公开(公告)号：US20250092143A1

公开(公告)日：2025-03-20

申请号：US18580889

申请日：2022-07-22

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA

Inventor： Yong ZHANG ,  Qinqin CHENG

IPC: C07K16/28 ,  A61K9/50 ,  A61K35/00 ,  A61K38/00 ,  C07K14/705 ,  C07K14/71

Abstract: The disclosure provides for an engineered extracelluar vesicle and methods of using the same where the engineered extracellular vesicle comprises a first fusion protein having the formula A-B-C, wherein A is a first antibody moiety, B is a second antibody moiety, and C is a first exosomal protein transmembrane domain; and a second fusion protein comprising the formula D-E-F, wherein D is a first protein binding moiety, E is a second exosomal membrane protein transmembrane domain, and F is a second protein binding moiety; wherein both the first fusion protein and the second fusion protein are displayed on a surface of the engineered extracellular vesicle, and the first antibody moiety and the second antibody moiety separately bind to a an immune cell marker protein and a cancer cell surface-marker protein, and the first binding protein moiety and the second protein binding moiety separately bind to a second immune cell marker protein and a second cancer cell surface-marker protein.