公开(公告)号：US20200333346A1

公开(公告)日：2020-10-22

申请号：US16840713

申请日：2020-04-06

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： Andrew S. Dixon ,  Shawn Owen ,  Julio C. Delgado

IPC: G01N33/574 ,  C12Q1/66 ,  G01N33/58 ,  G01N33/542 ,  C07K16/24

Abstract: Split enzyme reporter systems are disclosed for detecting an analyte in a mixture. Fragments of the split enzyme may be covalently bound to targeting domains that bind to target regions of an analyte, thereby causing formation of an active complex. Some split enzyme reporter systems can be used to detect an analyte without the use of analyte immobilization, blocking, or wash steps. Some reporter systems also enable rapid detection of the analyte of interest.

公开(公告)号：US12253523B2

公开(公告)日：2025-03-18

申请号：US18453745

申请日：2023-08-22

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： Andrew S. Dixon ,  Shawn Owen

IPC: G01N33/574 ,  C07K16/24 ,  C12Q1/66 ,  C12Q1/6804 ,  G01N33/542 ,  G01N33/58

Abstract: Split enzyme reporter systems are disclosed for detecting an analyte in a mixture. Fragments of the split enzyme may be covalently bound to targeting domains that bind to target regions of an analyte, thereby causing formation of an active complex. Some split enzyme reporter systems can be used to detect an analyte without the use of analyte immobilization, blocking, or wash steps. Some reporter systems also enable rapid detection of the analyte of interest.

公开(公告)号：US20240210406A1

公开(公告)日：2024-06-27

申请号：US18453745

申请日：2023-08-22

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： Andrew S. Dixon ,  Shawn Owen

IPC: G01N33/574 ,  C07K16/24 ,  C12Q1/66 ,  C12Q1/6804 ,  G01N33/542 ,  G01N33/58

CPC classification number: G01N33/57488 ,  C07K16/241 ,  C12Q1/66 ,  G01N33/542 ,  G01N33/581 ,  C07K2317/24 ,  C12Q1/6804 ,  G01N2333/525

Abstract: Split enzyme reporter systems are disclosed for detecting an analyte in a mixture. Fragments of the split enzyme may be covalently bound to targeting domains that bind to target regions of an analyte, thereby causing formation of an active complex. Some split enzyme reporter systems can be used to detect an analyte without the use of analyte immobilization, blocking, or wash steps. Some reporter systems also enable rapid detection of the analyte of interest.

公开(公告)号：US11774453B2

公开(公告)日：2023-10-03

申请号：US16840713

申请日：2020-04-06

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： Andrew S. Dixon ,  Shawn Owen

IPC: G01N33/574 ,  G01N33/58 ,  G01N33/542 ,  C12Q1/66 ,  C07K16/24 ,  C12Q1/6804

CPC classification number: G01N33/57488 ,  C07K16/241 ,  C12Q1/66 ,  G01N33/542 ,  G01N33/581 ,  C07K2317/24 ,  C12Q1/6804 ,  G01N2333/525 ,  C12Q1/6804 ,  C12Q2563/103

Abstract: Split enzyme reporter systems are disclosed for detecting an analyte in a mixture. Fragments of the split enzyme may be covalently bound to targeting domains that bind to target regions of an analyte, thereby causing formation of an active complex. Some split enzyme reporter systems can be used to detect an analyte without the use of analyte immobilization, blocking, or wash steps. Some reporter systems also enable rapid detection of the analyte of interest.