公开(公告)号：US12286445B2

公开(公告)日：2025-04-29

申请号：US17960092

申请日：2022-10-04

Applicant: UNIVERSITY OF SOUTH FLORIDA

Inventor： Michael John Zaworotko ,  Naga Duggirala ,  Adam John Smith ,  Roland Douglas Shytle

IPC: C07F1/02 ,  A61K33/00 ,  A61K33/14 ,  A61K45/06 ,  C07C229/08 ,  C07D207/16

Abstract: A cocrystal having the formula LiX·aM, or a solvate or hydrate thereof, wherein X is a conjugate base of an organic acid, M is a neutral organic molecule, and a is from 0.5 to 4, pharmaceutical compositions comprising such cocrystals, cocrystal solvates, or cocrystal hydrates, and methods of preparing such cocrystals, cocrystal solvates, or cocrystal hydrates, and such pharmaceutical compositions.

公开(公告)号：US10435416B2

公开(公告)日：2019-10-08

申请号：US15793435

申请日：2017-10-25

Applicant: University of South Florida

Inventor： Michael John Zaworotko ,  Naga Duggirala ,  Adam John Smith ,  Roland Douglas Shytle

IPC: C07F1/02 ,  A61K33/00 ,  A61K33/14 ,  A61K45/06 ,  C07C229/08 ,  C07D207/16

Abstract: A cocrystal having the formula LiX.aM, or a solvate or hydrate thereof, wherein X is a conjugate base of an organic acid, M is a neutral organic molecule, and a is from 0.5 to 4, pharmaceutical compositions comprising such cocrystals, cocrystal solvates, or cocrystal hydrates, and methods of preparing such cocrystals, cocrystal solvates, or cocrystal hydrates, and such pharmaceutical compositions.

公开(公告)号：US09840521B2

公开(公告)日：2017-12-12

申请号：US14779774

申请日：2014-04-18

Applicant: University of South Florida

Inventor： Michael John Zaworotko ,  Naga Duggirala ,  Adam John Smith ,  Roland Douglas Shytle

IPC: A61K33/00 ,  A61K33/14 ,  A61K45/06 ,  C07C229/08 ,  C07D207/16 ,  C07F1/02

CPC classification number: C07F1/02 ,  A61K33/00 ,  A61K33/14 ,  A61K45/06 ,  C07C229/08 ,  C07D207/16

Abstract: A cocrystal having the formula LiX.aM, or a solvate or hydrate thereof, wherein X is a conjugate base of an organic acid, M is a neutral organic molecule, and a is from 0.5 to 4, pharmaceutical compositions comprising such cocrystals, cocrystal solvates, or cocrystal hydrates, and methods of preparing such cocrystals, cocrystal solvates, or cocrystal hydrates, and such pharmaceutical compositions.

公开(公告)号：US11459341B1

公开(公告)日：2022-10-04

申请号：US17119270

申请日：2020-12-11

Applicant: UNIVERSITY OF SOUTH FLORIDA

Inventor： Michael John Zaworotko ,  Naga Duggirala ,  Adam John Smith ,  Roland Douglas Shytle

IPC: C07F1/02 ,  A61K33/00 ,  C07C229/00 ,  A61K45/06 ,  C07D207/16 ,  A61K33/14 ,  C07C229/08

Abstract: A cocrystal having the formula LiX.aM, or a solvate or hydrate thereof, wherein X is a conjugate base of an organic acid, M is a neutral organic molecule, and a is from 0.5 to 4, pharmaceutical compositions comprising such cocrystals, cocrystal solvates, or cocrystal hydrates, and methods of preparing such cocrystals, cocrystal solvates, or cocrystal hydrates, and such pharmaceutical compositions.