公开(公告)号：US10722557B2

公开(公告)日：2020-07-28

申请号：US16315684

申请日：2017-07-14

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Antonio Abbate ,  Stefano Toldo

IPC: A61P9/10 ,  A61K38/55 ,  A61K38/17 ,  A61P7/02 ,  C07K14/81 ,  C07K14/705

Abstract: Methods of preventing and/or treating reperfusion injury are provided. The methods involve administering alpha-2-macroglobulin (A2MG) to a subject with ischemia in one or more tissues or organs, in order to prevent or decrease reperfusion injury when blood flow is restored to the tissues or organs (reperfusion). In some aspects, the patient who is treated has had a heart attack (e.g. acute myocardial infarction, AMI) and the ischemic tissue that is protected from reperfusion injury is heart tissue.

公开(公告)号：US20200222516A1

公开(公告)日：2020-07-16

申请号：US16692954

申请日：2019-11-22

Applicant: The Regents of the University of Colorado, a body corporate ,  Virginia Commonwealth University

Inventor： Charles A. Dinarello ,  Antonio Abbate ,  Eli C. Lewis

IPC: A61K38/57 ,  C12Q1/02

Abstract: Embodiments herein report methods and compositions for treating cardiac conditions. In certain embodiments, compositions and methods relate to reducing, inhibiting or treating a subject having or suspected of undergoing cardiac remodeling after a cardiac event. Other embodiments herein relate to compounds including naturally occurring and synthetic compositions of alpha-1 antitrypsin and fragments thereof.

公开(公告)号：US10343985B2

公开(公告)日：2019-07-09

申请号：US14928450

申请日：2015-10-30

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Antonio Abbate ,  Shijun Zhang ,  Benjamin Van Tassell

IPC: C07C311/37 ,  C07C311/46 ,  C07C311/49

Abstract: Inhibitors that are anti-inflammatory agents are provided, as are methods of using the analogs to inhibit inflammation and prevent or treat diseases and conditions associated with inflammation, such as heart failure and autoimmune diseases.

公开(公告)号：US20170209555A1

公开(公告)日：2017-07-27

申请号：US15382474

申请日：2016-12-16

Applicant: The Regents of the University of Colorado, a body corporate ,  Virginia Commonwealth University

Inventor： Charles A. Dinarello ,  Antonio Abbate ,  Eli C. Lewis

IPC: A61K38/57 ,  C12Q1/02

CPC classification number: A61K38/57 ,  C12Q1/025

Abstract: Embodiments herein report methods and compositions for treating cardiac conditions. In certain embodiments, compositions and methods relate to reducing, inhibiting or treating a subject having or suspected of undergoing cardiac remodeling after a cardiac event. Other embodiments herein relate to compounds including naturally occurring and synthetic compositions of alpha-1 antitrypsin and fragments thereof.