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Patent Agency Ranking
公开(公告)号：US10123766B2
公开(公告)日：2018-11-13
申请号：US14359075
申请日：2012-12-10
Inventor： Pierre D. Mourad , Samuel R. Browd , Brian MacConaghy , Revathi Murthy , Nathaniel Coulson
Abstract: A stylet (100) includes a handle assembly (102) with an indicator display (112) and a stiff wire assembly (120) extending distally from the handle assembly (102) having a non-imaging ultrasonic device on a distal end. The stylet includes a circuit assembly having one or more of a pulser (120), a transmit/receive chip (132), a bandpass filter (134), a differential amplifier (136), an ADC (138), and an MCU (140), operable to control the operation of the ultrasonic device and to receive and analyze data from the ultrasonic device to facilitate implantation of a device such as a catheter.
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公开(公告)号：US20190282201A1
公开(公告)日：2019-09-19
申请号：US16163308
申请日：2018-10-17
Inventor： Pierre D. Mourad , Samuel R. Browd , Brian MacConaghy , Revathi Murthy , Nathaniel Coulson
Abstract: A stylet includes a handle assembly with an indicator display and a stiff wire assembly extending distally from the handle assembly having a non-imaging ultrasonic device on a distal end. The stylet includes a circuit assembly having one or more of a pulser, a transmit/receive chip, a bandpass filter, a differential amplifier, an ADC, and an MCU, operable to control the operation of the ultrasonic device and to receive and analyze data from the ultrasonic device to facilitate implantation of a device such as a catheter.
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3.发明申请Systems, Devices, and Methods for Separating, Concentrating, and/or Differentiating Between Cells from a Cell Sample 有权用于从细胞样品中分离，浓缩和/或分化细胞的系统，装置和方法公开(公告)号：US20150017678A1
公开(公告)日：2015-01-15
申请号：US14254611
申请日：2014-04-16
Inventor： Thomas Matula , Andrew A. Brayman , Oleg A. Sapozhnikov , Brian MacConaghy
CPC classification number: G01N21/53 , B01L3/502723 , B01L3/502761 , B01L3/502784 , B01L2200/0652 , B01L2200/0673 , B01L2300/0816 , B01L2300/0883 , B01L2400/0436 , G01N1/4077 , G01N21/6486 , G01N2001/4066 , G01N2015/1081 , G01N2021/6439
Abstract: Embodiments are generally related to differentiating and/or separating portions of a sample that are of interest from the remainder of the sample. Embodiments may be directed towards separating cells of interest from a cell sample. In some embodiments, acoustic impedances of the cells of interest may be modified. For example, the acoustic properties of the cells of interest may be modified by attaching bubbles to the cells of interest. The cell sample may then be subjected to an acoustic wave. The cells of interest may be differentiated and/or separated from the remainder of the sample based on relative displacements and/or volumetric changes experienced by the cells of interest in response thereto. The cells of interest may be separated using a standing wave and sorted into separate channels of a flow cell. Optionally, the cells may be interrogated by a light source and differentiated by signals generated in response thereto.
Abstract translation: 实施例通常涉及区分和/或分离样品的与样品其余部分有关的部分。 实施方案可以针对将感兴趣的细胞与细胞样品分离。 在一些实施例中，可以修改感兴趣的细胞的声阻抗。 例如，感兴趣的细胞的声学性质可以通过将气泡附着到感兴趣的细胞来修饰。 然后可以对电池样品进行声波。 感兴趣的细胞可以基于相应的位移和/或由感兴趣的细胞响应于其的体积变化而与样品的其余部分分离和/或分离。 感兴趣的细胞可以使用驻波分离并分类成流动池的分开的通道。 可选地，可以通过光源询问单元，并且通过响应于其产生的信号来区分单元。
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公开(公告)号：US09645080B2
公开(公告)日：2017-05-09
申请号：US14254611
申请日：2014-04-16
Inventor： Thomas Matula , Andrew A. Brayman , Oleg A. Sapozhnikov , Brian MacConaghy , Jarred Egan Swalwell , Camilo Perez
CPC classification number: G01N21/53 , B01L3/502723 , B01L3/502761 , B01L3/502784 , B01L2200/0652 , B01L2200/0673 , B01L2300/0816 , B01L2300/0883 , B01L2400/0436 , G01N1/4077 , G01N21/6486 , G01N2001/4066 , G01N2015/1081 , G01N2021/6439
Abstract: Embodiments are generally related to differentiating and/or separating portions of a sample that are of interest from the remainder of the sample. Embodiments may be directed towards separating cells of interest from a cell sample. In some embodiments, acoustic impedances of the cells of interest may be modified. For example, the acoustic properties of the cells of interest may be modified by attaching bubbles to the cells of interest. The cell sample may then be subjected to an acoustic wave. The cells of interest may be differentiated and/or separated from the remainder of the sample based on relative displacements and/or volumetric changes experienced by the cells of interest in response thereto. The cells of interest may be separated using a standing wave and sorted into separate channels of a flow cell. Optionally, the cells may be interrogated by a light source and differentiated by signals generated in response thereto.
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公开(公告)号：US20140323857A1
公开(公告)日：2014-10-30
申请号：US14359075
申请日：2012-12-10
Inventor： Pierre D. Mourad , Samuel R. Browd , Brian MacConaghy , Revathi Murthy , Nathaniel Coulson
CPC classification number: A61B8/0841 , A61B8/0808 , A61B8/0858 , A61B8/12 , A61B8/445 , A61B8/4483 , A61B8/4494 , A61B8/461 , A61B8/462 , A61B8/488 , A61B8/5207 , A61B8/54 , A61B8/56 , A61B17/00234 , A61B17/3421 , A61B17/3468 , A61B17/3478 , A61B90/11 , A61M25/09
Abstract: A stylet (100) includes a handle assembly (102) with an indicator display (112) and a stiff wire assembly (120) extending distally from the handle assembly (102) having a non-imaging ultrasonic device on a distal end. The stylet includes a circuit assembly having one or more of a pulser (120), a transmit/receive chip (132), a bandpass filter (134), a differential amplifier (136), an ADC (138), and an MCU (140), operable to control the operation of the ultrasonic device and to receive and analyze data from the ultrasonic device to facilitate implantation of a device such as a catheter.
Abstract translation: 探针（100）包括具有指示器显示器（112）的手柄组件（102）和从手柄组件（102）向远侧延伸的刚性线组件（120），其在远端具有非成像超声波装置。 探针包括具有脉冲发生器（120），发射/接收芯片（132），带通滤波器（134），差分放大器（136），ADC（138）和MCU（ 140），其可操作以控制超声波装置的操作并且接收和分析来自超声波装置的数据以便于诸如导管的装置的植入。
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