公开(公告)号：US11458235B2

公开(公告)日：2022-10-04

申请号：US16466138

申请日：2017-12-05

Applicant: TEMASEK POLYTECHNIC ,  AWAK TECHNOLOGIES PTE LTD

Inventor： Christian Gert Bluchel ,  Peter Haywood

IPC: A61M1/16 ,  B01J39/17 ,  B01J20/02 ,  B01J20/24 ,  B01J47/02 ,  B01J47/04 ,  B01J20/20 ,  B01J39/12 ,  B01J41/10 ,  B01D15/08 ,  B01J47/024

Abstract: The invention relates to a sorbent for removing metabolic waste products from a dialysis liquid, the sorbent comprising a soluble source of sodium ions. The sorbent comprises an ion exchange system which converts urea to ammonium ions and which is configured to exchange ammonium ions for predominantly hydrogen ions and to exchange Ca, Mg, and K for predominantly sodium ions. The soluble source of sodium ions overcomes an initial drop in sodium concentration in regenerated dialysate. When used in conjunction with an infusion system configured to utilise exchange of Ca, Mg and K for sodium during dialysate regeneration a desired sodium ion concentration can be maintained.

公开(公告)号：US20140309584A1

公开(公告)日：2014-10-16

申请号：US13885273

申请日：2011-11-08

Applicant: Christian Gert Bluchel ,  Liutong Lin

Inventor： Christian Gert Bluchel ,  Liutong Lin

IPC: A61M1/28

CPC classification number: A61M1/28 ,  A61M1/1658 ,  A61M1/1696 ,  A61M2205/121 ,  A61M2205/123 ,  A61M2205/126 ,  A61M2205/128 ,  A61M2205/33 ,  A61M2205/7518 ,  A61M2209/088

Abstract: A dialysis device is provided comprising a disposable housing having a dialysate flow path along which dialysate received from a patient is subjected to contaminant removal when in operation, wherein said disposable housing comprises a storage chamber in fluid communication with the dialysate flow path for storing the dialysate therein; a controller for controlling the operation of said disposable housing; an interface means capable of operably coupling the controller and the disposable housing to enable the contaminant removal from the dialysate, and a fluid displacement means configured to move the dialysate along the dialysate flow path, wherein said fluid displacement means comprises a deformable diaphragm integrally formed with at least one wall of said storage chamber, wherein the flow path is fluidly sealed from the controller and interface means. A method of dialysis, a dialysis system and kits are also provided.

Abstract translation: 提供了一种透析装置，其包括具有透析液流动通道的一次性外壳，沿着该透析液流路从患者接收的透析液在操作时经受污染物去除，其中所述一次性外壳包括与用于储存透析液的透析液流动路径流体连通的储存室 其中 用于控制所述一次性外壳的操作的控制器; 接口装置，其能够可操作地联接所述控制器和所述一次性外壳以使得能够从所述透析液中除去污染物;以及流体移动装置，其被配置为沿所述透析液流动路径移动所述透析液，其中所述流体移动装置包括可变形隔膜， 所述储存室的至少一个壁，其中所述流动路径与所述控制器和接口装置流体密封。 还提供透析方法，透析系统和试剂盒。

公开(公告)号：US08440441B2

公开(公告)日：2013-05-14

申请号：US13580055

申请日：2011-02-18

Applicant: Christian Bluchel ,  Yanmei Wang

Inventor： Christian Bluchel ,  Yanmei Wang

IPC: C12N11/02 ,  C02F1/00

CPC classification number: C12N11/12 ,  B01D61/243 ,  B01D67/0093 ,  B01D71/16 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3248 ,  B01J20/3251 ,  C12N11/06 ,  G01N33/54353

Abstract: A substrate having compounds disposed thereon for immobilizing a functional molecule, each compound having a chain comprising: a moiety R that is chemically coupled to the substrate, said moiety R being selected from the group consisting of an ether, ester, carbonyl, carbonate ester, thioether, disulfide, sulfinyl, sulfonyl, and carbonothioyl; and an epoxide-containing moiety that is coupled to the moiety R by a linker comprising at least one nucleophilic group. Methods of preparing the substrate and use of the substrate are also disclosed.

