公开(公告)号：US20210322559A1

公开(公告)日：2021-10-21

申请号：US17184289

申请日：2021-02-24

Applicant: University of Utah Research Foundation

Inventor： Julian Kessler ,  Michael S. Yu ,  Yang Li

IPC: A61K47/64 ,  C07K14/78 ,  A61K47/65 ,  G01N33/68

Abstract: Disclosed are peptide conjugates comprising an active agent, a spacer moiety, and a dimeric collagen hybridizing peptide comprising a first and second collagen hybridizing peptide, a linker; and a branch point, wherein the first and second collagen hybridizing peptides comprise the sequence of at least (GXY)n, wherein G is glycine, wherein X and Y are any amino acid, and wherein n is any number between 3 and 12. Also disclosed are methods of detecting denatured collagen in a sample comprising contacting a composition comprising any one of the disclosed peptide conjugates to a sample, wherein the active agent comprises a therapeutic agent, and detecting the presence or absence of binding of the peptide conjugate to denatured collagen, the presence of binding indicating the presence of denatured collagen in the sample. Also disclosed are methods of treating a disease or injury involving collagen damage comprising administering to a subject having a disease or injury involving collagen damage any one of the disclosed peptide conjugates.

公开(公告)号：US20170112940A1

公开(公告)日：2017-04-27

申请号：US15331348

申请日：2016-10-21

Applicant: University of Utah Research Foundation

Inventor： S. Michael Yu ,  Yang Li ,  Hendra Wahyudi

IPC: A61K51/00

CPC classification number: C07K7/08 ,  A61K38/00 ,  A61K49/0002 ,  C07K7/06

Abstract: Disclosed are peptide conjugates comprising an active agent, a spacer moiety, and a peptide, wherein the peptide comprises the sequence (Xaa1-Xaa2-Xaa3)n1-Xaa4-Xaa5-Xaa6-(Xaa7-Xaa8-Xaa9)n2, wherein Xaa1, Xaa2, Xaa3, Xaa4, Xaa5, Xaa6, Xaa7, Xaa8, Xaa9 is glycine, proline, a modified proline or aza-glycine, and at least one of Xaa1, Xaa2, Xaa3, Xaa4, Xaa5, Xaa6, Xaa7, Xaa8, or Xaa9 is aza-glycine. Disclosed are peptide conjugates comprising an active agent, a spacer moiety, and a peptide, wherein the peptide comprises the sequence (X1−Y1−Z1)-(X2−Y2−Z2)-(Xn−Yn−Zn) (SEQ ID NO:1-39, 82), wherein n=1-41, and X, Y, and Z are glycine, proline, a modified proline and/or aza-glycine, and at least one of the amino acids in the sequence is aza-glycine. Also disclosed are compositions and nanoparticles comprising these peptide conjugates. Also disclosed are methods of detecting and methods of treating using the peptide conjugates or compositions comprising the peptide conjugates.

公开(公告)号：US11684675B2

公开(公告)日：2023-06-27

申请号：US17184289

申请日：2021-02-24

Applicant: University of Utah Research Foundation

Inventor： Julian Kessler ,  Michael S. Yu ,  Yang Li

IPC: A61K47/64 ,  C07K14/78 ,  A61K47/65 ,  G01N33/68

CPC classification number: A61K47/641 ,  A61K47/64 ,  A61K47/65 ,  C07K14/78 ,  G01N33/6887 ,  G01N2333/78 ,  G01N2500/20

Abstract: Disclosed are peptide conjugates comprising an active agent, a spacer moiety, and a dimeric collagen hybridizing peptide comprising a first and second collagen hybridizing peptide, a linker; and a branch point, wherein the first and second collagen hybridizing peptides comprise the sequence of at least (GXY)n, wherein G is glycine, wherein X and Y are any amino acid, and wherein n is any number between 3 and 12. Also disclosed are methods of detecting denatured collagen in a sample comprising contacting a composition comprising any one of the disclosed peptide conjugates to a sample, wherein the active agent comprises a therapeutic agent, and detecting the presence or absence of binding of the peptide conjugate to denatured collagen, the presence of binding indicating the presence of denatured collagen in the sample. Also disclosed are methods of treating a disease or injury involving collagen damage comprising administering to a subject having a disease or injury involving collagen damage any one of the disclosed peptide conjugates.

公开(公告)号：US10953104B2

公开(公告)日：2021-03-23

申请号：US15547504

申请日：2016-01-29

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： Julian Kessler ,  Michael S. Yu ,  Yang Li

IPC: A61K47/64 ,  C07K14/78 ,  A61K47/65 ,  G01N33/68

Abstract: Disclosed are peptide conjugates comprising an active agent, a spacer moiety, and a dimeric collagen hybridizing peptide comprising a first and second collagen hybridizing peptide, a linker; and a branch point, wherein the first and second collagen hybridizing peptides comprise the sequence of at least (GXY)n, wherein G is glycine, wherein X and Y are any amino acid, and wherein n is any number between 3 and 12. Also disclosed are methods of detecting denatured collagen in a sample comprising contacting a composition comprising any one of the disclosed peptide conjugates to a sample, wherein the active agent comprises a therapeutic agent, and detecting the presence or absence of binding of the peptide conjugate to denatured collagen, the presence of binding indicating the presence of denatured collagen in the sample. Also disclosed are methods of treating a disease or injury involving collagen damage comprising administering to a subject having a disease or injury involving collagen damage any one of the disclosed peptide conjugates.

公开(公告)号：US20180000960A1

公开(公告)日：2018-01-04

申请号：US15547504

申请日：2016-01-29

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： Julian Kessler ,  Michael S. Yu ,  Yang Li

IPC: A61K47/64 ,  A61K47/65 ,  G01N33/68

CPC classification number: A61K47/641 ,  A61K47/64 ,  A61K47/65 ,  C07K14/78 ,  G01N33/6887 ,  G01N2333/78 ,  G01N2500/20

Abstract: Disclosed are peptide conjugates comprising an active agent, a spacer moiety, and a dimeric collagen hybridizing peptide comprising a first and second collagen hybridizing peptide, a linker; and a branch point, wherein the first and second collagen hybridizing peptides comprise the sequence of at least (GXY)n, wherein G is glycine, wherein X and Y are any amino acid, and wherein n is any number between 3 and 12. Also disclosed are methods of detecting denatured collagen in a sample comprising contacting a composition comprising any one of the disclosed peptide conjugates to a sample, wherein the active agent comprises a therapeutic agent, and detecting the presence or absence of binding of the peptide conjugate to denatured collagen, the presence of binding indicating the presence of denatured collagen in the sample. Also disclosed are methods of treating a disease or injury involving collagen damage comprising administering to a subject having a disease or injury involving collagen damage any one of the disclosed peptide conjugates.