公开(公告)号：US20170245766A1

公开(公告)日：2017-08-31

申请号：US15433502

申请日：2017-02-15

Applicant: Novadaq Technologies Inc.

Inventor： Robert W. FLOWER ,  Robert Anthony STEAD ,  Arthur E. BAILEY

IPC: A61B5/026 ,  A61B5/024 ,  A61B5/00

CPC classification number: A61B5/0261 ,  A61B5/0071 ,  A61B5/02416 ,  A61B5/0275 ,  A61B5/029 ,  A61B5/6826

Abstract: Methods and systems for facilitating assessment of blood flow in a tissue volume of a subject are disclosed. In some variations, the method may include: after a predetermined amount of a fluorescence agent has been administered to the subject, exciting the fluorescence agent in the tissue volume such that the excited fluorescence agent emits fluorescent light, acquiring fluorescence data based on the fluorescent light emitted during blood flow through the tissue volume, estimating a molar concentration of the fluorescence agent in the blood flowing through the tissue volume, and generating an assessment of blood flow in the tissue volume based at least in part on the fluorescence data and the estimated molar concentration of the fluorescence agent. The estimated molar concentration may be based on the predetermined amount of the fluorescence agent and an estimated circulating blood volume of the subject.

公开(公告)号：US20170124768A1

公开(公告)日：2017-05-04

申请号：US15337986

申请日：2016-10-28

Applicant: Novadaq Technologies Inc.

Inventor： Jorgen WALLE-JENSEN ,  Lina GUREVICH ,  Gregory Vincent BROWNE

IPC: G06T19/00 ,  A61K49/00 ,  G06T7/33

CPC classification number: G06T19/006 ,  A61B5/0071 ,  A61K49/0034 ,  G06T7/33 ,  G06T2207/10016 ,  G06T2207/10064 ,  G06T2207/30048 ,  G06T2207/30104 ,  G06T2207/30196 ,  G06T2207/30204 ,  G06T2210/41

Abstract: Methods and systems for alignment of a subject for medical imaging are disclosed, and involve providing a reference image of an anatomical region of the subject, the anatomical region comprising a target tissue, processing the reference image to generate an alignment reference image, displaying the alignment reference image concurrently with real-time video of the anatomical region, and aligning the real-time video with the alignment reference image to overlay the real-time video with the alignment reference image. Following such alignment, the subject may be imaged using, for example, fluorescence imaging, wherein the fluorescence imaging may be performed by an image acquisition assembly aligned in accordance with the alignment.

公开(公告)号：US08498695B2

公开(公告)日：2013-07-30

申请号：US11964330

申请日：2007-12-26

Applicant: Paul Westwick ,  David Potkins ,  John Fengler

Inventor： Paul Westwick ,  David Potkins ,  John Fengler

IPC: A61B6/00

CPC classification number: H04N7/183 ,  A61B1/041 ,  A61B1/043 ,  A61B1/045 ,  A61B1/051 ,  A61B1/0638 ,  A61B1/0646 ,  A61B1/0669 ,  A61B1/0676 ,  A61B1/0684 ,  A61B1/128 ,  A61B3/18 ,  H04N5/2256 ,  H04N9/045 ,  H04N2005/2255

Abstract: An endoscopic video system and method using a camera with a single color image sensor, for example a CCD color image sensor, for fluorescence and color imaging and for simultaneously displaying the images acquired in these imaging modes at video rates in real time is disclosed. The tissue under investigation is illuminated continuously with fluorescence excitation light and is further illuminated periodically using visible light outside of the fluorescence excitation wavelength range. The illumination sources may be conventional lamps using filters and shutters, or may include light-emitting diodes mounted at the distal tip of the endoscope.

公开(公告)号：US08406860B2

公开(公告)日：2013-03-26

申请号：US12841659

申请日：2010-07-22

Applicant: Peter Dvorsky ,  David Mark Henri Goyette ,  T. Bruce Ferguson, Jr. ,  Cheng Chen

Inventor： Peter Dvorsky ,  David Mark Henri Goyette ,  T. Bruce Ferguson, Jr. ,  Cheng Chen

IPC: A61B6/00 ,  A61B5/00

CPC classification number: A61B5/0275 ,  A61B5/0059 ,  A61B5/0261 ,  A61B5/489 ,  A61B5/7225 ,  A61B6/503 ,  A61B6/504 ,  A61B6/507 ,  A61B2576/02 ,  A61M5/007 ,  G06T7/0012 ,  G06T7/12 ,  G06T7/248 ,  G06T7/90 ,  G06T2207/10064 ,  G06T2207/30104

Abstract: Vessel perfusion and myocardial blush are determined by analyzing fluorescence signals obtained in a static region-of-interest (ROI) in a collection of fluorescence images of myocardial tissue. The blush value is determined from the total intensity of the intensity values of image elements located within the smallest contiguous range of image intensity values containing a predefined fraction of a total measured image intensity of all image elements within the ROI. Vessel (arterial) peak intensity is determined from image elements located within the ROI that have the smallest contiguous range of highest measured image intensity values and contain a predefined fraction of a total measured image intensity of all image elements within the ROI. Cardiac function can be established by comparing the time differential between the time of peak intensity in a blood vessel and that in a region of neighboring myocardial tissue both pre and post procedure.