Abstract translation: 一种底物，其上设置有用于固定功能性分子的化合物，每种化合物具有包括：与基底化学偶联的部分R，所述部分R选自醚，酯，羰基，碳酸酯， 硫醚，二硫化物，亚磺酰基，磺酰基和碳硫酰基; 和通过包含至少一个亲核基团的连接体与部分R偶联的含环氧化物的部分。 还公开了制备基材和使用基材的方法。

公开(公告)号：US20240058514A1

公开(公告)日：2024-02-22

申请号：US17918818

申请日：2021-04-13

Applicant: TEMASEK POLYTECHNIC

Inventor： Christian Gert BLUECHEL ,  Cathy Padua SAGUN ,  Puay Meng TANG ,  Liutong LIN, I ,  Hua ZHANG ,  Keng Hong LEE

IPC: A61M1/16 ,  A61M1/14 ,  A61M1/26 ,  B01D15/16 ,  B01D15/18 ,  B01D15/36 ,  B01J39/02 ,  B01J39/10 ,  B01J47/018 ,  B01J47/12

CPC classification number: A61M1/1696 ,  A61M1/1563 ,  A61M1/1605 ,  A61M1/267 ,  B01D15/166 ,  B01D15/18 ,  B01D15/362 ,  B01D15/363 ,  B01J39/02 ,  B01J39/10 ,  B01J47/018 ,  B01J47/12 ,  A61M2205/3331

Abstract: An aspect of the disclosure relates to a dialysate regenerator, including: a purification means; at least one reversible retainer including an ion reservoir; a dialysate flow path including a dialysate inlet for receiving a dialysate, a dialysate outlet for dispensing the dialysate, the purification means and the at least one reversible retainer: a pump connected to the dialysate flow path and configured to generate a flow of the dialysate from the dialysate inlet via the reversible retainer and the purification means to the dialysate outlet, wherein a direction of the dialysate flow path through the reversible retainer is reversible.

公开(公告)号：US11600830B2

公开(公告)日：2023-03-07

申请号：US17005481

申请日：2020-08-28

Applicant: Temasek Polytechnic

Inventor： Ming Han ,  Yunzhong Chen ,  Lei Wang ,  Chun Yu Ling

IPC: H01M8/0254 ,  H01M8/0258 ,  H01M8/1004

Abstract: A plate member for a cell stack, a cell stack assembly, a method of forming a plate member for a cell stack and a method of assembling a cell stack may be provided, and the plate member includes a channel sheet with at least one peak and one trough for forming fluid flow channels; two alignment parts, each alignment part including a main body and one or more alignment members or holes, the main body having a through hole provided within the main body; and wherein the alignment part is capable of aligning the channel sheet parallel to a plane of the main body and the alignment member is capable of aligning the alignment member to another corresponding alignment member along an axis passing through the alignment member; and further wherein the channel sheet is disposed between the two alignment parts.

公开(公告)号：US11590272B2

公开(公告)日：2023-02-28

申请号：US16792774

申请日：2020-02-17

Applicant: TEMASEK POLYTECHNIC

Inventor： Christian Gert Bluchel ,  Yanmei Wang ,  Kim Cheng Tan

IPC: A61M1/36 ,  A61M1/28 ,  B01J20/06 ,  B01J20/20 ,  B01J20/22 ,  B01J20/28 ,  B01J39/12 ,  B01J41/10 ,  A61M1/16 ,  B01D15/20 ,  B01D15/36

Abstract: There is provided a sorbent for removing metabolic waste products from a dialysis liquid, the sorbent comprising a layer of immobilized uremic toxin-treating enzyme particles intermixed with cation exchange particles.

