公开(公告)号：US12173046B2

公开(公告)日：2024-12-24

申请号：US18619759

申请日：2024-03-28

Applicant: Universitat Stuttgart

Inventor： Roman Fischer ,  Martin Siegemund ,  Klaus Pfizenmaier ,  Roland Kontermann

IPC: C07K14/525 ,  A61K38/19 ,  C07K14/705 ,  C07K19/00 ,  A61K38/00

Abstract: The present invention relates to polypeptide consisting of three TNF homology domains of TNF-ligand family members proteins (THD) that specifically bind to the extracellular part of TNFR2, wherein C-terminal and N-terminal reference points are defined by consensus sequences. The THIDs are linked by short stretches of further C-terminal and/or N-terminal amino acids of the THD or variants thereof as well as by peptide linkers. These peptides have an improved stability. Furthermore the invention relates to polypeptide multimers comprising several of the polypeptides of the present invention.

公开(公告)号：US11526331B2

公开(公告)日：2022-12-13

申请号：US16760290

申请日：2017-10-30

Applicant: UNIVERSITAT STUTTGART ,  MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.

Inventor： Tobias Steinle ,  Ilja Gerhardt ,  Johannes Nikolaus Greiner ,  Harald Giessen

IPC: G06F7/58 ,  G02F1/39 ,  H01S3/108

Abstract: An apparatus and a corresponding method for generating at least one random number are disclosed. The apparatus includes an optical parametric oscillator being pumped by a pump signal with a predetermined pump power and a predetermined pump frequency. The optical parametric oscillator is configured to operate in a period multiplication state for providing an oscillator output signal of alternating light pulses, the oscillator output signal having a period that is N-times the period of the pump signal, where N is an integer and N>I. The apparatus also includes a comparing unit being configured to compare the output signal with a reference signal, wherein the reference signal has a frequency that is 1/N of the predetermined pump frequency, and an evaluation unit being configured to generate the at least one random number based on the comparison of the output signal with the reference signal.

公开(公告)号：US07941058B2

公开(公告)日：2011-05-10

申请号：US11568440

申请日：2005-04-28

Applicant: Michael Ohm ,  Timo Pfau

Inventor： Michael Ohm ,  Timo Pfau

IPC: H04B10/00

CPC classification number: H04B10/69 ,  H04B10/677 ,  H04L27/223

Abstract: The invention refers to a device (1) for decoding an optical multi-level DPSK signal (E), the device (1) comprising: means for receiving the multi-level DPSK signal (E); at least two means (3) for transforming optical multi-level DPSK signals (E) into corresponding analog electrical signals (i); means (2) for splitting up the received multi-level DPSK signal (E) into at least two optical multi-level DPSK signals (E0), one for each of the opto-electrical transforming means (3); means (8) for processing electrical signals (i, e); and at least two means (6) for transforming the analog electrical signals (i) into corresponding electrical logical binary signals (e). In order to provide multi-level DPSK receiver (1) with a reduced complexity, it is suggested that concerning the signal flow within the device (1) the analog-to-logical-binary transformation means (6) are disposed before the processing means (8) and that the processing means (8) process electrical logical binary signals (e).

Abstract translation: 本发明涉及用于对光学多电平DPSK信号（E）进行解码的装置（1），该装置（1）包括：用于接收多电平DPSK信号（E）的装置; 用于将光学多电平DPSK信号（E）变换成对应的模拟电信号（i）的至少两个装置（3）; 用于将所接收的多电平DPSK信号（E）分解为至少两个光学多电平DPSK信号（E0）的装置（2），每个光电变换装置（3）一个; 用于处理电信号（i，e）的装置（8）; 以及用于将模拟电信号（i）变换成对应的电逻辑二进制信号（e）的至少两个装置（6）。 为了提供具有降低的复杂度的多电平DPSK接收机（1），建议关于装置（1）内的信号流，将模拟到逻辑二进制变换装置（6）设置在处理装置 （8），并且处理装置（8）处理电逻辑二进制信号（e）。

