公开(公告)号：US08426824B2

公开(公告)日：2013-04-23

申请号：US12935254

申请日：2009-03-30

Applicant: Yves Jongen ,  Martin Arnold ,  Yves Claereboudt ,  Damien Prieels

Inventor： Yves Jongen ,  Martin Arnold ,  Yves Claereboudt ,  Damien Prieels

IPC: G01T1/24

CPC classification number: G01T1/2935

Abstract: The present invention relates to a detector for measuring characteristics of an energetic particle beam generated by a radiation source, the detector including means to vary the incoming particle beam energy; a plurality of sensors arranged in parallel; and processing means capable of processing signals coming from said sensors in correlation with said energy variation.

Abstract translation: 本发明涉及一种用于测量由辐射源产生的能量粒子束的特性的检测器，该检测器包括改变进入的粒子束能量的装置; 多个并联布置的传感器; 以及能够处理与所述能量变化相关的来自所述传感器的信号的处理装置。

公开(公告)号：US20130001432A1

公开(公告)日：2013-01-03

申请号：US13498131

申请日：2012-03-23

Applicant: Yves Jongen

Inventor： Yves Jongen

IPC: H01J3/14

CPC classification number: H01J3/26 ,  A61N5/01 ,  A61N5/10 ,  A61N5/1077 ,  A61N5/1081 ,  A61N2005/1087 ,  G21K1/093

Abstract: The present invention relates to a particle therapy apparatus used for radiation therapy. More particularly, this invention relates to a compact isocentric gantry for delivering particle beams perpendicularly to a rotation axis of the gantry. The gantry comprises three dipole magnets. The angle of the last dipole magnet is smaller than 90° and a most preferred bending angle for this last dipole magnet is 60°.

Abstract translation: 本发明涉及用于放射治疗的颗粒治疗装置。 更具体地，本发明涉及一种用于沿垂直于台架的旋转轴线输送颗粒束的紧凑型等中心台架。 龙门架包括三个偶极子磁体。 最后的偶极子磁体的角度小于90°，​​最后的偶极子磁体的最佳弯曲角度为60°。

公开(公告)号：US20120228493A1

公开(公告)日：2012-09-13

申请号：US13412734

申请日：2012-03-06

Applicant: Bernard GOTTSCHALK ,  Yves Jongen

Inventor： Bernard GOTTSCHALK ,  Yves Jongen

IPC: G01N23/00

CPC classification number: A61N5/1075 ,  A61N5/103 ,  A61N2005/1087

Abstract: A method for determining a water equivalent depth between an entrance point and a reference point is disclosed. The method may comprise sending to a charged particle beam detector placed at a reference point within or beyond a body a charged particle beam whose energy is modulated between a minimum and maximum energy value, acquiring the time dependent response of said charged particle beam detector, determining from said time dependent response a value of a statistical parameter, providing a calibration curve expressing a relationship between values of said statistical parameter and water equivalent depths, and extracting from this calibration curve the water equivalent depth corresponding to the value of the statistical parameter determined from the time dependent response of the charged particle beam detector placed at the reference point.

Abstract translation: 公开了一种用于确定入口点和参考点之间的水当量深度的方法。 该方法可以包括发送到放置在体内或超过身体的参考点的带电粒子束检测器，其带电粒子束的能量在最小和最大能量值之间调制，获取所述带电粒子束检测器的时间相关响应，确定 从所述时间依赖响应中获取统计参数的值，提供表示所述统计参数的值与水当量深度之间的关系的校准曲线，以及从该校准曲线提取与由下式确定的统计参数的值相对应的水当量深度： 放置在参考点的带电粒子束检测器的时间依赖响应。

公开(公告)号：US20110186720A1

公开(公告)日：2011-08-04

申请号：US13002484

申请日：2009-07-03

Applicant: Yves Jongen ,  Frédéric Stichelbaut

Inventor： Yves Jongen ,  Frédéric Stichelbaut

IPC: G01D18/00 ,  G01T1/164

CPC classification number: G01T1/169 ,  A61B6/4258 ,  A61N5/1048 ,  A61N2005/1052 ,  A61N2005/1087 ,  G01T1/1642

Abstract: The invention is related to the field of charged Hadron Therapy, i.e. radiation therapy using strongly interacting particles. More particularly, the invention relates to a detector and method for measuring the beam range of a charged hadron beam in a target object as well as the particle dose distribution in the target object.

