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1.发明申请公开(公告)号：US20190195758A1
公开(公告)日：2019-06-27
申请号：US16230567
申请日：2018-12-21
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： Bonnie A. Alden , Kenneth Berthelette , Jon Finch , Donna Osterman , Thomas Swann , Thomas H. Walter
CPC classification number: G01N1/405 , B01D15/327 , B01D15/362 , B01D15/3847 , B01D15/426 , B01J39/05 , B01J39/26 , G01N2030/009 , G01N2030/062
Abstract: In various aspects, the present disclosure pertains to methods of performing a sample enrichment procedure, which comprise: adding a sample fluid that comprises at least one phospholipid and at least one target analyte to a sorbent that comprises a hydrophobic component and a cation exchange component, thereby resulting in sorbent with bound phospholipid and bound target analyte; adding an aqueous solution comprising an acidic compound and a salt; adding an organic solution to the sorbent thereby desorbing at least a portion of the bound phospholipid from the sorbent; and adding an elution solution to the sorbent, thereby desorbing at least a portion of the bound target analyte from the sorbent and forming a solution of the target analyte in the elution solution. In other aspects, the present disclosure pertains to kits, which may be used in conjunction with such methods.
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公开(公告)号：US20220082532A1
公开(公告)日：2022-03-17
申请号：US17471449
申请日：2021-09-10
Applicant: Waters Technologies Corporation
Inventor： Amit Patel , Moon Chul Jung , Susan Rzewuski , Thomas H. Walter , Matthew A. Lauber , Kevin Wyndham , Mathew DeLano , Jennifer Simeone
Abstract: The present disclosure is directed to methods for evaluating system inertness, such as the inertness of a LC or other fluidic system. Some methods are directed to tests wherein the column has been removed prior to injecting a sample including a positive (e.g., metal reacting moiety) control into the system. Some methods can include: (1) repeatedly injecting the sample into a system, the system comprising: fluidic paths wherein interior surfaces of the fluidic paths define wetted surfaces, and wherein at least a portion of the wetted surfaces of the fluidic flow path are coated with an inert coating, wherein the inert coating is inert to at least one analyte in the sample; (2) detecting a value associated with the positive control; and (3) analyzing values associated with the detected positive control to determine system inertness.
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3.发明申请公开(公告)号：US20130319086A1
公开(公告)日：2013-12-05
申请号：US13750511
申请日：2013-01-25
Applicant: Waters Technologies Corporation
Inventor： Kevin Daniel Wyndham , Pamela C. Iraneta , Thomas H. Walter
CPC classification number: B01D15/36 , B01D15/1871 , B01D15/327 , B01D15/3833 , B01D15/3847 , B01J20/286 , B01J20/29 , B01J20/3204 , B01J20/3236 , B01J20/3257 , B01J20/3285 , B01J2220/52 , B01J2220/54 , B01J2220/58 , G01N30/90
Abstract: The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for its preparation and separations devices containing the chromatographic material; separations devices, chromatographic columns and kits comprising the same; and methods for the preparation thereof. The chromatographic materials of the invention are high purity chromatographic materials comprising a chromatographic surface wherein the chromatographic surface comprises a hydrophobic surface group and one or more ionizable modifier.
Abstract translation: 本发明提供了新颖的色谱材料，例如用于色谱分离，其制备方法和含有色谱材料的分离装置; 分离装置，色谱柱和包含它们的试剂盒; 及其制备方法。 本发明的色谱材料是包含色谱表面的高纯度色谱材料，其中色谱表面包含疏水表面基团和一种或多种可离子化的改性剂。
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公开(公告)号：US20250052727A1
公开(公告)日：2025-02-13
申请号：US18933343
申请日：2024-10-31
Applicant: Waters Technologies Corporation
Inventor： Edouard S. P. Bouvier , Kevin Wyndham , Thomas H. Walter , Uwe D. Neue
IPC: G01N30/02 , B01D15/34 , B01J20/28 , B01J20/282 , B01J20/286 , G01N21/53
Abstract: The present invention is directed to a device and a method for performing size exclusion chromatography. Embodiments of the present invention feature devices and methods for size exclusion chromatography at normal high performance liquid chromatography or ultra performance liquid chromatography pressures and above using small particles.
