ,  UNIVERSITY OF SOUTH FLORIDA

Inventor： Said M. Sebti ,  Jianfeng Cai

IPC: A61K38/12 ,  A61K38/10 ,  A61K38/00 ,  C07K7/56 ,  C07K7/08 ,  C07K7/50 ,  C07K14/82 ,  C07K14/47

Abstract: Stapled peptides and methods of using them to inhibit the Kras/Raf interaction are disclosed herein.

公开(公告)号：US10022420B2

公开(公告)日：2018-07-17

申请号：US15438932

申请日：2017-02-22

Applicant: UNIVERSITY OF SOUTH FLORIDA

Inventor： Jianfeng Cai ,  Chuanhai Cao ,  Haifan Wu ,  Yaqiong Li ,  Ge Bai

IPC: A61K38/07

Abstract: Embodiments of the present disclosure provide for γ-AApeptides, γ-AApeptide building blocks, methods of making γ-AApeptides and libraries of γ-AApeptides, methods of screening the γ-AApeptide libraries for desired peptidomimetic activity, and the like. The present disclosure also provides for γ-AApeptides that are inhibitors of Aβ peptide aggregation, methods of inhibiting and disassembling Aβ peptide aggregation, methods of inhibiting the toxicity of Aβ aggregates towards N2a neuroblasotma cells, as well as methods and compounds for treating Alzheimer's disease.

公开(公告)号：US12162874B2

公开(公告)日：2024-12-10

申请号：US17705208

申请日：2022-03-25

Applicant: University of South Florida

Inventor： Jianfeng Cai ,  Mengmeng Zheng

IPC: C07D417/06 ,  A61K47/54 ,  B01L3/00 ,  B01L9/00 ,  C07D311/44 ,  C07D317/46 ,  C07K16/28 ,  C07K16/30

Abstract: Disclosed are cyclic γ-amino acid peptide compounds, methods of using said compounds, and kits comprising said compounds. More specifically, disclosed are human epidermal growth factor receptor 2 (HER2) specific cyclic γ-amino acid peptide compounds, methods of using said compounds in the treatment of cell proliferative diseases or disorders, methods of detecting HER2 using the compounds, and kits comprising the compounds.