公开(公告)号：US10772843B2

公开(公告)日：2020-09-15

申请号：US15994079

申请日：2018-05-31

Applicant: UNIVERSITY OF SOUTH FLORIDA

Inventor： Kathleen Emily-Ann Halasz ,  Yashwant V. Pathak ,  Vijaykumar Bhadabhai Sutariya

IPC: A61K9/51 ,  A61P27/02 ,  A61K9/00 ,  A61K31/573 ,  A61K31/7048 ,  B82Y5/00

Abstract: The present invention concerns nanoparticles useful for treating posterior segment ocular diseases or conditions, such as macular degeneration and diabetic retinopathy; compositions comprising the nanoparticles; methods for producing the nanoparticles; and methods for treating posterior segment ocular diseases or conditions, comprising administering the nanoparticles or compositions to the ocular posterior segment of an afflicted eye.

公开(公告)号：US11207274B2

公开(公告)日：2021-12-28

申请号：US17020699

申请日：2020-09-14

Applicant: UNIVERSITY OF SOUTH FLORIDA

Inventor： Kathleen Emily-Ann Halasz ,  Yashwant V. Pathak ,  Vijaykumar Bhadabhai Sutariya

IPC: A61K9/51 ,  A61K31/573 ,  A61K9/00 ,  A61P27/02 ,  A61K31/7048 ,  B82Y5/00

Abstract: The present invention concerns nanoparticles useful for treating posterior segment ocular diseases or conditions, such as macular degeneration and diabetic retinopathy; compositions comprising the nanoparticles; methods for producing the nanoparticles; and methods for treating posterior segment ocular diseases or conditions, comprising administering the nanoparticles or compositions to the ocular posterior segment of an afflicted eye.

公开(公告)号：US11730703B2

公开(公告)日：2023-08-22

申请号：US17562372

申请日：2021-12-27

Applicant: UNIVERSITY OF SOUTH FLORIDA

Inventor： Kathleen Emily-Ann Halasz ,  Yashwant V. Pathak ,  Vijaykumar Bhadabhai Sutariya

IPC: A61K9/51 ,  A61K9/00 ,  A61K31/573 ,  A61K31/7048 ,  B82Y5/00 ,  A61P27/02

CPC classification number: A61K9/5153 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/5192 ,  A61K31/573 ,  A61P27/02 ,  A61K31/7048 ,  A61K2300/00 ,  B82Y5/00

Abstract: The present invention concerns nanoparticles useful for treating posterior segment ocular diseases or conditions, such as macular degeneration and diabetic retinopathy; compositions comprising the nanoparticles; methods for producing the nanoparticles; and methods for treating posterior segment ocular diseases or conditions, comprising administering the nanoparticles or compositions to the ocular posterior segment of an afflicted eye.

公开(公告)号：US10973776B1

公开(公告)日：2021-04-13

申请号：US16892423

申请日：2020-06-04

Applicant: University of South Florida

Inventor： Vijaykumar Bhadabhai Sutariya ,  Anjali A. Hirani ,  Yashwant V. Pathak

IPC: A61K9/70 ,  A61K31/58 ,  A61K31/56

Abstract: The present invention provides a sustained drug delivery system for the treatment of age-related macular degeneration (AMD), comprising corticosteroid encapsulated nanoparticles incorporated into a thermoreversible hydrogel. The corticosteroid may be triamcinolone acetate (TA), dexamethasone, or loteprednol etabonate (LE). The proposed drug delivery system is nontoxic to ARPE-19 (retinal pigment epithelium) cells and significantly reduces VEGF (vascular endothelial growth factor) expression as compared to solutions of the coticosteroids. The present invention provides sustained delivery of the corticosteroid to the posterior segment of the eye, reducing the frequency of intraocular injections necessary to maintain therapeutic concentrations.