公开(公告)号：US10517937B2

公开(公告)日：2019-12-31

申请号：US15503916

申请日：2015-08-17

Applicant: University Health Network

Inventor： Li Zhang ,  Jong Bok Lee ,  Branson Chen

IPC: A61K35/17 ,  A61K39/00 ,  A61K31/7068

Abstract: Methods for the treatment of cancer using double negative (DN) T cells are described. The DNTs may be used for the treatment of chemotherapy-resistant cancers such as recurring or relapsing acute myeloid leukemia (AML). The use of allogenic DNTs, such as those derived from healthy donors, that do not exhibit toxicity towards normal host tissues and the complications associated with graft-versus-host-disease, is also described.