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公开(公告)号：US11484625B2
公开(公告)日：2022-11-01
申请号：US16762398
申请日：2018-11-08
Applicant: Alfred E. Mann Institute for Biomedical Engineering at the University of Southern California
Inventor： Yang Chai , Yong Chen , Yuan Yuan , Yuxing Guo , Xiangjia Li , Zoe Johnson
Abstract: This invention relates to a bone regeneration product comprising at least one stem cell, at least one scaffold, and at least one stem cell. The stem cells suitable for this invention may comprise stem cells suitable for a dense bone regeneration, stem cells suitable for a spongy bone regeneration, or a combination thereof. The bone regeneration product may further comprise a growth factor. This invention also relates to a bone regeneration method and treatment of any bone that has a critical size defect. This invention also relates to a scaffold. This invention further relates to a 3D printed scaffold comprising hydroxyapatite (HA) and tricalcium phosphate (TCP). This invention also relates to a scaffold comprising a polymer. The polymer of this invention may be prepared by using photocurable polymers and/or monomers. The scaffold of this invention may comprise a growth factor and a small molecule. The small molecule N may be a Smurf1 inhibitor.
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公开(公告)号：US20220118704A1
公开(公告)日：2022-04-21
申请号：US17565778
申请日：2021-12-30
Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
Inventor： Yong Chen , Xiangjia Li
IPC: B29C64/277 , B29C64/135 , B33Y50/02 , B33Y10/00 , B33Y30/00 , B29C64/393
Abstract: Methods, systems, and devices including a light guide tool for multi-axis additive manufacturing. The light guide tool includes a tubular light guide. The tubular light guide may be made from an optically transmissive material enclosed by one or more reflective side walls that are interposed between opposing optically transmissive ends. The light guide tool includes an optical coupling fixed to a first end of the optically transmissive ends of the tubular light guide. The optical coupling is configured to couple to a lens. The light guide tool includes a transparent non-stick coating. The transparent non-stick coating is adhered over a second end of the optically transmissive ends of the tubular light guide. The light guide tool includes a lens. The lens is coupled to the optical coupling and configured to emit a two-dimensional light pattern.
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公开(公告)号：US20240157024A1
公开(公告)日：2024-05-16
申请号：US17755462
申请日：2020-10-30
Applicant: University of Southern California
Inventor： Xiangjia Li , Yong Chen , Yang Chai
CPC classification number: A61L27/12 , A61L27/222 , A61L27/34 , A61L2430/02
Abstract: This disclosure generally relates to a ceramic scaffold. This disclosure particularly relates to a ceramic scaffold useful for bone regenerations. This disclosure also relates to a ceramic scaffold comprising hydroxyapatite (HA), tricalcium phosphate (TCP), or a mixture thereof. This disclosure also relates to a ceramic scaffold with high mechanical strength and flexibility. This disclosure further relates to a ceramic scaffold manufactured through a three-dimensional (3D) printing process, methods of manufacturing a ceramic scaffold and methods of replacing bone in a subject using the ceramic scaffold.
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Patent Agency Ranking
公开(公告)号：US11981079B2
公开(公告)日：2024-05-14
申请号：US17565778
申请日：2021-12-30
Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
Inventor： Yong Chen , Xiangjia Li
IPC: B29C64/277 , B29C64/135 , B29C64/393 , B33Y10/00 , B33Y30/00 , B33Y50/02
CPC classification number: B29C64/277 , B29C64/135 , B29C64/393 , B33Y10/00 , B33Y30/00 , B33Y50/02
Abstract: Methods, systems, and devices including a light guide tool for multi-axis additive manufacturing. The light guide tool includes a tubular light guide. The tubular light guide may be made from an optically transmissive material enclosed by one or more reflective side walls that are interposed between opposing optically transmissive ends. The light guide tool includes an optical coupling fixed to a first end of the optically transmissive ends of the tubular light guide. The optical coupling is configured to couple to a lens. The light guide tool includes a transparent non-stick coating. The transparent non-stick coating is adhered over a second end of the optically transmissive ends of the tubular light guide. The light guide tool includes a lens. The lens is coupled to the optical coupling and configured to emit a two-dimensional light pattern.