公开(公告)号：US07710336B2

公开(公告)日：2010-05-04

申请号：US12091622

申请日：2006-09-15

Applicant: Heinz Schweizer ,  Hedwig Graebeldinger ,  Manfred Berroth ,  Harald Giessen ,  Axel Rumberg ,  Liwei Fu

Inventor： Heinz Schweizer ,  Hedwig Graebeldinger ,  Manfred Berroth ,  Harald Giessen ,  Axel Rumberg ,  Liwei Fu

IPC: H01Q19/06

CPC classification number: H01Q19/06 ,  G02B1/007 ,  G02B6/122 ,  H01L2924/0002 ,  H01L2924/00

Abstract: A metamaterial having a negative refractive index is presented, which has a dielectric carrier material (12; 48), first electrically conductive sections (14.1, 14.2, 14.3, 14.4) and second electrically conductive sections (16.1, 16.2). The metamaterial is distinguished by the fact that the dielectric carrier material (12; 48) is realized as a volume which consists of one piece and which has at least one inner area which is prestructured by positive or negative rib or mesa structures (52.1, 52.2) in the dielectric carrier material (48) and is covered with first sections (14.1, 14.2, 14.3, 14.4) and second sections (16.1, 16.2) in such a way that the first sections form capacitive series impedances upon illumination with an electromagnetic wave having a specific propagation direction and polarization, while the second sections are arranged in such a way that they form inductive shunt impedances upon the illumination. An optical element, a preferred use of a metamaterial and also a method for producing a metamaterial are furthermore presented. The structuring of partial regions of the metamaterial can be effected with the aid of negative/positive mesa structures.

Abstract translation: 提供具有负折射率的超材料，其具有介电载体材料（12; 48），第一导电部分（14.1,14.2,14.3,14.4）和第二导电部分（16.1,16.2）。 超材料的特征在于介电载体材料（12; 48）被实现为一体积的体积，该体积由一片构成，并且具有至少一个由正或负肋或台面结构（52.1,52.2）预结构的内部区域 ）并且被第一部分（14.1,14.2,14.3,14.4）和第二部分（16.1,16.2）覆盖，使得第一部分在用电磁波照射时形成电容串联阻抗 具有特定的传播方向和偏振，而第二部分被布置成使得它们在照明时形成感应分流阻抗。 此外，还提出了光学元件，超材料的优选用途以及用于制造超材料的方法。 超材料的部分区域的构造可以借助负/正台面结构来实现。

公开(公告)号：US20090278937A1

公开(公告)日：2009-11-12

申请号：US12386693

申请日：2009-04-22

Applicant: Ralf Botchen ,  Daniel Weiskopf ,  Thomas Ertl ,  Min Chen

Inventor： Ralf Botchen ,  Daniel Weiskopf ,  Thomas Ertl ,  Min Chen

IPC: G06T11/20 ,  H04N5/225

CPC classification number: G06T11/00 ,  G06K9/00771 ,  G06T7/20 ,  G06T2207/10016

Abstract: An embodiment of the present invention relates to systems and methods for dynamically detecting and visualizing actions and/or events in video data streams. In one embodiment, a method involves dynamically detecting and extracting objects and attributes relating to the objects from a video data stream by using action recognition filtering for attribute detection and time series analysis for relation detection among the extracted objects. In addition, the method may involve dynamically generating a multi-field video visualization along a time axis by depicting the video data stream as a series of frames at a relatively sparse or dense interval, and by continuously rendering the attributes relating to the objects with substantially continuous abstract illustrations. Finally, a method may also involve dynamically combining detection, and extraction of objects and combining with multi-field visualization in a video perpetuo gram (VPG), which may show a video stream in parallel, and which allows for real-time display and interaction.

