公开(公告)号：US06703607B2

公开(公告)日：2004-03-09

申请号：US10159766

申请日：2002-05-30

Applicant: William R. Stott ,  Bruce Collings ,  Frank Londry ,  James Hager

Inventor： William R. Stott ,  Bruce Collings ,  Frank Londry ,  James Hager

IPC: H01J4942

CPC classification number: H01J49/429 ,  H01J49/4225

Abstract: An improved method of operating a mass spectrometer having a linear ion trap wherein ions are axially ejected from the trap to a detector or subsequent mass analysis stage. The DC barrier field produced at the exit lens of the trap is scanned in conjunction with the scanning of other fields used to energize ions of select mass-to-charge ratios past the barrier field/exit lens. The technique can maximize the resolution obtainable from axial ejection over a wide mass range.

Abstract translation: 一种操作具有线性离子阱的质谱仪的改进方法，其中离子从捕集器轴向地从捕获器喷射到检测器或随后的质量分析阶段。 结合用于激励通过屏障场/出射透镜的选择质荷比的离子的其它场的扫描来扫描在阱的出射透镜处产生的DC势垒场。 该技术可以使在大质量范围内从轴向喷射获得的分辨率最大化。

公开(公告)号：US06674071B2

公开(公告)日：2004-01-06

申请号：US10313924

申请日：2002-12-06

Applicant: Jochen Franzen ,  Andreas Brekenfeld

Inventor： Jochen Franzen ,  Andreas Brekenfeld

IPC: H01J4942

CPC classification number: H01J49/062

Abstract: The invention relates to ion-guide systems for the transfer, cooling, fragmentation, selection and temporary storage of ions. The invention consists in embedding systems, made from one or more straight or curved rods to which a single or multiphase radio frequency voltage is applied, in an external enveloping dc potential. The combination of the ion-repelling radio-frequency pseudo field around the rods and the external dc voltage field represents a new category of ion-guide systems. With external dc voltage fields, whose strength or penetration into the interior of the rod system varies along the axis of the system, the ions can be collected or propelled along the axis of the system. Filling the system with collision or damping gas allows the ions to be fragmented and cooled without any losses and the phase space volumes of the ions to be greatly reduced.

Abstract translation: 本发明涉及用于离子的转移，冷却，分解，选择和临时储存的离子导向系统。 本发明包括在外部包络直流电位中由一个或多个直线或弯曲棒制成单个或多相射频电压的嵌入​​系统。 棒周围的离子排斥射频伪场与外部直流电压场的组合代表了一类新的离子导向系统。 使用外部直流电压场，其强度或穿透到杆系内部的系统沿系统的轴线变化，离子可以沿着系统的轴线被收集或推进。 用碰撞或阻尼气体填充系统允许离子被破碎和冷却而没有任何损失，并且离子的相空间体积将大大降低。

公开(公告)号：US06674067B2

公开(公告)日：2004-01-06

申请号：US10188577

申请日：2002-07-02

Applicant: Peter B. Grosshans ,  Chad M. Ostrander ,  Craig A. Walla

Inventor： Peter B. Grosshans ,  Chad M. Ostrander ,  Craig A. Walla

IPC: H01J4942

CPC classification number: H01J49/424 ,  H01J49/0095

Abstract: An ion trap mass spectrometer uses electrospray ionization to introduce multiply-charged positive ions in an axial direction into a quadrupole ion trap and glow discharge ionization to introduce singly-charged negative ions in a radial direction into the ion trap. Methods of controlling ion-to-ion charge transfer reactions include applying a combination of a dipolar DC voltage and a dipolar RF voltage across endcap electrodes to allow partial charge state neutralization reactions to occur between the positive and negative ions and then control suspension and resumption of further charge state neutralization reactions. The remaining ions can be further processed and transformed and a mass spectrum created by scanning a quadrupolar RF field.

Abstract translation: 离子阱质谱仪使用电喷雾离子化将多重带正电离子沿轴向引入四极离子阱，并进行辉光放电电离，将单离子带电负离子沿径向引入离子阱。 控制离子 - 离子电荷转移反应的方法包括在端帽电极上施加偶极DC电压和偶极RF电压的组合，以允许在正离子和负离子之间发生部分电荷状态中和反应，然后控制悬浮和恢复 进一步充电状态中和反应。 剩余的离子可以进一步处理和转化，并通过扫描四极RF场产生质谱。

公开(公告)号：US06646254B2

公开(公告)日：2003-11-11

申请号：US09845287

申请日：2001-05-01

Applicant: Yasufumi Tanaka

Inventor： Yasufumi Tanaka

IPC: H01J4942

CPC classification number: H01J49/067 ,  G01N30/724 ,  H01J49/044 ,  H01J49/063

Abstract: A liquid chromatograph mass spectrometer includes a solvent removing tube, a first ion lens and a second ion lens. Voltages applied to the solvent removing tube, and the first and second ion lenses corresponding to each mass number of a standard sample are studied in advance so that efficiencies of passing ions become best. A voltage scanning pattern is made based on the impressed voltages, and stored in a memory portion. When a scanning measurement is carried out, a control portion controls a current voltage source and a high frequency voltage source according to the voltage scanning pattern, synchronizing with the scanning of the impressed voltage to the quadrupole filter. As a result of the control, an objective ion which is generated by being atomized from a nozzle may effectively pass through the entrance of a quadrupole filter.

