公开(公告)号：US06396581B1

公开(公告)日：2002-05-28

申请号：US09492302

申请日：2000-01-27

Applicant: Toshinori Hayashi ,  Takahiko Ishiguro

Inventor： Toshinori Hayashi ,  Takahiko Ishiguro

IPC: G01N2164

CPC classification number: G01N21/645 ,  G01N21/253 ,  G01N35/025 ,  G01N2201/0231 ,  G01N2201/0423 ,  G01N2201/043 ,  G01N2201/0806 ,  G01N2201/0853

Abstract: A fluorescence detection apparatus is provided which comprises a sample holder for holding stationarily sample vessels deployed along a circle line or concentric circle lines having different radiuses, a partition plate connected to a driving means to be rotatable around the center of the circle line or concentric circle lines, an optical means for excitation light and an optical means for fluorescence light fixed respectively to the partition plate to be rotatable in integration therewith, a first light guide constituted of numerous optical fibers, a photosensor, and a light source for generating the excitation light, wherein the partition plate, the optical means for excitation light, and the optical means for fluorescence are integrally rotated, and thereby the fluorescence of the sample arranged along the circle line is successively detected and the detected fluorescence is transmitted to the photosensor. This fluorescence detection apparatus is useful in real-time monitoring of fluorescence signals, and satisfies the requirements of precise temperature control, quick treatment of many samples, high sensitivity, high reliability, low cost, and small size of the apparatus.

Abstract translation: 提供了一种荧光检测装置，其包括用于保持沿着圆线展开的固定样品容器的样本保持器或具有不同半径的同心圆线，连接到驱动装置的分隔板，以可围绕圆线或同心圆的中心旋转 线路，用于激发光的光学装置和用于荧光的光学装置分别固定在分隔板上以使其一体旋转;由多个光纤构成的第一导光体，光电传感器和用于产生激发光的光源 其中分隔板，用于激发光的光学装置和用于荧光的光学装置一体地旋转，从而连续检测沿着圆线排列的样品的荧光，并将检测到的荧光传输到光电传感器。 该荧光检测装置可用于实时监测荧光信号，满足精密温度控制，快速处理多种样品，高灵敏度，高可靠性，低成本，体积小的要求。

公开(公告)号：US20040189979A1

公开(公告)日：2004-09-30

申请号：US10486584

申请日：2004-02-11

Inventor： Shinji Fujimura ,  Tatsuya Harina ,  Kunikazu Taguchi

IPC: G01N021/00 ,  G01N021/55 ,  G01N021/47

CPC classification number: G01J3/02 ,  G01J3/0218 ,  G01J3/0229 ,  G01J3/0232 ,  G01J3/04 ,  G01J2003/326 ,  G01N21/253 ,  G01N21/474 ,  G01N21/55 ,  G01N21/59 ,  G01N2201/043

Abstract: There is presented a multipoint measurement system comprising light sources (1, 2); a plurality of illuminating fibers (5, 6) for transmitting light from the light sources to a sample so as to illuminate a plurality of points of the sample (A, B); a plurality of receiving fibers (8, 9) for collecting light beams including transmitted, reflected, scattered light beams at the plurality of points; a beam selector (10) which comprises a rotatable disk (12) having an aperture for transmitting a light beam collected by one of the plurality of receiving fibers (8, 9) through the receiving fiber (11); and an MCPD (4). When the rotatable disk (12) is rotated so that the aperture is displaced to and stops at a position at which light at the desired channel passes through, it is possible to perform measurement only on the light passing through the corresponding receiving fiber (8, 9, 11). Light at any other channel may be measured by rotating the rotatable disk (12) by a predetermined angle.

Abstract translation: 提出了包括光源（1,2）的多点测量系统; 多个照明光纤（5,6），用于将来自所述光源的光透射到样品以照射所述样品（A，B）的多个点; 多个接收光纤（8,9），用于在多个点处收集包括透射的，反射的散射光束的光束; 光束选择器（10），其包括具有用于透射通过所述接收光纤（11）从所述多个接收光纤（8,9）之一收集的光束的孔的可旋转盘（12）。 和一个MCPD（4）。 当可旋转盘（12）旋转使得孔径移动到并停止在期望通道上的光通过的位置时，可以仅对通过相应的接收光纤（8,8）的光进行测量， 9，11）。 可以通过将可旋转盘（12）旋转预定角度来测量任何其它通道处的光。