Abstract translation: 本发明涉及充电强子治疗领域，即使用强相互作用的颗粒的放射治疗。 更具体地，本发明涉及一种用于测量目标物体中的带电荷的强子光束的光束范围以及目标物体中的粒子剂量分布的检测器和方法。

公开(公告)号：US07940881B2

公开(公告)日：2011-05-10

申请号：US10537975

申请日：2003-12-10

Applicant: Yves Jongen ,  Jozef Comor

Inventor： Yves Jongen ,  Jozef Comor

IPC: G21G1/12

CPC classification number: G21G1/10

Abstract: The present invention is related to a device and a method for producing a radioisotope of interest from a target fluid irradiated with a beam of accelerated charged particles, the device includes in a circulation circuit (17): an irradiation cell (1) having a metallic insert (2) able to form a cavity (8) designed to house the target fluid and closed by an irradiation window (7), the cavity (8) including at least one inlet (4) and at least one outlet (5); a pump (16) for circulating the target fluid inside the circulation circuit (17); an external heat exchanger (15); the pump (16) and the external heat exchanger (15) forming external cooling means of the target fluid; the device means for pressurizing (14) of the circulation circuit (17) and the external cooling means of the target fluid are arranged in such a way that the target fluid remains inside the cavity (8) essentially in the liquid state during the irradiation.

Abstract translation: 本发明涉及一种用于由照射有加速带电粒子束的目标流体生产感兴趣的放射性同位素的装置和方法，该装置包括在循环回路（17）中：具有金属 插入件（2），其能够形成设计成容纳目标流体并被辐照窗（7）封闭的空腔（8），空腔（8）包括至少一个入口（4）和至少一个出口（5）; 用于使目标流体循环在循环回路（17）内的泵（16）; 外部热交换器（15）; 所述泵（16）和所述外部热交换器（15）形成所述目标流体的外部冷却装置; 用于对循环回路（17）进行加压（14）的装置和目标流体的外部冷却装置以使得目标流体在照射期间基本上保持在液体状态的空腔（8）内的方式被布置。

公开(公告)号：US09451688B2

公开(公告)日：2016-09-20

申请号：US13380446

申请日：2010-06-24

Applicant: Yves Jongen

Inventor： Yves Jongen

IPC: H05H7/08 ,  H05H7/00 ,  A61N5/10

CPC classification number: H05H7/00 ,  A61N5/1048 ,  A61N5/1067 ,  A61N2005/1087

Abstract: The present invention relates to a pulsed beam particle accelerator which can be used for particle radiation therapy. More particular, a device and method are provided to control the number of particles within a beam pulse. The particle accelerator comprises means for varying the number of particles within each beam pulse of said pulsed ion beam from a minimum value to a maximum value as function of the value of a beam control parameter. For each particle irradiation the required number of particles for each beam pulse is controlled by defining a value for said beam control parameter based on calibration data.

Abstract translation: 本发明涉及可用于粒子辐射治疗的脉冲束粒子加速器。 更具体地，提供了一种装置和方法来控制光束脉冲内的粒子数量。 粒子加速器包括用于将所述脉冲离子束的每个束脉冲内的粒子数量从最小值改变为最大值的装置，作为束控制参数的值的函数。 对于每个粒子照射，通过基于校准数据定义所述光束控制参数的值来控制每个光束脉冲的所需数量的粒子。

公开(公告)号：US08508158B2

公开(公告)日：2013-08-13

申请号：US13408069

申请日：2012-02-29

Applicant: Marshall R. Cleland ,  Richard A. Galloway ,  Leonard DeSanto ,  Yves Jongen

Inventor： Marshall R. Cleland ,  Richard A. Galloway ,  Leonard DeSanto ,  Yves Jongen

IPC: H05H7/00

CPC classification number: H05H15/00 ,  H05H5/00 ,  H05H5/02

Abstract: A dc accelerator system able to accelerate high currents of proton beams at high energies is provided. The accelerator system includes a dc high-voltage, high-current power supply, an evacuated ion accelerating tube, a proton ion source, a dipole analyzing magnet and a vacuum pump located in the high-voltage terminal. The high-current, high-energy dc proton beam can be directed to a number of targets depending on the applications such as boron neutron capture therapy BNCT applications, NRA applications, and silicon cleaving.

