公开(公告)号：US09474602B2

公开(公告)日：2016-10-25

申请号：US14068284

申请日：2013-10-31

Applicant: WASEDA UNIVERSITY

Inventor： Mitsuo Umezu ,  Hitoshi Kasegawa

IPC: A61F2/24 ,  A61B17/32

CPC classification number: A61F2/2412 ,  A61B17/32 ,  A61F2/2415 ,  A61F2240/005 ,  A61F2250/0082

Abstract: An artificial mitral valve has a ring, an anterior cusp-side region, a posterior cusp-side region and a valve leaflet connected along an outer edge of the ring. The valve leaflet includes an anterior cusp forming member connected to the anterior cusp-side region and a posterior cusp forming member connected to the posterior cusp-side region. The anterior cusp forming member is provided with has an upper edge joined to the ring and a lower edge that forms a bifurcated portion. The upper edge is made up of a pair of right and left edges that incline inward and upward from the right and left sides, and a curved edge interposed between the inclined edges that curves along the anterior cusp-side region. The posterior cusp forming member has an upper edge joined to the ring and a lower edge that forms a bifurcated portion.

Abstract translation: 人造二尖瓣具有环，前尖部侧区域，后尖端侧区域和沿着环的外边缘连接的瓣膜小​​叶。 瓣叶包括连接到前尖部侧区域的前牙尖形成构件和连接到后尖端侧区域的后牙尖形成构件。 前牙尖形成构件具有连接到环的上边缘和形成分叉部分的下边缘。 上边缘由从左右侧向内和向上倾斜的一对左右边缘构成，并且设置在沿着前尖点侧区域弯曲的倾斜边缘之间的弯曲边缘。 后牙尖形成构件具有连接到环的上边缘和形成分叉部分的下边缘。

公开(公告)号：US20140058503A1

公开(公告)日：2014-02-27

申请号：US14068284

申请日：2013-10-31

Applicant: WASEDA UNIVERSITY

Inventor： Mitsuo Umezu ,  Hitoshi Kasegawa

IPC: A61F2/24 ,  A61B17/32

CPC classification number: A61F2/2412 ,  A61B17/32 ,  A61F2/2415 ,  A61F2240/005 ,  A61F2250/0082

Abstract: An artificial mitral valve has a ring, an anterior cusp-side region, a posterior cusp-side region and a valve leaflet connected along an outer edge of the ring. The valve leaflet includes an anterior cusp forming member connected to the anterior cusp-side region and a posterior cusp forming member connected to the posterior cusp-side region. The anterior cusp forming member is provided with has an upper edge joined to the ring and a lower edge that forms a bifurcated portion. The upper edge is made up of a pair of right and left edges that incline inward and upward from the right and left sides, and a curved edge interposed between the inclined edges that curves along the anterior cusp-side region. The posterior cusp forming member has an upper edge joined to the ring and a lower edge that forms a bifurcated portion.

Abstract translation: 人造二尖瓣具有环，前尖部侧区域，后尖端侧区域和沿着环的外边缘连接的瓣膜小​​叶。 瓣叶包括连接到前尖部侧区域的前牙尖形成构件和连接到后尖端侧区域的后牙尖形成构件。 前牙尖形成构件具有连接到环的上边缘和形成分叉部分的下边缘。 上边缘由从左右侧向内和向上倾斜的一对左右边缘构成，并且设置在沿着前尖点侧区域弯曲的倾斜边缘之间的弯曲边缘。 后牙尖形成构件具有连接到环的上边缘和形成分叉部分的下边缘。

公开(公告)号：US10660977B2

公开(公告)日：2020-05-26

申请号：US14389269

申请日：2013-04-01

Applicant: WASEDA UNIVERSITY

Inventor： Kiyotaka Iwasaki ,  Mitsuo Umezu

IPC: A61L2/00 ,  A61L27/36 ,  A01N1/02

Abstract: The present invention suppresses the strength reduction or degeneration of a tissue after the tissue is dried and/or sterilized, for the tissue comprising biological components and the like. Specifically, biological tissue is immersed in a trehalose solution and shaken, thereby impregnating the biological tissue with the trehalose solution. The trehalose solution used here is one obtained by dissolving trehalose in a phosphate buffered saline, the concentration of trehalose being preferably in the range of 20 wt % to 35 wt %. Thereafter, the biological tissue is dried to remove moisture in the biological tissue, and sterilized with ethylene oxide gas.

公开(公告)号：US20150064228A1

公开(公告)日：2015-03-05

申请号：US14389269

申请日：2013-04-01

Applicant: WASEDA UNIVERSITY

Inventor： Kiyotaka Iwasaki ,  Mitsuo Umezu

IPC: A61L2/00 ,  A61L27/36

CPC classification number: A61L2/0094 ,  A01N1/0221 ,  A01N1/0226 ,  A61L27/3687 ,  A61L2430/40

Abstract: The present invention suppresses the strength reduction or degeneration of a tissue after the tissue is dried and/or sterilized, for the tissue comprising biological components and the like. Specifically, biological tissue is immersed in a trehalose solution and shaken, thereby impregnating the biological tissue with the trehalose solution. The trehalose solution used here is one obtained by dissolving trehalose in a phosphate buffered saline, the concentration of trehalose being preferably in the range of 20 wt % to 35 wt %. Thereafter, the biological tissue is dried to remove moisture in the biological tissue, and sterilized with ethylene oxide gas.

Abstract translation: 本发明抑制组织干燥和/或灭菌后对于包含生物成分的组织等的组织的强度降低或变性。 具体地，将生物组织浸入海藻糖溶液中并摇动，从而用海藻糖溶液浸渍生物组织。 这里使用的海藻糖溶液是通过将海藻糖溶解在磷酸盐缓冲盐水中而获得的，海藻糖的浓度优选在20重量％〜35重量％的范围内。 此后，将生物组织干燥以除去生物组织中的水分，并用环氧乙烷气体灭菌。