公开(公告)号：US20010000143A1

公开(公告)日：2001-04-05

申请号：US09726876

申请日：2000-11-30

Applicant: ROCHE VITAMINS INC.

Inventor： Alexander Bausch ,  Siegfried K. F. Peter ,  Kurt Steiner ,  Hansjorg Stoller ,  Eckhard Weidner

IPC: B01J002/00 ,  B01J002/04 ,  B01J002/06 ,  B29B009/00 ,  A61K009/14

CPC classification number: C07C403/24 ,  A61K9/146 ,  A61K9/1641 ,  A61K9/1688 ,  A61K31/015 ,  B01F2003/125 ,  Y02P20/544

Abstract: A process for producing pulverous, i.e., powdered, preparations from sparingly soluble solid materials is disclosed. The process utilizes dimethyl ether under conditions of elevated temperature and pressure to dissolve the solid material. Upon release of the pressure, the solid material precipitates as a fine powder and the gaseous dimethyl ether is released or drawn off.

公开(公告)号：US20020171159A1

公开(公告)日：2002-11-21

申请号：US10018462

申请日：2002-04-25

Inventor： Andre Matthaei ,  Peter Locker ,  Anreas Ecker ,  Ralf Muller

IPC: B01J002/04 ,  B29B009/12

CPC classification number: C08G63/88 ,  B01J2/04 ,  B01J2/30 ,  B29B9/10 ,  B29B9/16 ,  B29B2009/165 ,  B29K2067/00 ,  B29K2995/0041 ,  C08G63/785 ,  C08G63/80

Abstract: The invention relates to a process and an apparatus for forming molten drops of precursors of thermoplastic polyesters or copolyesters as molten monomer, oligomer, monomer/glycol mixture or after partial polycondensator nullsicnull and melting to give a molten precursor, in which the precursor formed into drops is introduced into a gaseous medium, and the gaseous medium, after entry of the precursor formed into drops into the gaseous medium, accelerates the crystallization process by holding the drop-form precursor at a temperature above 100null C. and below its melting point for a limited time until crystallization of the drop at the surface of the precursor is complete. To this end, the apparatus has a fall tower, through which the gaseous medium flows in countercurrent from bottom to top, while the drops fall in the vertical direction from top to bottom into a collecting funnel with a precrystallized surface.

Abstract translation: 本发明涉及用于形成作为熔融单体，低聚物，单体/二醇混合物或部分缩聚剂之后的热塑性聚酯或共聚酯的熔融液滴的熔融液的方法和装置，并熔融以得到熔融前体，其中形成前体 将液滴引入气态介质中，并且气体介质在形成液滴的前体进入气态介质之后，通过将液滴形式的前体保持在高于100℃并低于其熔点的温度加速结晶过程 点到有限的时间，直到前体表面的液滴结晶完成。 为此，该装置具有一个坠落塔，气体介质从底部向上流动，而液滴从上到下垂直于具有预结晶表面的收集​​漏斗。

公开(公告)号：US20020073511A1

公开(公告)日：2002-06-20

申请号：US09996020

申请日：2001-11-27

Inventor： Mazen H. Hanna ,  Peter York

IPC: B01J002/04 ,  B01D009/02

CPC classification number: A61K9/1688 ,  B01D11/0403 ,  B01D11/0407 ,  B01D11/0411 ,  B01D11/0488 ,  B01J2/04 ,  B01J3/008 ,  B01J3/02 ,  Y02P20/544

Abstract: The invention provides a method for forming particles of a substance, by co-introducing into a particle formation vessel, in which the temperature and pressure are controlled, of a supercritical fluid; a solution or suspension of the substance in a first vehicle; and a second vehicle which is both substantially miscible with the first vehicle and substantially soluble in the supercritical fluid in such a way that dispersion of the solution or suspension and the second vehicle, and extraction of the vehicles, occur substantially simultaneously and substantially immediately on introduction of the fluids into the vessel, by the action of the supercritical fluid. Preferably the solution suspension of the substance is introduced separately from the second vehicle, in such a way that contact between the solution/suspension and the second vehicle occurs either substantially simultaneously with, or immediately before, their dispersion by the supercritical fluid and extraction of the vehicles by the supercritical fluid. The method allows a high degree of control over the size, shape, crystalline form and other physico-chemical properties of the particulate product. The invention also provides apparatus for carrying out such a method, using a coaxial nozzle to introduce the fluids into the particle formation vessel, and a particulate product made using the method or the apparatus.

Abstract translation: 本发明提供了通过将超临界流体共同引入其中控制温度和压力的颗粒形成容器中来形成物质颗粒的方法; 该物质在第一种载体中的溶液或悬浮液; 以及第二种车辆，其基本上与第一辆车混合并且基本上溶解在超临界流体中，使得溶液或悬浮液和第二车辆的分散和车辆的提取基本上同时且基本上立即在引入时发生 的流体通过超临界流体的作用进入容器。 优选地，物质的溶液悬浮液与第二种载体分离地引入，使得溶液/悬浮液和第二载体之间的接触基本上与超临界流体分散或同时或之前由超临界流体分散出来， 车辆由超临界流体。 该方法允许高度控制颗粒产品的尺寸，形状，结晶形式和其他物理化学性质。 本发明还提供了一种使用同轴喷嘴将流体引入颗粒形成容器中的这种方法的装置，以及使用该方法或装置制成的颗粒状产品。