公开(公告)号：WO2011111073A4

公开(公告)日：2012-01-05

申请号：PCT/IN2011000162

申请日：2011-03-10

Applicant: BHADALAKAR ANAND ,  DESAI PIYUSH

Inventor： BHADALAKAR ANAND ,  DESAI PIYUSH

IPC: C12P13/08 ,  C07D201/08

CPC classification number: C12P13/08

Abstract: A process of biogenesis of L-Lysine from e-caprolactam or e-caprolactam degradation or related intermediates selected from e-Amino Caproic Acid (AC A), Amino Adipic Acid, Adipic Acid, Norlecucine or any combinations thereof, by microorganisms or their enzymes, and more particularly microorganisms belonging to groups selected from Alcaligenes spp., Arthrobacter spp., Bacillus spp., Pseudomonas spp. and Rhodococcus spp., in a reaction medium is provided. The biotransformation process is performed leading to biogenesis of L-Lysine from e-caprolactam or e-caprolactam degradation or related intermediates selected from e-Amino Caproic Acid (AC A), Amino Adipic Acid, Adipic Acid, Norlecucine or any combinations thereof, in presence of any or combinations of modulators or inhibitors, and then isolating the L-Lysine from the reaction mixture. A process of biogenesis of L-Lysine from e-caprolactam or e-caprolactam degradation or related intermediates selected from e-Amino Caproic Acid [ACA], Amino Adipic Acid, Adipic Acid, NorLeucine or any combinations thereof, by microorganisms or their enzymes, and more particularly microorganisms belonging to groups Alcaligenes spp., Arthrobacter spp., Bacillus spp., Pseudomonas spp. and Rhodococcus spp.; in a reaction medium. The biotransformation process is performed leading to biogenesis of L-Lysine from e-caprolactam or e-caprolactam degradation or related intermediates selected from e-Amino Caproic Acid [ACA], Amino Adipic Acid, Adipic Acid, NorLeucine or combination thereof, in presence of any or combination of modulators/ inhibitors, and then isolating the L-Lysine from the reaction mixture.

Abstract translation: 通过微生物或其酶从ε-己内酰胺或ε-己内酰胺降解或选自E-氨基己酸（ACA），氨基己二酸，己二酸，非参考色氨酸或其任何组合的相关中间体生物生成L-赖氨酸的方法 更特别是属于选自产碱杆菌属（Arcaligenes spp。），节杆菌属（Arthrobacter spp。），芽孢杆菌属（Bacillus spp。），假单胞菌属（Pseudomonas spp） 和红球菌属（Rhodococcus spp。），在反应介质中。 进行生物转化过程导致L-己内酰胺或ε-己内酰胺降解的L-赖氨酸的生物发生或选自E-氨基己酸（ACA），氨基己二酸，己二酸，非焦氨酸或其任何组合的相关中间体， 存在调节剂或抑制剂的任何或组合，然后从反应混合物中分离L-赖氨酸。 通过微生物或它们的酶从ε-己内酰胺或ε-己内酰胺降解或选自e-氨基己酸[ACA]，氨基己二酸，己二酸，NorLeucine或其任何组合的相关中间体生物发生L-赖氨酸的方法， 更特别是属于产碱杆菌属，节杆菌属，芽孢杆菌属，假单胞菌属（Pseudomonas spp。）的微生物。 和红球菌属（Rhodococcus spp 在反应介质中。 进行生物转化过程导致L-己内酰胺或ε-己内酰胺降解的L-赖氨酸的生物发生或选自E-氨基己酸[ACA]，氨基己二酸，己二酸，NorLeucine或其组合的相关中间体，在 任何或组合的调节剂/抑制剂，然后从反应混合物中分离L-赖氨酸。

公开(公告)号：WO2011078668A1

公开(公告)日：2011-06-30

申请号：PCT/NL2010/050878

申请日：2010-12-22

Applicant: DSM IP Assets B.V. ,  GUIT, Rudolf Philippus Maria ,  VAN DER DOES, Thomas ,  RAAMSDONK, Lourina Madeleine

Inventor： GUIT, Rudolf Philippus Maria ,  VAN DER DOES, Thomas ,  RAAMSDONK, Lourina Madeleine

IPC: C07D201/08 ,  C07D223/10

CPC classification number: C07D201/08 ,  C07D201/16 ,  C07D223/10 ,  C08G69/16

Abstract: The invention relates to a method for preparing caprolactam comprising recovering a mixture containing 6-aminocaproic acid, from a culture medium comprising biomass, and thereafter cyclising the 6-aminocaproic acid in the presence of superheated steam, thereby forming caprolactam, wherein the weight to weight ratio carbohydrate to 6-aminocaproic acid in said mixture is 0.03 or less.

