公开(公告)号：US20030193517A1

公开(公告)日：2003-10-16

申请号：US10458579

申请日：2003-06-09

Applicant: Xenogen Corporation

Inventor： Michael D. Cable

IPC: G09G005/00

CPC classification number: G06T7/0012 ,  A61B5/0059 ,  A61B5/743 ,  A61B5/7435 ,  A61B2503/40 ,  A61B2560/0223 ,  G06F3/0481 ,  G06F19/00 ,  G06F19/321 ,  G06T19/00 ,  G06T2200/24 ,  G06T2207/10004 ,  G06T2207/20104 ,  G06T2207/30004 ,  G06T2210/41

Abstract: A graphical user interface is provided which allows the user to perform numerous operations suitable for analysis of in-vivo images within a single display screen or a single window. Using the the-vivo GUI, the user may create and manipulate analysis tools such as rectangle and ellipse tools to define regions of interest and perform various measurements on an in-vivo image. In addition, the GUI allows the user to store measurement results in a dated electronic notebook, display testing information, manipulate image presentation and print while maintaining view of the image.

公开(公告)号：US20040127781A1

公开(公告)日：2004-07-01

申请号：US09795056

申请日：2001-02-21

Applicant: Xenogen Corporation

Inventor： Michael D. Cable ,  Michael Bo Nelson ,  Bradley W. Rice ,  Christopher A. Rasco ,  David N. Sprague ,  David G. Nilson ,  Rick Dalgetty

IPC: H04N005/225 ,  G01T001/10

CPC classification number: G02B27/0018 ,  G01N21/01 ,  G02B21/16

Abstract: An improved imaging apparatus is disclosed that allows a user to perform numerous imaging operations. The imaging apparatus may include one or more improvements to imaging box design to improve illumination control within the imaging box, such as improved door seal arrangements, improved door closing mechanisms, and improved light seals. The present invention may also include one or more improvements to imaging apparatus design to facilitate image capture, such as: an automated filter select device, a moveable stage, automated focus control, f-stop adjustment and stage height, and improved internal illumination for capturing photographic images.

Abstract translation: 公开了一种改进的成像装置，其允许用户执行许多成像操作。 成像装置可以包括对成像盒设计的一个或多个改进以改善成像盒内的照明控制，例如改进的门密封装置，改进的门关闭机构和改进的光密封。 本发明还可以包括对成像装置设计的一个或多个改进以便于图像捕获，例如：自动滤波器选择装置，可移动台，自动对焦控制，f-停止调整和台高度，以及用于捕获的改进的内部照明 摄影图像。

公开(公告)号：US20040021771A1

公开(公告)日：2004-02-05

申请号：US10606976

申请日：2003-06-25

Applicant: Xenogen Corporation

Inventor： Daniel G. Stearns ,  Bradley W. Rice ,  Michael D. Cable

IPC: H04N007/18

CPC classification number: G01N21/763 ,  A61K49/0013 ,  G01B9/02004 ,  G01B9/0203 ,  G01B9/02041 ,  G01B11/24 ,  G01B11/2518 ,  G01N21/6456 ,  H04N13/204 ,  H04N13/25 ,  H04N13/271

Abstract: The present invention provides systems and methods for obtaining a three-dimensional (3D) representation of one or more light sources inside a sample, such as a mammal. Mammalian tissue is a turbid medium, meaning that photons are both absorbed and scattered as they propagate through tissue. In the case where scattering is large compared with absorption, such as red to near-infrared light passing through tissue, the transport of light within the sample is described by diffusion theory. Using imaging data and computer-implemented photon diffusion models, embodiments of the present invention produce a 3D representation of the light sources inside a sample, such as a 3D location, size, and brightness of such light sources.

Abstract translation: 本发明提供用于获得样品（例如哺乳动物）内的一个或多个光源的三维（3D）表示的系统和方法。 哺乳动物组织是一种混浊的培养基，这意味着光子在通过组织传播时被吸收和分散。 在与吸收相比散射大的情况下，例如通过组织的红色至近红外光，通过扩散理论描述样品内的光的传输。 使用成像数据和计算机实现的光子扩散模型，本发明的实施例产生样品内的光源的3D表示，例如这种光源的3D位置，尺寸和亮度。

公开(公告)号：US20030036860A1

公开(公告)日：2003-02-20

申请号：US10177647

申请日：2002-06-20

Applicant: Xenogen Corporation

Inventor： Bradley Rice ,  Michael D. Cable

IPC: G01R015/00 ,  G06F019/00

CPC classification number: G01J1/08 ,  G01N21/278 ,  G01N21/763 ,  H04N5/217

Abstract: The invention describes systems and methods to obtain and present imaging data in absolute units. The systems and methods convert relative image data produced by a camera to absolute light intensity data using a compensation factor. The compensation factor accommodates for hardware and specific imaging conditions in the imaging system that variably affect camera output. The present invention determines the compensation factor based on assessing the output of the camera against a known light source for a specific set of imaging conditions in the imaging system. The compensation factor is then stored in memory corresponding to the specific set of imaging conditions. Upon subsequent imaging with the set of imaging conditions, the corresponding compensation factor is called from memory and applied to the camera output. A compensation factor may be determined and stored for each hardware state and imaging condition available to the imaging system.

Abstract translation: 本发明描述以绝对单位获得和呈现成像数据的系统和方法。 系统和方法使用补偿因子将相机产生的相对图像数据转换为绝对光强度数据。 补偿系数适用于可变影响摄像机输出的成像系统中的硬件和特定成像条件。 本发明基于针对成像系统中的特定成像条件集合的已知光源的照相机的评估来确定补偿因子。 然后将补偿因子存储在与特定成像条件对应的存储器中。 随着成像条件的集合的后续成像，从存储器调用相应的补偿因子并将其应用于相机输出。 可以为成像系统可用的每个硬件状态和成像条件确定和存储补偿因子。