公开(公告)号：US07918559B2

公开(公告)日：2011-04-05

申请号：US11912944

申请日：2006-05-01

Applicant: John C. Tesar

Inventor： John C. Tesar

IPC: A61B3/10 ,  A61B3/00

CPC classification number: A61B3/12

Abstract: The invention provides an apparatus, a device, and methods for imaging vasculature in a subject as well as an apparatus, a device and methods for treating abnormal vasculature in a subject.

Abstract translation: 本发明提供了一种用于在受试者中成像脉管系统的装置，装置和方法，以及用于治疗受试者的异常脉管系统的装置，装置和方法。

公开(公告)号：US20100210904A1

公开(公告)日：2010-08-19

申请号：US12761462

申请日：2010-04-16

Applicant: Richard W. Cline ,  John J.P. Fengler ,  Joachim W. Boehm

Inventor： Richard W. Cline ,  John J.P. Fengler ,  Joachim W. Boehm

IPC: A61B1/04

CPC classification number: A61B5/0071 ,  A61B1/00009 ,  A61B1/00057 ,  A61B1/00186 ,  A61B1/041 ,  A61B1/043 ,  A61B1/045 ,  A61B1/051 ,  A61B1/06 ,  A61B1/063 ,  A61B1/0638 ,  A61B1/0646 ,  A61B1/0669 ,  A61B1/2676 ,  A61B5/0084 ,  G01N21/6458 ,  G06F19/00

Abstract: A fluorescence endoscopy video system includes a multimode light source that produces light for color and fluorescence imaging modes. Light from the light source is transmitted through an endoscope to the tissue under observation. The system also includes a compact camera for color and fluorescence imaging. Images obtained through the endoscope are optically divided and projected onto one or more image sensors by a fixed beam splitter in the camera. The fixed beam splitter eliminates the need for inserting a movable mirror into the light path between the endoscope and the image sensors. Image signals from the camera are processed in the system processor/controller where a contrast enhancement function can be applied. The contrast enhancement function increases the color contrast between normal tissue and tissue suspicious for early cancer. Finally, the system also includes a calibration feature whereby the system performance can be maintained when used with different endoscopes.

Abstract translation: 荧光内窥镜视频系统包括产生用于彩色和荧光成像模式的光的多模光源。 来自光源的光通过内窥镜透射到观察的组织。 该系统还包括一个用于彩色和荧光成像的小型相机。 通过内窥镜获得的图像通过照相机中的固定分束器被光学分割并投影到一个或多个图像传感器上。 固定分束器不需要将可移动反射镜插入到内窥镜和图像传感器之间的光路中。 来自相机的图像信号在可应用对比度增强功能的系统处理器/控制器中进行处理。 对比度增强功能增加了早期癌症可疑的正常组织和组织之间的颜色对比。 最后，该系统还包括校准特征，从而当与不同的内窥镜一起使用时可以维持系统性能。

公开(公告)号：US20100198010A1

公开(公告)日：2010-08-05

申请号：US12761523

申请日：2010-04-16

Applicant: Richard W. Cline ,  John J.P. Fengler ,  Joachim W. Boehm

Inventor： Richard W. Cline ,  John J.P. Fengler ,  Joachim W. Boehm

IPC: A61B1/04

CPC classification number: A61B5/0071 ,  A61B1/00009 ,  A61B1/00057 ,  A61B1/00186 ,  A61B1/041 ,  A61B1/043 ,  A61B1/045 ,  A61B1/051 ,  A61B1/06 ,  A61B1/063 ,  A61B1/0638 ,  A61B1/0646 ,  A61B1/0669 ,  A61B1/2676 ,  A61B5/0084 ,  G01N21/6458 ,  G06F19/00 ,  G16Z99/00

Abstract: A fluorescence endoscopy video system includes a multimode light source that produces light for color and fluorescence imaging modes. Light from the light source is transmitted through an endoscope to the tissue under observation. The system also includes a compact camera for color and fluorescence imaging. Images obtained through the endoscope are optically divided and projected onto one or more image sensors by a fixed beam splitter in the camera. The fixed beam splitter eliminates the need for inserting a movable mirror into the light path between the endoscope and the image sensors. Image signals from the camera are processed in the system processor/controller where a contrast enhancement function can be applied. The contrast enhancement function increases the color contrast between normal tissue and tissue suspicious for early cancer. Finally, the system also includes a calibration feature whereby the system performance can be maintained when used with different endoscopes.