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公开(公告)号：US11214005B2
公开(公告)日：2022-01-04
申请号：US15868891
申请日：2018-01-11
Applicant: University of Southern California
Inventor： Yong Chen , Xiangjia Li
IPC: B29C64/277 , B29C64/135 , B33Y50/02 , B33Y10/00 , B33Y30/00 , B29C64/393
Abstract: Methods, systems, and devices including a light guide tool for multi-axis additive manufacturing. The light guide tool includes a tubular light guide. The tubular light guide may be made from an optically transmissive material enclosed by one or more reflective side walls that are interposed between opposing optically transmissive ends. The light guide tool includes an optical coupling fixed to a first end of the optically transmissive ends of the tubular light guide. The optical coupling is configured to couple to a lens. The light guide tool includes a transparent non-stick coating. The transparent non-stick coating is adhered over a second end of the optically transmissive ends of the tubular light guide. The light guide tool includes a lens. The lens is coupled to the optical coupling and configured to emit a two-dimensional light pattern.
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公开(公告)号：US10308007B2
公开(公告)日：2019-06-04
申请号：US15187713
申请日：2016-06-20
Applicant: University of Southern California
Inventor： Yong Chen , Huachao Mao , Xiangjia Li
IPC: B29C64/124 , B33Y50/02 , B33Y30/00 , B29C64/135 , B29C64/20 , B29C64/386 , B29C64/277 , B29C64/129 , B29C64/255 , B29C64/286 , B29C64/241
Abstract: Methods, systems, and apparatus including medium-encoded computer program products for performing additive manufacturing (AM) using continuous resin flow based mask video projection stereolithography (MVP-SL) According to an aspect, a system for additive manufacturing of an object in three dimensions consisting of an X dimension, a Y dimension, and a Z dimension, the system comprising: a tank configured to contain a liquid resin; a first translation stage coupled with the tank, the first translation stage being configured to move the tank in the X dimension, the Y dimension, or both; a second translation stage coupled with a build platform, the second translation stage being configured to move the build platform in the Z dimension; and a computer control system to cause the second translation stage to elevate the build platform in the Z dimension simultaneously with causing the first translation stage to perform the sliding motion.
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公开(公告)号：US20180194064A1
公开(公告)日：2018-07-12
申请号：US15868891
申请日：2018-01-11
Applicant: University of Southern California
Inventor： Yong Chen , Xiangjia Li
IPC: B29C64/277 , B29C64/135 , B29C64/393 , B33Y10/00 , B33Y30/00 , B33Y50/02
CPC classification number: B29C64/277 , B29C64/135 , B29C64/393 , B33Y10/00 , B33Y30/00 , B33Y50/02
Abstract: Methods, systems, and devices including a light guide tool for multi-axis additive manufacturing. The light guide tool includes a tubular light guide. The tubular light guide may be made from an optically transmissive material enclosed by one or more reflective side walls that are interposed between opposing optically transmissive ends. The light guide tool includes an optical coupling fixed to a first end of the optically transmissive ends of the tubular light guide. The optical coupling is configured to couple to a lens. The light guide tool includes a transparent non-stick coating. The transparent non-stick coating is adhered over a second end of the optically transmissive ends of the tubular light guide. The light guide tool includes a lens. The lens is coupled to the optical coupling and configured to emit a two-dimensional light pattern.
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8.发明申请公开(公告)号：US20160368210A1
公开(公告)日：2016-12-22
申请号：US15187713
申请日：2016-06-20
Applicant: University of Southern California
Inventor： Yong Chen , Huachao Mao , Xiangjia Li
CPC classification number: B33Y50/02 , B29C64/135 , B29C64/20 , B29C64/386 , B33Y30/00
Abstract: Methods, systems, and apparatus including medium-encoded computer program products for performing additive manufacturing (AM) using continuous resin flow based mask video projection stereolithography (MVP-SL) According to an aspect, a system for additive manufacturing of an object in three dimensions consisting of an X dimension, a Y dimension, and a Z dimension, the system comprising: a tank configured to contain a liquid resin; a first translation stage coupled with the tank, the first translation stage being configured to move the tank in the X dimension, the Y dimension, or both; a second translation stage coupled with a build platform, the second translation stage being configured to move the build platform in the Z dimension; and a computer control system to cause the second translation stage to elevate the build platform in the Z dimension simultaneously with causing the first translation stage to perform the sliding motion.
Abstract translation: 包括用于使用基于连续树脂流动的掩模视频投影立体光刻（MVP-SL）进行添加剂制造（AM）的中等编码计算机程序产品的方法，系统和装置根据一个方面，一种用于三维的对象的附加制造系统 由X尺寸，Y尺寸和Z尺寸组成，所述系统包括：配置成容纳液体树脂的罐; 与所述罐结合的第一平移台，所述第一平移台被构造成在所述X尺寸，Y尺寸或两者中移动所述罐; 与构建平台耦合的第二平移台，所述第二平移台被构造成在所述Z维度中移动所述构建平台; 以及计算机控制系统，用于使所述第二平移台在所述Z维度中同时升高所述构建平台，同时使所述第一平移阶段执行所述滑动运动。
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