公开(公告)号：US11186482B2

公开(公告)日：2021-11-30

申请号：US16430142

申请日：2019-06-03

Applicant: TEMASEK POLYTECHNIC

Inventor： Lei Wang ,  Ming Han ,  Yunzhong Chen ,  Ee Ho Gareth Tang

IPC: C01B3/06 ,  B01J7/02 ,  B01J21/18 ,  B01J23/42 ,  B01J31/06 ,  C01B3/00 ,  H01M8/065 ,  H01M8/1018

Abstract: The present invention relates to a solid fuel, a system and a method for generating hydrogen. The solid fuel comprises sodium borohydride, catalyst loaded fibres and a binder, wherein the catalyst loaded fibres and the binder form a scaffold structure within which the sodium borohydride is positioned. The system comprises a fuel cartridge containing the solid fuel of the present invention for generating hydrogen gas, a reactor configured to house the fuel cartridge, a tank for storing water, a pump and a liquid conduit for conveying water from the tank to the fuel cartridge housed within the reactor to induce a hydrolysis reaction of the solid fuel contained in the fuel cartridge and a controller for regulating flow of the water.

公开(公告)号：US20210205522A1

公开(公告)日：2021-07-08

申请号：US17209439

申请日：2021-03-23

Applicant: TEMASEK POLYTECHNIC

Inventor： Christian Gert Bluchel ,  Liutong Lin

IPC: A61M1/28 ,  A61M1/16

Abstract: A dialysis device is provided including a disposable housing having a flow path along which dialysate received from a patient is subjected to contaminant removal when in operation. The device includes a controller for controlling the operation of the disposable housing and an interface capable of operably coupling the controller and the disposable housing to enable the contaminant removal from the dialysate. The flow path is fluidly sealed from the controller and interface.

公开(公告)号：US10763518B2

公开(公告)日：2020-09-01

申请号：US15571845

申请日：2016-04-29

Applicant: TEMASEK POLYTECHNIC

Inventor： Ming Han ,  Yunzhong Chen ,  Lei Wang ,  Chun Yu Ling

IPC: H01M8/0254 ,  H01M8/0258 ,  H01M8/248 ,  H01M8/2483 ,  H01M8/2465 ,  H01M8/1018

Abstract: A plate member for a cell stack, a cell stack assembly, a method of forming a plate member for a cell stack and a method of assembling a cell stack may be provided, and the plate member comprises a channel sheet comprising at least one peak and one trough for forming fluid flow channels; two alignment parts, each alignment part comprising a main body and one or more alignment members, the main body having a through hole provided within the main body; and wherein the alignment part is capable of aligning the channel sheet parallel to a plane of the main body and the alignment member is capable of aligning the alignment member to another corresponding alignment member along an axis passing through the alignment member; and further wherein the channel sheet is disposed between the two alignment parts.

公开(公告)号：US20190302022A1

公开(公告)日：2019-10-03

申请号：US16318946

申请日：2017-07-21

Applicant: Temasek Polytechnic ,  Agency for Science, Technology and Research ,  Tan Tock Seng Hospital Pte Ltd

Inventor： Ling Ling Sun ,  Willie Ng ,  Xiaodong Zhou ,  Ten It Wong ,  Yee Sin Leo

IPC: G01N21/552 ,  G01N21/01 ,  G01N33/74

Abstract: Disclosed is a localised surface plasmon resonance (LSPR) nanopillar assembly. The LSPR assembly is for use in sensing the presence of a biomarker when attached to a quantum dot. The LSPR assembly comprises a substrate and an array. The array comprises a LSPR nanopillar and a polymer spacer attached to the nanopillar. The LSPR assembly further comprises an antibody attached to the at least one polymer spacer. In the LSPR assembly, a combined height of the polymer spacer and antibody is selected by varying the number of monomer units of the polymer spacer, so that, when in use with the biomarker and the quantum dot, the quantum dot is at a predetermined distance from the nanopillar.