Abstract translation: 本发明的实施例涉及用于动态地检测和可视化视频数据流中的动作和/或事件的系统和方法。 在一个实施例中，一种方法包括通过使用用于属性检测的动作识别过滤和提取的对象之间的关系检测的时间序列分析来动态地检测和提取与视频数据流相关的对象和属性。 此外，该方法可以包括通过将视频数据流描绘为相对稀疏或密集间隔的一系列帧来动态地生成沿着时间轴的多视场视频可视化，并且通过连续呈现与物体相关的属性 连续的抽象插图。 最后，一种方法还可以包括动态地组合检测和提取对象，并结合视频永久化（VPG）中的多场可视化，其可以并行地显示视频流，并且允许实时显示和交互 。

公开(公告)号：US07513988B2

公开(公告)日：2009-04-07

申请号：US11515018

申请日：2006-09-01

Applicant: Michael C. Oballa ,  Vasily Simanzhenkov ,  Jens Weitkamp ,  Roger Gläser ,  Yvonne Traa ,  Fehime Demir

Inventor： Michael C. Oballa ,  Vasily Simanzhenkov ,  Jens Weitkamp ,  Roger Gläser ,  Yvonne Traa ,  Fehime Demir

IPC: C10G45/44

CPC classification number: C10G45/44 ,  C10G45/48 ,  C10G45/50 ,  C10G45/58 ,  C10G65/12 ,  C10G2300/1096 ,  Y10S585/94

Abstract: Less conventional sources of hydrocarbon feedstocks such as oil sands, tar sands and shale oils are being exploited. These feedstocks generate a larger amount of heavy oil, gas oil, asphaltene products and the like containing multiple fused aromatic ring compounds. These multiple fused aromatic ring compounds can be converted into feed for a hydrocarbon cracker by first hydrogenating at least one ring in the compounds and subjecting the resulting compound to a ring opening and cleavage reaction. The resulting product comprises lower paraffins suitable for feed to a cracker, higher paraffins suitable for example as a gasoline fraction and mono aromatic ring compounds (e.g. BTX) that may be further treated.

Abstract translation: 正在开发较少常规的烃原料来源，如油砂，焦油砂和页岩油。 这些原料产生更多量的含有多个稠合芳环化合物的重油，瓦斯油，沥青质产物等。 这些多重稠合芳族环化合物可以通过首先氢化化合物中的至少一个环并使所得化合物进行开环和裂解反应而转化为烃裂化器的进料。 所得产物包含适于进料到裂化器的较低链烷烃，适合于例如汽油馏分的较高链烷烃和可进一步处理的单芳族环化合物（例如BTX）。

公开(公告)号：US20080209149A1

公开(公告)日：2008-08-28

申请号：US10563122

申请日：2004-07-01

Applicant: Matthias Meyer

Inventor： Matthias Meyer

IPC: G06F12/00 ,  G06F15/76

CPC classification number: G06F9/355 ,  G06F9/30003 ,  G06F9/30134 ,  G06F12/0253 ,  G06F2212/17

Abstract: The present invention relates to an object-based processor architecture which allows exact pointer identification by strictly separating pointers and data from one another in the memory and in the processor registers. The access to the memory is performed exclusively via pointers which refer to objects. An object contains separate areas for pointers and data and an attribute field for describing the length of the two areas. Both the pointers in the pointer registers and also the pointers in the pointer areas of the objects directly contain the address of the objects to which they refer. The suggested processor architecture allows the integration of automatic garbage collection, which may be implemented completely or partially in hardware. A real-time capable garbage collection may be implemented especially efficiently through hardware support.

Abstract translation: 本发明涉及一种基于对象的处理器架构，其通过在存储器和处理器寄存器中严格地分离指针和数据来允许精确的指针识别。 通过引用对象的指针来完成对存储器的访问。 对象包含用于指针和数据的单独区域，以及用于描述两个区域的长度的属性字段。 指针寄存器中的指针和对象的指针区域中的指针都直接包含它们引用的对象的地址。 建议的处理器架构允许集成自动垃圾收集，这可以完全或部分地在硬件中实现。 可以通过硬件支持特别有效地实现实时能力的垃圾收集。

公开(公告)号：US20080151253A1

公开(公告)日：2008-06-26

申请号：US11883413

申请日：2006-02-03

Applicant: Klaus Korner ,  Reinhard Berger ,  Ulrich Droste ,  Christian Kohler ,  Wolfgang Osten ,  Christof Pruss ,  Aiko Ruprecht ,  Tobias Wiesendanger

Inventor： Klaus Korner ,  Reinhard Berger ,  Ulrich Droste ,  Christian Kohler ,  Wolfgang Osten ,  Christof Pruss ,  Aiko Ruprecht ,  Tobias Wiesendanger

