公开(公告)号：US20040021771A1

公开(公告)日：2004-02-05

申请号：US10606976

申请日：2003-06-25

Applicant: Xenogen Corporation

Inventor： Daniel G. Stearns ,  Bradley W. Rice ,  Michael D. Cable

IPC: H04N007/18

CPC classification number: G01N21/763 ,  A61K49/0013 ,  G01B9/02004 ,  G01B9/0203 ,  G01B9/02041 ,  G01B11/24 ,  G01B11/2518 ,  G01N21/6456 ,  H04N13/204 ,  H04N13/25 ,  H04N13/271

Abstract: The present invention provides systems and methods for obtaining a three-dimensional (3D) representation of one or more light sources inside a sample, such as a mammal. Mammalian tissue is a turbid medium, meaning that photons are both absorbed and scattered as they propagate through tissue. In the case where scattering is large compared with absorption, such as red to near-infrared light passing through tissue, the transport of light within the sample is described by diffusion theory. Using imaging data and computer-implemented photon diffusion models, embodiments of the present invention produce a 3D representation of the light sources inside a sample, such as a 3D location, size, and brightness of such light sources.

Abstract translation: 本发明提供用于获得样品（例如哺乳动物）内的一个或多个光源的三维（3D）表示的系统和方法。 哺乳动物组织是一种混浊的培养基，这意味着光子在通过组织传播时被吸收和分散。 在与吸收相比散射大的情况下，例如通过组织的红色至近红外光，通过扩散理论描述样品内的光的传输。 使用成像数据和计算机实现的光子扩散模型，本发明的实施例产生样品内的光源的3D表示，例如这种光源的3D位置，尺寸和亮度。