公开(公告)号：US20220283185A1

公开(公告)日：2022-09-08

申请号：US17637700

申请日：2020-08-27

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA

Inventor： Melanie D. Sweeney ,  Abhay P. Sagare ,  Berislav V. Zlokovic

IPC: G01N33/68 ,  G01N21/66 ,  G01N33/577 ,  G01N21/76

Abstract: A highly sensitive immunoassay has been developed and validated. In various embodiments, the assay comprises an immunoassay usable to measure soluble PDGFRβ (sPDGFR-β) in a human biofluid sample such as cerebrospinal fluid (CSF). In various embodiments, elevated sPDGFR-β in a human biofluid sample reflects pericyte and blood-brain barrier (BBB) injury, and is therefore an early biomarker of human cognitive dysfunction, dementia, and/or Alzheimer's disease.