公开(公告)号：US20230059785A1

公开(公告)日：2023-02-23

申请号：US17797630

申请日：2021-02-08

Applicant: University Health Network

Inventor： Li Zhang ,  Jongbok Lee ,  Aaron David Schimmer

IPC: A61K35/17 ,  A61K31/635 ,  A61P35/00

Abstract: Methods of treating T cells with Venetoclax to increase T cell-mediated cytotoxicity and/or T cell mediated anti-tumor activity are described. Also described are populations of enhanced T cells as well as associated methods and uses for the treatment of cancer.

公开(公告)号：US20150004696A1

公开(公告)日：2015-01-01

申请号：US14341232

申请日：2014-07-25

Applicant: Mayo Foundation for Medical Education and Research ,  University Health Network

Inventor： Rodger E. Tiedemann ,  Alexander Keith Stewart ,  Aaron David Schimmer ,  Xinliang Mao

IPC: A61K31/7076

CPC classification number: A61K31/7076 ,  A61K31/352 ,  A61K31/56 ,  A61K31/573 ,  A61K38/00 ,  C07K14/4738 ,  G01N33/566 ,  G01N33/6872 ,  A61K2300/00

Abstract: This document involves methods and materials related to inhibiting cyclin D polypeptide activity. For example, this document provides methods and materials that can be used to (1) identify mammals or cells in need of cyclin D polypeptide inhibition and (2) administer an agent capable of inhibiting cyclin D polypeptide activity.

Abstract translation: 本文件涉及与抑制细胞周期蛋白D多肽活性相关的方法和材料。 例如，本文件提供了可用于（1）识别需要细胞周期蛋白D多肽抑制的哺乳动物或细胞的方法和材料，以及（2）施用能够抑制细胞周期蛋白D多肽活性的试剂。