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5.发明授权公开(公告)号：US11604123B2
公开(公告)日：2023-03-14
申请号：US16230567
申请日：2018-12-21
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： Bonnie A. Alden , Kenneth Berthelette , Jon Finch , Donna Osterman , Thomas Swann , Thomas H. Walter
IPC: G01N1/40 , B01D15/38 , B01D15/42 , B01D15/36 , B01J39/26 , B01J39/05 , B01D15/32 , G01N33/92 , G01N30/06 , G01N30/00
Abstract: In various aspects, the present disclosure pertains to methods of performing a sample enrichment procedure, which comprise: adding a sample fluid that comprises at least one phospholipid and at least one target analyte to a sorbent that comprises a hydrophobic component and a cation exchange component, thereby resulting in sorbent with bound phospholipid and bound target analyte; adding an aqueous solution comprising an acidic compound and a salt; adding an organic solution to the sorbent thereby desorbing at least a portion of the bound phospholipid from the sorbent; and adding an elution solution to the sorbent, thereby desorbing at least a portion of the bound target analyte from the sorbent and forming a solution of the target analyte in the elution solution. In other aspects, the present disclosure pertains to kits, which may be used in conjunction with such methods.
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Patent Agency Ranking
公开(公告)号：US20220091079A1
公开(公告)日：2022-03-24
申请号：US17471463
申请日：2021-09-10
Applicant: Waters Technologies Corporation
Inventor： Amit Patel , Moon Chul Jung , Susan Rzewuski , Matthew A. Lauber , Thomas H. Walter , Kevin Wyndham , Mathew DeLano , Jennifer Simeone
IPC: G01N30/88
Abstract: The present disclosure is directed to a kit for evaluating system inertness. The kit includes a positive control comprising a metal interacting moiety, and a negative control that does not contain a metal interacting moiety. In some embodiments the kit also includes a container to hold a system suitability solution (e.g., an equimolar mixture of the positive control and the negative control).
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7.发明申请公开(公告)号：US20220082531A1
公开(公告)日：2022-03-17
申请号：US17471393
申请日：2021-09-10
Applicant: Waters Technologies Corporation
Inventor： Amit Patel , Moon Chul Jung , Susan Rzewuski , Thomas H. Walter , Matthew A. Lauber , Kevin Wyndham , Mathew DeLano , Jennifer Simeone
IPC: G01N30/04
Abstract: The present disclosure is directed to methods of characterizing a system containing a chromatographic column. The methods can include introducing a sample comprising a positive control and a negative control to the system containing a chromatographic column, wherein the positive control is a sensitive probe that interacts with the system and the negative control is substantially non-interacting with the system; after passing the sample through the chromatographic column, detecting the positive control and the negative control; and determining system suitability by comparing the amount of detected positive control to negative control. In some embodiments, determining system suitability (e.g., inertness of sample to the system) is accomplished by determining a ratio of detected positive control to negative control.
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公开(公告)号：US10974167B2
公开(公告)日：2021-04-13
申请号：US16202504
申请日：2018-11-28
Applicant: Waters Technologies Corporation
Inventor： Kevin D. Wyndham , Pamela C. Iraneta , Thomas H. Walter
Abstract: The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for its preparation and separations devices containing the chromatographic material; separations devices, chromatographic columns and kits comprising the same; and methods for the preparation thereof. The chromatographic materials of the invention are high purity chromatographic materials comprising a chromatographic surface wherein the chromatographic surface comprises a hydrophobic surface group and one or more ionizable modifier.
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公开(公告)号：US10800799B2
公开(公告)日：2020-10-13
申请号：US15941338
申请日：2018-03-30
Applicant: Waters Technologies Corporation
Inventor： Pamela C. Iraneta , Thomas H. Walter , Xin Zhang , Daniel P. Walsh , Kevin D. Wyndham , Raymond P. Fisk
IPC: B01D15/00 , B01J20/00 , G01N1/00 , C07F9/10 , B01D15/32 , B01J20/28 , B01J20/287 , B01J20/32 , B01J20/10 , B01D15/22 , B01L3/00 , C07K1/30 , G01N30/88
Abstract: Methods, kits and devices for separating phospholipids and proteins from small molecules in biochemical samples can feature an apparatus having a wetting barrier, at least one frit and a separation media. For example, an apparatus can include at least one wall defining a chamber having an exit and an entrance; a wetting barrier disposed between the exit and entrance, so as to define a separation media space located between the wetting barrier and the exit and a sample receiving area located between the wetting barrier and the entrance; and a separation media disposed adjacent to the wetting barrier and having a specific affinity for phospholipids.
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公开(公告)号：US20190091606A1
公开(公告)日：2019-03-28
申请号：US16202504
申请日：2018-11-28
Applicant: Waters Technologies Corporation
Inventor： Kevin D. Wyndham , Pamela C. Iraneta , Thomas H. Walter
Abstract: The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for its preparation and separations devices containing the chromatographic material; separations devices, chromatographic columns and kits comprising the same; and methods for the preparation thereof. The chromatographic materials of the invention are high purity chromatographic materials comprising a chromatographic surface wherein the chromatographic surface comprises a hydrophobic surface group and one or more ionizable modifier.
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