公开(公告)号：US20230011889A1

公开(公告)日：2023-01-12

申请号：US17782071

申请日：2020-12-07

Applicant: University Health Network

Inventor： Li Zhang ,  Jong Bok Lee ,  Daniel Vasic ,  Ismat Khatri ,  Dalam Ly ,  Yuki Sze Long Leung

IPC: A61K35/17 ,  C07K14/725 ,  C12N5/0783 ,  A61P35/00

Abstract: The disclosure relates to the development and use of CD4− CD8− double negative T (DNT) cells genetically modified to bind to one or more target antigens to enhance DNT cell anti-cancer activity such as with a chimeric antigen receptor (CAR). Genetically modified DNT cells can be generated ex vivo and expanded from allogeneic healthy donor cells and used as off-the-shelf therapy to overcome allogeneic graft-versus-host disease (GvHD) and/or host-versus-graft rejection in the treatment of cancer.