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Patent Agency Ranking
1.发明申请公开(公告)号：US20200316258A1
公开(公告)日：2020-10-08
申请号：US16899363
申请日：2020-06-11
Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
Inventor： Jay R. Lieberman , William Pannell , Yong Chen , Xuan Song , Sofia Bougioukli
IPC: A61L27/38 , A61L27/22 , A61L27/10 , A61L27/12 , A61L27/54 , B33Y80/00 , B33Y40/20 , B28B1/00 , B33Y70/00 , B29C64/379
Abstract: Disclosed herein are methods of regional gene-therapy with growth-factor transduced cells, in bone graft scenarios. In embodiments, the methods comprise use of 3D printed scaffolds.
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2.发明申请公开(公告)号：US20200022816A1
公开(公告)日：2020-01-23
申请号：US16337893
申请日：2017-09-29
Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
Inventor： Jay R. Lieberman , William Pannell , Yong Chen , Xuan Song , Sofia Bougioukli
Abstract: A method for repairing a bone defect of a patient includes providing a ceramic scaffold configured for filling the bone defect, loading the scaffold with growth factor transduced cells incorporating a gene that encodes a growth factor essential for bone formation, placing the ceramic scaffold with the growth factor transduced cells in or across the bone defect, and stabilizing the ceramic scaffold with the growth factor transduced cells in the patient until the bone defect is healed. An assembly for repairing a bone defect includes a ceramic scaffold configured for spanning the bone defect and a culture of live growth factor transduced cells incorporating a gene that encodes a growth factor essential for bone formation loaded onto the ceramic scaffold.
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公开(公告)号：US12016779B2
公开(公告)日：2024-06-25
申请号：US16337893
申请日：2017-09-29
Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
Inventor： Jay R. Lieberman , William Pannell , Yong Chen , Xuan Song , Sofia Bougioukli
CPC classification number: A61F2/30942 , A61F2/28 , A61K38/1875 , A61L27/10 , A61L27/3834 , A61L27/54 , A61F2002/30235 , A61F2002/30677 , A61F2002/30784 , A61F2310/00293 , A61L2300/414 , A61L2430/02 , B33Y10/00 , B33Y80/00
Abstract: A method for repairing a bone defect of a patient includes providing a ceramic scaffold configured for filling the bone defect, loading the scaffold with growth factor transduced cells incorporating a gene that encodes a growth factor essential for bone formation, placing the ceramic scaffold with the growth factor transduced cells in or across the bone defect, and stabilizing the ceramic scaffold with the growth factor transduced cells in the patient until the bone defect is healed. An assembly for repairing a bone defect includes a ceramic scaffold configured for spanning the bone defect and a culture of live growth factor transduced cells incorporating a gene that encodes a growth factor essential for bone formation loaded onto the ceramic scaffold.
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公开(公告)号：US12133933B2
公开(公告)日：2024-11-05
申请号：US16899363
申请日：2020-06-11
Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
Inventor： Jay R. Lieberman , William Pannell , Yong Chen , Xuan Song , Sofia Bougioukli
IPC: A61L27/38 , A61L27/10 , A61L27/12 , A61L27/22 , A61L27/54 , B28B1/00 , B29C64/379 , B29K509/02 , B29L31/00 , B33Y10/00 , B33Y40/20 , B33Y70/00 , B33Y80/00 , B29C64/129
Abstract: Disclosed herein are methods of regional gene-therapy with growth-factor transduced cells, in bone graft scenarios. In embodiments, the methods comprise use of 3D printed scaffolds.
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5.发明公开公开(公告)号：US20240325157A1
公开(公告)日：2024-10-03
申请号：US18742182
申请日：2024-06-13
Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
Inventor： Jay R. Lieberman , William Pannell , Yong Chen , Xuan Song , Sofia Bougioukli
CPC classification number: A61F2/30942 , A61F2/28 , A61K38/1875 , A61L27/10 , A61L27/3834 , A61L27/54 , A61F2002/30235 , A61F2002/30677 , A61F2002/30784 , A61F2310/00293 , A61L2300/414 , A61L2430/02 , B33Y10/00 , B33Y80/00
Abstract: A method for repairing a bone defect of a patient includes providing a ceramic scaffold configured for filling the bone defect, loading the scaffold with growth factor transduced cells incorporating a gene that encodes a growth factor essential for bone formation, placing the ceramic scaffold with the growth factor transduced cells in or across the bone defect, and stabilizing the ceramic scaffold with the growth factor transduced cells in the patient until the bone defect is healed. An assembly for repairing a bone defect includes a ceramic scaffold configured for spanning the bone defect and a culture of live growth factor transduced cells incorporating a gene that encodes a growth factor essential for bone formation loaded onto the ceramic scaffold.
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