公开(公告)号：US20090303317A1

公开(公告)日：2009-12-10

申请号：US12278740

申请日：2007-02-07

Applicant: John C. Tesar

Inventor： John C. Tesar

IPC: H04N7/18

CPC classification number: A61B5/0075 ,  A61B1/0661 ,  A61B1/07 ,  C03C17/3417 ,  C03C17/3452 ,  G02B5/04 ,  G02B23/2453 ,  G02B27/1013 ,  G02B27/142 ,  G02B27/145 ,  H04N5/2256 ,  H04N5/33 ,  H04N2005/2255

Abstract: An endoscope or wand device comprising transmitting members, in which the transmitting members comprise a coating that transmits between about 95% and about 99.5% of energy at a wavelength within the infra red spectrum.

Abstract translation: 一种内窥镜或棒装置，包括透射构件，其中透射构件包括在红外光谱内的波长处透射约95％至约99.5％的能量的涂层。

公开(公告)号：US20080239070A1

公开(公告)日：2008-10-02

申请号：US11964330

申请日：2007-12-26

Applicant: Paul Westwick ,  David Potkins ,  John Fengler

Inventor： Paul Westwick ,  David Potkins ,  John Fengler

IPC: H04N7/18

CPC classification number: H04N7/183 ,  A61B1/041 ,  A61B1/043 ,  A61B1/045 ,  A61B1/051 ,  A61B1/0638 ,  A61B1/0646 ,  A61B1/0669 ,  A61B1/0676 ,  A61B1/0684 ,  A61B1/128 ,  A61B3/18 ,  H04N5/2256 ,  H04N9/045 ,  H04N2005/2255

Abstract: An endoscopic video system and method using a camera with a single color image sensor, for example a CCD color image sensor, for fluorescence and color imaging and for simultaneously displaying the images acquired in these imaging modes at video rates in real time is disclosed. The tissue under investigation is illuminated continuously with fluorescence excitation light and is further illuminated periodically using visible light outside of the fluorescence excitation wavelength range. The illumination sources may be conventional lamps using filters and shutters, or may include light-emitting diodes mounted at the distal tip of the endoscope.

Abstract translation: 公开了一种使用具有用于荧光和彩色成像的单色彩色图像传感器（例如CCD彩色图像传感器）的相机和用于以视频速率实时显示在这些成像模式中获取的图像的内窥镜视频系统和方法。 用荧光激发光连续照射被研究的组织，并使用荧光激发波长范围外的可见光进一步周期性地照射。 照明源可以是使用过滤器和百叶窗的常规灯，或者可以包括安装在内窥镜的远端的发光二极管。

公开(公告)号：US07341557B2

公开(公告)日：2008-03-11

申请号：US10899648

申请日：2004-07-26

Applicant: Richard W. Cline ,  John J. P. Fengler ,  Joachim W. Boehm

Inventor： Richard W. Cline ,  John J. P. Fengler ,  Joachim W. Boehm

IPC: A61B1/04

CPC classification number: A61B5/0071 ,  A61B1/00009 ,  A61B1/00057 ,  A61B1/00186 ,  A61B1/041 ,  A61B1/043 ,  A61B1/045 ,  A61B1/051 ,  A61B1/06 ,  A61B1/063 ,  A61B1/0638 ,  A61B1/0646 ,  A61B1/0669 ,  A61B1/2676 ,  A61B5/0084 ,  G01N21/6458 ,  G06F19/00

Abstract: A fluorescence endoscopy video system includes a multimode light source that produces light for color and fluorescence imaging modes. Light from the light source is transmitted through an endoscope to the tissue under observation. The system also includes a compact camera for color and fluorescence imaging. Images obtained through the endoscope are optically divided and projected onto one or more image sensors by a fixed beam splitter in the camera. The fixed beam splitter eliminates the need for inserting a movable mirror into the light path between the endoscope and the image sensors. Image signals from the camera are processed in the system processor/controller where a contrast enhancement function can be applied. The contrast enhancement function increases the color contrast between normal tissue and tissue suspicious for early cancer. Finally, the system also includes a calibration feature whereby the system performance can be maintained when used with different endoscopes.

Abstract translation: 荧光内窥镜视频系统包括产生用于彩色和荧光成像模式的光的多模光源。 来自光源的光通过内窥镜透射到观察的组织。 该系统还包括一个用于彩色和荧光成像的小型相机。 通过内窥镜获得的图像通过照相机中的固定分束器被光学分割并投影到一个或多个图像传感器上。 固定分束器不需要将可移动反射镜插入到内窥镜和图像传感器之间的光路中。 来自相机的图像信号在可应用对比度增强功能的系统处理器/控制器中进行处理。 对比度增强功能增加了早期癌症可疑的正常组织和组织之间的颜色对比。 最后，该系统还包括校准特征，从而当与不同的内窥镜一起使用时可以维持系统性能。