公开(公告)号：US20230217977A1

公开(公告)日：2023-07-13

申请号：US18184618

申请日：2023-03-15

Applicant: UNIVERSITY OF SOUTH FLORIDA

Inventor： Rex M. Philpot ,  Bethany Johns

IPC: A61K31/14 ,  A61K31/704 ,  A61K31/675 ,  A61P35/00 ,  A23L33/00

CPC classification number: A61K31/14 ,  A61K31/704 ,  A61K31/675 ,  A61P35/00 ,  A23L33/30 ,  A23L33/40

Abstract: Described herein is a method for reducing tumor volume in a subject, the method including the steps of administering a cancer treatment (administration of at least one chemotherapeutic agent and/or application of radiation) to the subject in conjunction with the administration of choline, a choline metabolite, a choline precursor molecule, or a combination thereof. In another aspect, the disclosure relates to a method for enhancing cognitive response in a subject during cancer treatment, the method including the steps of administering cancer treatment (administration of at least one chemotherapeutic agent and/or application of radiation) to the subject in conjunction with the administration of choline, a choline metabolite, a choline precursor molecule, or a combination thereof. In still another aspect, choline, a choline metabolite, a choline precursor molecule, or a combination thereof can be administered in the form of a choline-enriched diet, a choline supplement, or a combination thereof. In some aspects, the method also enhances the effectiveness of chemotherapy.