IPC: G01J3/45

CPC classification number: G11B7/1384 ,  G01B9/02036 ,  G01B9/02042 ,  G01B9/02044 ,  G01B9/02057 ,  G01B9/02091 ,  G01B2210/50 ,  G01B2290/15 ,  G02B3/0087 ,  G02B27/0025 ,  G11B7/1275 ,  G11B7/13 ,  G11B7/1381 ,  G11B7/14 ,  G11B7/24038 ,  G11B2007/0013

Abstract: An interferometric confocal method and assembly for terabyte volume optical data memories couples two-beam spectral interferometry to chromatic confocal technology and permits a longitudinal splitting of foci in the memory volume, with the foci having limited diffraction. A spectrometer is located downstream of the interferometer with confocal discrimination in the beam path. A diffractive optical zone lens (DOZE) with a usage of the first diffraction order is introduced into the interferometric beam path to achieve longitudinal chromatic splitting. The interferometer can be a fibre-coupled interferometer with a retroreflector in the fibre-coupled reference arm and with wavelength-dependent optical path difference modification by dispersion or diffraction. The optical path difference in the interferometer is set so that easily detectable wavelets are formed from detectable interferograms by spectral analysis.

Abstract translation: 用于太字节体积光学数据存储器的干涉式共焦方法和组件将双光束光谱干涉测量耦合到彩色共焦技术，并且允许在存储器体积中的焦点的纵向分割，其中焦点具有有限的衍射。 光谱仪位于干涉仪的下游，在光束路径中具有共焦识别。 将具有第一衍射级的使用的衍射光学透镜（DOZE）引入到干涉光束路径中以实现纵向色散。 干涉仪可以是在光纤耦合参考臂中具有回射器的光纤耦合干涉仪，并且通过色散或衍射与波长相关的光程差修改。 设置干涉仪中的光程差，使得通过光谱分析从可检测的干涉图形成容易检测的小波。

公开(公告)号：US20080044830A1

公开(公告)日：2008-02-21

申请号：US11722492

申请日：2005-12-02

Applicant: Gunter Tovar ,  Herwig Brunner ,  Achim Weber ,  Kirsten Borchers

Inventor： Gunter Tovar ,  Herwig Brunner ,  Achim Weber ,  Kirsten Borchers

IPC: G01N33/543 ,  C12N1/00 ,  C12Q1/00 ,  C12Q1/04 ,  H05H1/24 ,  G01N21/00 ,  G01N33/53

CPC classification number: G01N33/54346 ,  G01N33/54386

Abstract: The invention relates to functional elements that comprise, disposed on a support, microstructures containing biofunctionalized nanoparticles, methods for producing these functional elements and use of the same.

Abstract translation: 本发明涉及包括设置在载体上的包含生物功能化纳米颗粒的微结构的功能元件，用于制备这些功能元件的方法及其用途。

公开(公告)号：US20040110262A1

公开(公告)日：2004-06-10

申请号：US10045063

申请日：2002-01-15

Applicant: Degussa-Huls Aktiengesellschaft ,  Universitat Stuttgart ,  Roche Diagnostics GmbH

Inventor： Josef Altenbuchner ,  Ralf Mattes ,  Markus Pietzsch ,  Christoph Syldatk ,  Anja Wiese ,  Burkard Wilms

IPC: C12N009/16 ,  C07H021/04 ,  C12N001/21 ,  C12N015/74 ,  C12P021/02

CPC classification number: C12N9/80 ,  C12P13/04

Abstract: A novel rec-L-N-carbamoylase from Arthrobacter aurescens and its method of use for producing L-amino acids. The recombinantly produced L-carbamoylase is unexpectedly stable, so that an industrial method of producing L-amino acids can be established with it, in contrast to previously known L-carbamoylases.

Abstract translation: 来自节杆菌食管癌的新型rec-L-N-氨基甲酰化酶及其制备L-氨基酸的方法。 重组产生的L-氨基甲酰化酶是意想不到的稳定的，因此与之前已知的L-氨基甲酰化酶相反，可以与其建立L-氨基酸的工业生产方法。