公开(公告)号：US10722557B2

公开(公告)日：2020-07-28

申请号：US16315684

申请日：2017-07-14

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Antonio Abbate ,  Stefano Toldo

IPC: A61P9/10 ,  A61K38/55 ,  A61K38/17 ,  A61P7/02 ,  C07K14/81 ,  C07K14/705

Abstract: Methods of preventing and/or treating reperfusion injury are provided. The methods involve administering alpha-2-macroglobulin (A2MG) to a subject with ischemia in one or more tissues or organs, in order to prevent or decrease reperfusion injury when blood flow is restored to the tissues or organs (reperfusion). In some aspects, the patient who is treated has had a heart attack (e.g. acute myocardial infarction, AMI) and the ischemic tissue that is protected from reperfusion injury is heart tissue.