公开(公告)号：US12243731B2

公开(公告)日：2025-03-04

申请号：US17682391

申请日：2022-02-28

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： Jose De Corral

IPC: H01J49/00 ,  G01N30/86 ,  G06F17/00 ,  G01N30/72 ,  G01N30/88

Abstract: Described are techniques for processing data. Sample analysis is performed generating scans of data. Each scan comprises a set of data elements each associating an ion intensity count with a plurality of dimensions including a retention time dimension and a mass to charge ratio dimension. The scans are analyzed to identify one or more ion peaks. Analyzing includes filtering a first plurality of the scans producing a first plurality of filtered output scans. The filtering including first filtering producing a first filtering output, wherein the first filtering includes executing a plurality of threads in parallel which apply a first filter to the first plurality of scans to produce the first filtering output. Each of the plurality of threads computes at least one filtered output point for at least one corresponding input point included in the plurality of scans. Analyzing includes detecting one or more peaks using the filtered output scans.

公开(公告)号：US10335753B2

公开(公告)日：2019-07-02

申请号：US14830611

申请日：2015-08-19

Applicant: Waters Technologies Corporation

Inventor： Jose De Corral ,  Neal B. Almeida

IPC: B01F3/08 ,  B01F5/00 ,  B01F5/02 ,  B01F5/06 ,  B01D15/16 ,  B01F15/02 ,  G01N30/06 ,  G01N30/34

Abstract: Disclosed is an assembly for mixing fluids (i.e., gases or liquids), and more particularly an assembly that accurately mixes two or more high-pressure fluid sources and is adapted for use in applications, such as for example, chromatography. The mixer assembly (100) includes, inter alia, a housing (10), an inlet fitting (40), and a mixer cartridge assembly (60). The housing (10) has a fluid receiving section (16) and a fluid discharge section (18) with an outlet (20) formed therein. A central bore (22) extends between the fluid receiving section (16) and fluid discharge section (18). An inlet fitting (40) is engaged with the housing (10) and has first (42) and second (44) fluid ports formed therein that extend from the fitting exterior to the fluid receiving section (16) of the housing (10). A mixer cartridge assembly (60) is disposed within the central bore (22) of the housing (10) and is positioned between the inlet fitting (40) and the downstream end portion of the housing (10). The mixer cartridge assembly (60) includes a body portion (64), a plurality of spheres disposed within a central mixing chamber (62) formed in the body portion (64), and mechanism for retaining the spheres in the mixing chamber (62).

公开(公告)号：US20160184786A1

公开(公告)日：2016-06-30

申请号：US14830611

申请日：2015-08-19

Applicant: Waters Technologies Corporation

Inventor： Jose De Corral ,  Neal B. Almeida

IPC: B01F15/02 ,  B01F3/08 ,  G01N30/06 ,  B01F5/06

CPC classification number: B01F15/0243 ,  B01D15/166 ,  B01F3/0861 ,  B01F5/0077 ,  B01F5/0268 ,  B01F5/0602 ,  B01F5/0695 ,  B01F5/0696 ,  G01N30/06 ,  G01N30/34 ,  G01N2030/347

Abstract: Disclosed is an assembly for mixing fluids (i.e., gases or liquids), and more particularly an assembly that accurately mixes two or more high-pressure fluid sources and is adapted for use in applications, such as for example, chromatography. The mixer assembly (100) includes, inter alia, a housing (10), an inlet fitting (40), and a mixer cartridge assembly (60). The housing (10) has a fluid receiving section (16) and a fluid discharge section (18) with an outlet (20) formed therein. A central bore (22) extends between the fluid receiving section (16) and fluid discharge section (18). An inlet fitting (40) is engaged with the housing (10) and has first (42) and second (44) fluid ports formed therein that extend from the fitting exterior to the fluid receiving section (16) of the housing (10). A mixer cartridge assembly (60) is disposed within the central bore (22) of the housing (10) and is positioned between the inlet fitting (40) and the downstream end portion of the housing (10). The mixer cartridge assembly (60) includes a body portion (64), a plurality of spheres disposed within a central mixing chamber (62) formed in the body portion (64), and mechanism for retaining the spheres in the mixing chamber (62).

Abstract translation: 公开了一种用于混合流体（即，气体或液体）的组件，更具体地说，一种精确混合两种或更多种高压流体源并适用于诸如色谱法的应用的组件。 混合器组件（100）尤其包括壳体（10），入口配件（40）和混合器筒组件（60）。 壳体（10）具有在其中形成有出口（20）的流体接收部分（16）和流体排出部分（18）。 中心孔（22）在流体接收部分（16）和流体排放部分（18）之间延伸。 入口配件（40）与壳体（10）接合并且具有形成在其中的第一（42）和第二（44）流体端口，其从配件外部延伸到壳体（10）的流体接收部分（16）。 混合器筒组件（60）设置在壳体（10）的中心孔（22）内并且位于入口配件（40）和壳体（10）的下游端部分之间。 混合器筒组件（60）包括主体部分（64），设置在形成于主体部分（64）中的中心混合室（62）内的多个球体，以及用于将球体保持在混合室（62）中的机构， 。

公开(公告)号：US20150123825A1

公开(公告)日：2015-05-07

申请号：US14526574

申请日：2014-10-29

Applicant: Waters Technologies Corporation

Inventor： Jose De Corral

IPC: H03M7/30 ,  H01J49/26

CPC classification number: H03M7/30 ,  H01J49/0036 ,  H01J49/26 ,  H03M7/3059

Abstract: Techniques are described for performing data compression of a first data set including data points in a plurality of dimensions. First processing is performed to determine a second set of final sums. For each data point in the first data set, a corresponding final sum of the second set is determined that is a sum of intensities associated with a first portion of data points, wherein the first portion of data points for which the intensities are summed for said each data point are included within a geometric shape centered on said each data point. Second processing is performed to determine a final set of final combined keep values. Each of the final combined keep values corresponds to a different one of the data points in the first data set and denotes whether to keep or otherwise remove the different one of the data points from the first data set.

Abstract translation: 描述了用于执行包括多个维度中的数据点的第一数据集的数据压缩的技术。 执行第一处理以确定第二组最终和。 对于第一数据集中的每个数据点，确定第二集合的对应的最终和，其是与数据点的第一部分相关联的强度之和，其中对于所述第一部分的强度相加的数据点的第一部分 每个数据点被包括在以所述每个数据点为中心的几何形状内。 执行第二处理以确定最终组合保持值的最终集合。 最终组合保持值中的每一个对应于第一数据集中的不同的一个数据点，并且表示是否保留或以其他方式从第一数据集中删除不同的一个数据点。