Abstract translation: 液相色谱质谱仪包括溶剂去除管，第一离子透镜和第二离子透镜。 预先施加到溶剂去除管的电压以及与标准样品的每个质量数对应的第一和第二离子透镜，使得通过离子的效率变得最佳。 基于外加电压进行电压扫描图案，并存储在存储器部分中。 当执行扫描测量时，控制部分根据电压扫描图案控制电流电压源和高频电压源，与向四极滤波器的外加电压的扫描同步。 作为控制的结果，通过从喷嘴雾化产生的客观离子可以有效地通过四极过滤器的入口。

公开(公告)号：US06590204B2

公开(公告)日：2003-07-08

申请号：US09845766

申请日：2001-05-02

Applicant: Vladimir Baranov

Inventor： Vladimir Baranov

IPC: H01J4942

CPC classification number: H01J49/0027

Abstract: A computer-based method for reducing chemical background in acquired electrospray and nanospray mass spectra, which comprises the steps of pre-processing an acquired mass spectrum, transforming the pre-processed mass spectrum into the frequency domain, reducing peaks in the transformed mass spectrum at calculated frequencies, applying an inverse transformation to the mass spectrum represented in the frequency domain, further processing and subsequent output of a mass spectrum with chemical background reduced. The invention enables rapid, automated generation of mass spectra with the component attributed to chemical background reduced, thereby allowing the mass spectrum to be analyzed more easily and effectively. The invention also generates mass spectra with improved signal-to-noise ratio and sample mass accuracy.

公开(公告)号：US06570151B1

公开(公告)日：2003-05-27

申请号：US10081243

申请日：2002-02-21

Applicant: Peter B. Grosshans ,  Chad M. Ostrander ,  Craig A. Walla

Inventor： Peter B. Grosshans ,  Chad M. Ostrander ,  Craig A. Walla

IPC: H01J4942

CPC classification number: H01J49/424 ,  H01J49/0095

Abstract: An ion trap mass spectrometer uses electrospray ionization to introduce multiply-charged positive ions in an axial direction into a quadrupole ion trap and glow discharge ionization to introduce singly-charged negative ions in a radial direction into the ion trap. Methods of controlling ion-to-ion charge transfer reactions include applying dipolar DC voltage across endcap electrodes to allow partial charge state neutralization reactions to occur between the positive and negative ions and then suspending further charge state neutralization reactions. The remaining ions can be further processed and transformed and a mass spectrum created by scanning a quadrupolar RF field.

Abstract translation: 离子阱质谱仪使用电喷雾离子化将多重带正电离子沿轴向引入四极离子阱，并进行辉光放电电离，将单离子带电负离子沿径向引入离子阱。 控制离子 - 离子电荷转移反应的方法包括在端帽电极上施加偶极DC电压，以允许在正离子和负离子之间发生部分电荷状态中和反应，然后暂停进一步的电荷状态中和反应。 剩余的离子可以进一步处理和转化，并通过扫描四极RF场产生质谱。

公开(公告)号：US06441370B1

公开(公告)日：2002-08-27

申请号：US09546748

申请日：2000-04-11

Applicant: Mukul Khosla ,  Berg Tehlirian

Inventor： Mukul Khosla ,  Berg Tehlirian

IPC: H01J4942

CPC classification number: H01J49/063 ,  H01J49/068 ,  H01J49/4215 ,  H01J49/4225 ,  H01J49/4255

Abstract: A multiple-pole electrode assembly is disclosed for use in mass spectrometers or other applications such as ion traps or ion guides. The disclosed apparatus provides a rod mounting and connection assembly in which equally spaced rectangular rods are embedded in spaced, dimensionally stable insulating materials. This structure is more conveniently and inexpensively manufactured than previously available multiple pole electrode assemblies.

Abstract translation: 公开了用于质谱仪或其它应用如离子阱或离子导向器的多极电极组件。 所公开的装置提供了杆安装和连接组件，其中等间隔的矩形杆被嵌入间隔开的尺寸稳定的绝缘材料中。 该结构比先前可用的多极电极组件更方便和廉价地制造。

公开(公告)号：US06204510B1

公开(公告)日：2001-03-20

申请号：US09215976

申请日：1998-12-18

Applicant: Tihiro Ohkawa

Inventor： Tihiro Ohkawa

IPC: H01J4942

CPC classification number: H01J37/32568 ,  H01J37/04 ,  H01J37/32541 ,  H01J37/32559 ,  H01J2237/08

Abstract: An apparatus for altering the surface of a substrate includes a housing that is formed with an enclosed chamber having a first end and a second end. The chamber defines a longitudinal axis extending between the ends, and the substrate is positioned near the second end. A set of conductors are mounted in the chamber parallel to the longitudinal axis, and each conductor carries a current to establish a magnetic field (B) in said chamber. A first casing and a second casing surround each conductor with time alternating voltages being applied on the set of first casings to generate a plasma. The second casings are electrically insulated from a respective first casing so that a dc voltage can be applied to the second casings in a manner which ensures the potential of the resultant electric field (E) in the chamber is proportional to the magnetic flux. The electric field so produced is thereby crossed with the magnetic field (E×B) to uniformly accelerate plasma ions in a direction substantially parallel to the longitudinal axis from the first end toward the second end of the chamber to impact and thereby alter the substrate surface.

