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公开(公告)号：US20190249143A1
公开(公告)日：2019-08-15
申请号：US16395625
申请日：2019-04-26
Applicant: University of Rochester
Inventor： James Palis , Samantha England , Ah Ram Kim
CPC classification number: C12N5/0641 , A61K35/18 , C12N2500/36 , C12N2500/90 , C12N2501/125 , C12N2501/14 , C12N2501/33 , C12N2501/39 , C12N2506/02 , C12N2510/00
Abstract: The present invention provides a human cell population that can self-renew extensively and yet retain the capacity to differentiate into red blood cells (RBCs). These cells are referred to as extensively self-renewing erythroblasts (ESREs). The cells of the invention serve among other things as a renewable source of transfusable RBCs.
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公开(公告)号：US20190194620A1
公开(公告)日：2019-06-27
申请号：US16288259
申请日：2019-02-28
Applicant: University of Rochester
Inventor： James Palis , Samantha England , Ah Ram Kim
CPC classification number: C12N5/0641 , A61K35/18 , C12N2500/36 , C12N2500/90 , C12N2501/125 , C12N2501/14 , C12N2501/33 , C12N2501/39 , C12N2506/02 , C12N2510/00
Abstract: The present invention provides a human cell population that can self-renew extensively and yet retain the capacity to differentiate into red blood cells (RBCs). These cells are referred to as extensively self-renewing erythroblasts (ESREs). The cells of the invention serve among other things as a renewable source of transfusable RBCs.
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公开(公告)号：US20160068810A1
公开(公告)日：2016-03-10
申请号：US14888110
申请日：2014-05-15
Applicant: UNIVERSITY OF ROCHESTER
Inventor： James Palis , Samantha England , Ah Ram Kim
CPC classification number: C12N5/0641 , A61K35/18 , C12N2500/36 , C12N2500/90 , C12N2501/125 , C12N2501/14 , C12N2501/33 , C12N2501/39 , C12N2506/02 , C12N2510/00
Abstract: The present invention provides a human cell population that can self-renew extensively and yet retain the capacity to differentiate into red blood cells (RBCs). These cells are referred to as extensively self-renewing erythroblasts (ESREs). The cells of the invention serve among other things as a renewable source of transfusable RBCs.
Abstract translation: 本发明提供了可以自我更新并且保持分化成红细胞（RBC）的能力的人类细胞群体。 这些细胞被称为广泛自我更新的成红细胞（ESRE）。 本发明的细胞可以用作可再生的可转染的RBC的来源。
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公开(公告)号：US10260043B2
公开(公告)日：2019-04-16
申请号：US14888110
申请日：2014-05-15
Applicant: UNIVERSITY OF ROCHESTER
Inventor： James Palis , Samantha England , Ah Ram Kim
Abstract: The present invention provides a human cell population that can self-renew extensively and yet retain the capacity to differentiate into red blood cells (RBCs). These cells are referred to as extensively self-renewing erythroblasts (ESREs). The cells of the invention serve among other things as a renewable source of transfusable RBCs.
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