Abstract translation: 提供了能够以高能量加速质子束高电流的直流加速器系统。 加速器系统包括位于高压端子中的直流高压，大电流电源，抽真空离子加速管，质子离子源，偶极子分析磁体和真空泵。 高电流，高能量直流质子束可以根据诸如硼中子俘获治疗BNCT应用，NRA应用和硅裂解的应用而被引导到多个靶。

公开(公告)号：US20120280150A1

公开(公告)日：2012-11-08

申请号：US13502946

申请日：2012-04-19

Applicant: Yves Jongen

Inventor： Yves Jongen

IPC: A61N5/10

CPC classification number: A61N5/10 ,  A61N5/1081 ,  A61N2005/1087 ,  G21K1/093 ,  G21K5/04

Abstract: The present invention relates to a particle therapy apparatus used for radiation therapy. More particularly, this invention relates to a gantry for delivering particle beams which comprises means to analyse the incoming beam. Means are integrated into the gantry to limit the momentum spread of the beam and/or the emittance of the beam.

Abstract translation: 本发明涉及用于放射治疗的颗粒治疗装置。 更具体地说，本发明涉及一种用于传送粒子束的台架，其包括分析入射光束的装置。 装置被集成到台架中以限制梁的动量扩展和/或束的发射。

公开(公告)号：US20120161672A1

公开(公告)日：2012-06-28

申请号：US13408069

申请日：2012-02-29

Applicant: Marshall R. Cleland ,  Richard A. Galloway ,  Leonard DeSanto ,  Yves Jongen

Inventor： Marshall R. Cleland ,  Richard A. Galloway ,  Leonard DeSanto ,  Yves Jongen

IPC: H05H13/00

CPC classification number: H05H15/00 ,  H05H5/00 ,  H05H5/02

Abstract: A dc accelerator system able to accelerate high currents of proton beams at high energies is provided. The accelerator system includes a dc high-voltage, high-current power supply, an evacuated ion accelerating tube, a proton ion source, a dipole analyzing magnet and a vacuum pump located in the high-voltage terminal. The high-current, high-energy dc proton beam can be directed to a number of targets depending on the applications such as boron neutron capture therapy BNCT applications, NRA applications, and silicon cleaving.

Abstract translation: 提供了能够以高能量加速质子束高电流的直流加速器系统。 加速器系统包括位于高压端子中的直流高压，大电流电源，抽真空离子加速管，质子离子源，偶极子分析磁体和真空泵。 高电流，高能量直流质子束可以根据诸如硼中子俘获治疗BNCT应用，NRA应用和硅裂解的应用而被引导到多个靶。

公开(公告)号：US20100033115A1

公开(公告)日：2010-02-11

申请号：US12539347

申请日：2009-08-11

Applicant: Marshall R. Cleland ,  Richard A. Galloway ,  Leonard DeSanto ,  Yves Jongen

Inventor： Marshall R. Cleland ,  Richard A. Galloway ,  Leonard DeSanto ,  Yves Jongen

IPC: H05H7/00

CPC classification number: H05H15/00 ,  H05H5/00 ,  H05H5/02

Abstract: A dc accelerator system able to accelerate high currents of proton beams at high energies is provided. The accelerator system includes a dc high-voltage, high-current power supply, an evacuated ion accelerating tube, a proton ion source, a dipole analyzing magnet and a vacuum pump located in the high-voltage terminal. The high-current, high-energy dc proton beam can be directed to a number of targets depending on the applications such as boron neutron capture therapy BNCT applications, NRA applications, and silicon cleaving.

Abstract translation: 提供了能够以高能量加速质子束高电流的直流加速器系统。 加速器系统包括位于高压端子中的直流高压，大电流电源，抽真空离子加速管，质子离子源，偶极子分析磁体和真空泵。 高电流，高能量直流质子束可以根据诸如硼中子俘获治疗BNCT应用，NRA应用和硅裂解的应用而被引导到多个靶。