公开(公告)号：US20230390342A1

公开(公告)日：2023-12-07

申请号：US18036085

申请日：2021-11-12

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： Jan L. Pierce ,  Zachary L. McCormick ,  John D. Phillips ,  Kevin T. Dustin

IPC: A61K35/50 ,  A61K31/728 ,  A61K45/06 ,  A61K9/00 ,  A61K9/19 ,  A61P29/00

CPC classification number: A61K35/50 ,  A61K31/728 ,  A61K45/06 ,  A61K9/0019 ,  A61K9/19 ,  A61P29/00

Abstract: Described herein are methods for treating radicular pain due to radiculopathies comprising administering a therapeutically effective amount of a composition comprising cell-free amniotic fluid.

公开(公告)号：US11466320B2

公开(公告)日：2022-10-11

申请号：US16413563

申请日：2019-05-15

Applicant: University of Utah Research Foundation

Inventor： John D. Phillips ,  Jennifer M. Heemstra

IPC: C12Q1/6874 ,  C12Q1/6806 ,  C12Q1/6876 ,  C12Q1/6816

Abstract: Branching phosphoramidite monomers and molecules having comb-like structures are disclosed and described. A branching phosphoramidite monomer having the structure is provided wherein R4 and R5 are independently —(O—CH2—CH2—)n where n is 1-5 or —O—(CH2—)n where n is 1-10, and R1, R2, and R3 are each one of dimethoxytrityl (DMT)—O—, levulinyl (Lev)—O—, and a phosphoramidite.

公开(公告)号：US20230295717A1

公开(公告)日：2023-09-21

申请号：US17963119

申请日：2022-10-10

Applicant: University of Utah Research Foundation

Inventor： John D. Phillips ,  Jennifer M. Heemstra

IPC: C12Q1/6874 ,  C12Q1/6806 ,  C12Q1/6876 ,  C12Q1/6816

CPC classification number: C12Q1/6874 ,  C12Q1/6806 ,  C12Q1/6876 ,  C12Q1/6816

Abstract: Branching phosphoramidite monomers and molecules having comb-like structures are disclosed and described. A branching phosphoramidite monomer having the structure




is provided wherein R4 and R5 are independently —(O—CH2—CH2—)n where n is 1-5 or —O—(CH2—)n where n is 1-10, and R1, R2, and R3 are each one of dimethoxytrityl (DMT)-O—, levulinyl (Lev)-O—, and a phosphoramidite.

公开(公告)号：US20230135928A1

公开(公告)日：2023-05-04

申请号：US17911624

申请日：2021-04-02

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： Jan L. Pierce ,  John D. Phillips ,  Kevin T. Dustin ,  Catherine Joy Lee ,  Daniel Couriel ,  Craig H. Selzman ,  Giavonni M. Lewis ,  Nathan Hatton ,  Joseph Edward Tonna

IPC: A61K35/50 ,  A61K47/36 ,  A61K9/19 ,  A61K9/00 ,  A61P11/00

Abstract: The present disclosure relates to a cell-free sterile filtered amniotic fluid that may be processed and/or supplemented to treat lung inflammation and/or fibrosis caused by lung disease.

公开(公告)号：US20200071756A1

公开(公告)日：2020-03-05

申请号：US16413563

申请日：2019-05-15

Applicant: University of Utah Research Foundation

Inventor： John D. Phillips ,  Jennifer M. Heemstra

IPC: C12Q1/6874 ,  C12Q1/6876 ,  C12Q1/6806 ,  C12Q1/6816

Abstract: Branching phosphoramidite monomers and molecules having comb-like structures are disclosed and described. A branching phosphoramidite monomer having the structure is provided wherein R4 and R5 are independently —(O—CH2-CH2—)n where n is 1-5 or —O—(CH2—)n where n is 1-10, and R1, R2, and R3 are each one of dimethoxytrityl (DMT)—O—, levulinyl (Lev)—O—, and a phosphoramidite.