Abstract translation: 用于改变基材表面的装置包括壳体，该壳体形成有具有第一端和第二端的封闭室。 腔室限定在端部之间延伸的纵向轴线，并且衬底位于第二端附近。 一组导体安装在平行于纵向轴线的腔室中，并且每个导体承载电流以在所述腔室中建立磁场（B）。 第一壳体和第二壳体围绕每个导体，时间交替电压施加在该组第一壳体上以产生等离子体。 第二壳体与相应的第一壳体电绝缘，使得可以以确保室内的所得电场（E）的电位与磁通量成比例的方式将直流电压施加到第二壳体。 由此产生的电场与磁场（ExB）交叉，从而从腔的第一端到第二端基本上平行于纵向轴线的方向均匀地加速等离子体离子，从而冲击衬底表面。

公开(公告)号：US06180941B2

公开(公告)日：2001-01-30

申请号：US09447578

申请日：1999-11-23

Applicant: Yasuaki Takada ,  Minoru Sakairi ,  Takayuki Nabeshima ,  Yukiko Hirabayashi ,  Hideaki Koizumi

Inventor： Yasuaki Takada ,  Minoru Sakairi ,  Takayuki Nabeshima ,  Yukiko Hirabayashi ,  Hideaki Koizumi

IPC: H01J4942

CPC classification number: H01J49/067 ,  H01J49/04

Abstract: A mass spectrometer comprising an ionization means for ionizing sample compounds to be analyzed mass spectro-scopically in an atmospheric pressure, a sample solution supply means for supplying a solution containing the sample compounds to the ionization means, means for feeding the ions formed by the ionization means through an aperture disposed in an electrode into a vacuum region, and an ion trap type mass spectroscopic means for mass spectroscopically analyzing ions entered through the aperture into the vacuum region, in which an ion decelerating electric field forming means is disposed between the electrode disposed with the aperture and an electrode disposed with an ion entrance opening for entering the ions into the ion trap type mass spectroscopic means for forming an electric field for decelerating the ions, and the ions injected to the ion trap mass spectroscopic means is lowered. This facilitates accumulation ions in the ion trap mass spectralyzing means even if a high drift voltage is used thereby enabling high sensitivity analysis for polar compounds such as peptides.

Abstract translation: 一种质谱仪，其特征在于，包括：离子化装置，用于将大气压力分析分析的样品化合物离子化;将含有样品化合物的溶液供给到电离装置的样品溶液供给装置， 意味着通过设置在电极中的孔进入真空区域，以及离子阱型质谱分析装置，用于质谱分析通过孔进入真空区域的离子，其中离子减速电场形成装置设置在设置的电极之间 其中所述孔和电极设置有离子入口，用于将离子进入离子阱型质谱分析装置，用于形成用于使离子减速的电场，并且注入离子阱质谱分析装置的离子降低。 即使使用高漂移电压，这也有助于离子阱质谱分析手段中的积聚离子，从而能够对极性化合物如肽进行高灵敏度分析。

公开(公告)号：US06797963B2

公开(公告)日：2004-09-28

申请号：US10617703

申请日：2003-07-14

Applicant: Sang Kuk Choi ,  Dae Yong Kim ,  Dong Yel Kang

Inventor： Sang Kuk Choi ,  Dae Yong Kim ,  Dong Yel Kang

IPC: H01J4942

CPC classification number: H01J9/02 ,  B82Y10/00 ,  B82Y40/00 ,  H01J3/26 ,  H01J37/1477 ,  H01J37/3174 ,  H01J37/3177 ,  H01J2237/1516 ,  H01J2237/31793

Abstract: The present invention relates to a deflector of a micro-column electron beam apparatus and method for fabricating the same, which forms a seed metal layer and a mask layer on both sides of a substrate, and exposes some of the seed metal layer on which deflecting plates, wirings and pads are to be formed by lithography process using a predetermined mask. The wirings and pads are formed by plating metal on the exposed portion, and some of the metal layer is also exposed on which the deflecting plates are to be formed using a predetermined mask, and then the metal is plated with desired thickness, thereby the deflecting plates are completed. Therefore, by forming plurality of deflecting plates on both sides of the substrate at the same time through plating process, alignment between the deflecting plates formed on both sides of the substrate can be exactly made, and by fabricating a deflector integrated with the substrate and deflecting plates in a batch process, productivity and reproducibility is improved. In addition, since the deflecting plates, wirings and pads are directly formed on the substrate, structural safety is improved and thereby durability is also improved.