公开(公告)号：US20190231891A1

公开(公告)日：2019-08-01

申请号：US16378922

申请日：2019-04-09

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： Young-Wook WON ,  David A. BULL ,  Amit N. PATEL

IPC: A61K47/60 ,  A61K49/00 ,  A61K35/28 ,  C12N5/00 ,  C12N5/0775 ,  A61K47/69 ,  A61K47/64 ,  A61K35/12

CPC classification number: A61K47/6425 ,  A61K35/28 ,  A61K47/60 ,  A61K47/64 ,  A61K47/6911 ,  A61K49/0041 ,  A61K49/0047 ,  A61K49/0084 ,  A61K2035/124 ,  C12N5/0006 ,  C12N5/0662 ,  C12N5/0663

Abstract: Described herein are compounds, compositions and methods for modification of the surface of a living cell with a therapeutically relevant targeting moiety. Also described herein are methods for treating disease states, such as acute myocardial ischemia or infarction, with said compositions, in a subject.

公开(公告)号：US20210077631A1

公开(公告)日：2021-03-18

申请号：US17107107

申请日：2020-11-30

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： Young-Wook WON ,  David A. BULL ,  Amit N. PATEL

IPC: A61K47/60 ,  C12N5/00 ,  C12N5/0775 ,  A61K49/00 ,  A61K47/64 ,  A61K47/69 ,  A61K35/28

Abstract: Described herein are compounds, compositions and methods for modification of the surface of a living cell with a therapeutically relevant targeting moiety. Also described herein are methods for treating disease states, such as acute myocardial ischemia or infarction, with said compositions, in a subject.

公开(公告)号：US20170000894A1

公开(公告)日：2017-01-05

申请号：US15113009

申请日：2015-01-20

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： Young-Wook WON ,  David A. BULL ,  Amit N. PATEL

IPC: A61K47/48 ,  C12N5/0775 ,  C12N5/00 ,  A61K35/28

CPC classification number: A61K47/48276 ,  A61K35/28 ,  A61K47/64 ,  A61K47/6425 ,  A61K47/6911 ,  A61K49/0041 ,  A61K49/0047 ,  A61K49/0084 ,  A61K2035/124 ,  C12N5/0006 ,  C12N5/0662 ,  C12N5/0663

Abstract: Described herein are compounds, compositions and methods for modification of the surface of a living cell with a therapeutically relevant targeting moiety. Also described herein are methods for treating disease states, such as acute myocardial ischemia or infarction, with said compositions, in a subject.

Abstract translation: 本文描述了用治疗相关靶向部分修饰活细胞表面的化合物，组合物和方法。 本文还描述了在受试者中用所述组合物治疗疾病状态的方法，例如急性心肌缺血或梗死。

公开(公告)号：US20250043023A1

公开(公告)日：2025-02-06

申请号：US18923514

申请日：2024-10-22

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA ,  UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： Youngwook WON ,  David A. BULL ,  Daniel Yongwon LEE

IPC: C07K16/32 ,  A61K47/60 ,  A61K47/68 ,  A61K47/69 ,  A61P35/00

Abstract: Surface-engineered immune cells, such as natural killer cells, grafted with targeting moiety-drug complexes. The present invention combines chemotherapy and immunotherapy by engineering the immune cells to target specific tumor cells through antigen recognition and deliver potent chemotherapeutic agents, thereby destroying the tumor cells. The surface-engineered immune cells may be prepared using a one-step method. The present invention also provides kits for preparing the surface-engineered immune cells.

公开(公告)号：US20210353768A1

公开(公告)日：2021-11-18

申请号：US17277828

申请日：2019-09-20

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA ,  UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： Youngwook WON ,  David A. BULL ,  Daniel Yongwon LEE

IPC: A61K47/69 ,  A61P35/00 ,  A61K47/68 ,  A61K47/60

Abstract: Surface-engineered immune cells, such as natural killer cells, grafted with targeting moiety-drug complexes. The present invention combines chemotherapy and immunotherapy by engineering the immune cells to target specific tumor cells through antigen recognition and deliver potent chemotherapeutic agents, thereby destroying the tumor cells. The surface-engineered immune cells may be prepared using a one-step method. The present invention also provides kits for preparing the surface-engineered immune cells.