公开(公告)号：US20150065377A1

公开(公告)日：2015-03-05

申请号：US14469563

申请日：2014-08-26

Applicant: YOKOGAWA ELECTRIC CORPORATION

Inventor： Takashi TADENUMA ,  Tomoyuki TAGUCHI ,  Takeo TANAAMI

IPC: C12Q1/68

CPC classification number: C12Q1/6818 ,  C12Q1/6834 ,  Y10T436/143333 ,  C12Q2537/1373 ,  C12Q2537/161

Abstract: A nucleic acid sequence measuring method includes measuring fluorescence from the nucleic acid sequence measuring device supplied with a sample solution. The device includes a fluorescent probe added with a fluorescent molecule, and a quenching probe added with a quenching substance. The fluorescent probe and/or the quenching probe has a detection part detecting a particular nucleic acid sequence. Fluorescence from the fluorescent molecule is quenched by the quenching substance coupled with the fluorescent molecule when the hybridization between the detection target nucleic acid and the detection part has not occurred, and fluorescence is emitted from the fluorescent molecule separated from the quenching substance when the hybridization has occurred.

Abstract translation: 核酸序列测量方法包括测量来自提供有样品溶液的核酸序列测量装置的荧光。 该装置包括添加有荧光分子的荧光探针和加入淬灭物质的淬灭探针。 荧光探针和/或猝灭探针具有检测特定核酸序列的检测部分。 当检测对象核酸和检测部分之间的杂交没有发生时，荧光分子的荧光被与荧光分子偶联的猝灭物质猝灭，当杂交具有杂质时，从与猝灭物质分离的荧光分子发出荧光 发生。

公开(公告)号：US20210325305A1

公开(公告)日：2021-10-21

申请号：US16479806

申请日：2018-01-12

Applicant: Yokogawa Electric Corporation

Inventor： Takeo TANAAMI ,  Tomoyuki TAGUCHI ,  Yuki MIYAUCHI

IPC: G01N21/64

Abstract: To reduce optical noise in fluorescence measurement. A biochip 110 for fluorescence measurement includes a transparent substrate 111, multiple microlenses 112 dispersively formed on a first surface 111a of the transparent substrate 111, multiple protruding portions 113 formed corresponding one-to-one with the microlenses 112 on a second surface 111b of the transparent substrate 111, and a fluorescence measurement site 114 formed at a top portion of each protruding portion 113.

公开(公告)号：US20140125981A1

公开(公告)日：2014-05-08

申请号：US14072812

申请日：2013-11-06

Applicant: YOKOGAWA ELECTRIC CORPORATION

Inventor： Mitsuhiro IGA ,  Takeo TANAAMI ,  Nobuyuki KAKURYU

IPC: G01J3/46

CPC classification number: G01J3/46 ,  G01J3/0235 ,  G01J3/26 ,  G01J3/32 ,  G01J3/51 ,  G01J2003/1221 ,  G01J2003/1226 ,  G01J2003/1243 ,  G01J2003/1247 ,  G02B26/008

Abstract: A spectroscopic apparatus includes an optical system configured to transmit output light from a sample irradiated with irradiation light from a light source, a two-dimensional array light detector configured to photograph light transmitted through the optical system, and a control unit. The optical system includes a first optical device disposed between the sample and the two-dimensional array light detector, a second optical device disposed between the two-dimensional array light detector and the first optical device, and a variable band-pass filter disposed in at least one of spaces between the first optical device and the sample and between the second optical device and the two-dimensional array light detector. The control unit changes a light transmission wavelength band of the variable band-pass filter in accordance with a photographing timing of the two-dimensional array light detector.

Abstract translation: 分光装置包括：光学系统，被配置为从来自光源的照射光照射的样品传输输出光;二维阵列光检测器，被配置为拍摄通过光学系统传输的光;以及控制单元。 光学系统包括设置在样品和二维阵列光检测器之间的第一光学装置，设置在二维阵列光检测器和第一光学装置之间的第二光学装置，以及设置在二维阵列光检测器中的可变带通滤光器 第一光学装置和样品之间以及第二光学装置与二维阵列光检测器之间的空间中的至少一个。 控制单元根据二维阵列光检测器的拍摄定时改变可变带通滤波器的光透射波长带。