Abstract translation: 本发明涉及一种制备己内酰胺的方法，包括从含有生物质的培养基中回收含有6-氨基己酸的混合物，然后在过热蒸汽存在下环化6-氨基己酸，从而形成己内酰胺，其中重量 所述混合物中碳水化合物与6-氨基己酸的比例为0.03以下。

公开(公告)号：WO2006101870A1

公开(公告)日：2006-09-28

申请号：PCT/US2006/009231

申请日：2006-03-15

Applicant: INVISTA TECHNOLOGIES S.A R.L. ,  ALLGEIER, Alan, M. ,  OSTERMAIER, John, J. ,  SENGUPTA, Sourav, K.

Inventor： ALLGEIER, Alan, M. ,  OSTERMAIER, John, J. ,  SENGUPTA, Sourav, K.

IPC: C07D201/08 ,  C07D223/10

CPC classification number: C07D223/10

Abstract: The invention relates to the field of production of lactams from aminonitriles, and in particular to the production of ε-caprolactam by the vapor phase hydrolytic cyclization of 6-aminocapronitrile. A crude liquid caprolactam comprising ε-caprolactam (CL), 6-aminocapronitrile (ACN) and water obtained from a vapor phase cyclization reaction of ACN is contacted with hydrogen in the presence of a hydrogenation catalyst to convert the ACN in the crude liquid caprolactam to a product comprising hexamethylenediamine (HMD) and hexamethyleneimine (HMI). Tetrahydroazepine (THA) in the crude liquid caprolactam is converted to HMI during this hydrogenation. The HMD and HMI have lower boiling points compared to ACN and thus they are more easily separated from CL in the subsequent distillation operations. Thus a process to make CL from ACN with fewer distillation stages, and with lower pressure drop and lower base temperature, is accomplished.

Abstract translation: 本发明涉及由氨基腈生产内酰胺的领域，特别涉及通过6-氨基己腈的气相水解环化生产ε-己内酰胺。 将包含ε-己内酰胺（CL），6-氨基己腈（ACN）和ACN的气相环化反应得到的水的粗液体己内酰胺在氢化催化剂存在下与氢气接触，将粗液体己内酰胺中的ACN转化为 包括六亚甲基二胺（HMD）和六亚甲基亚胺（HMI）的产品。 粗液体己内酰胺中的四氢吖庚因（THA）在该氢化期间转化为HMI。 与ACN相比，HMD和HMI具有较低的沸点，因此在随后的蒸馏操作中它们更容易与CL分离。 因此，实现了具有较少蒸馏阶段以及较低压降和较低基础温度的来自ACN的CL的方法。

公开(公告)号：WO2004113288A1

公开(公告)日：2004-12-29

申请号：PCT/US2004/019432

申请日：2004-06-17

Applicant: INVISTA TECHNOLOGIES S.A.R.L. ,  KIRBY, Gregory S. ,  OSTERMAIER, John J.

Inventor： KIRBY, Gregory S. ,  OSTERMAIER, John J.

IPC: C07D201/08

CPC classification number: C07D223/04

Abstract: Method for making caprolactam from 6-aminocapronitrile that contains greater than 500 ppm tetrahydroazepine and its derivatives (THA) in which ammonia and water are removed from crude caprolactam in a single separation step and then THA is removed from the resulting caprolactam melt.

Abstract translation: 从单一分离步骤中，从含有大于500ppm四氢氮杂及其衍生物（THA）的六氨基己腈制备己内酰胺的方法，其中氨和水从粗己内酰胺中除去，然后从所得己内酰胺熔体中除去THA。

公开(公告)号：WO0228525A9

公开(公告)日：2002-11-28

申请号：PCT/NL0100728

申请日：2001-10-03

Applicant: DSM NV ,  GUIT RUDOLF PHILIPPUS MARIA ,  NOTTEN MATHIEU JOHANNES GUILLA ,  PESTMAN ROBERT

Inventor： GUIT RUDOLF PHILIPPUS MARIA ,  NOTTEN MATHIEU JOHANNES GUILLA ,  PESTMAN ROBERT

IPC: B01J19/02 ,  B01J19/24 ,  B01J23/46 ,  C07D201/08

CPC classification number: B01J19/02 ,  B01J23/462 ,  B01J2219/0236 ,  B01J2219/0277 ,  B01J2219/0286 ,  C07D201/08

Abstract: Process for the preparation of a mixture of epsilon -caprolactam and epsilon -caprolactam precursors by reductively aminating 5-formylvaleric acid and/or 5-formylvalerate ester(s) in water with hydrogen and an excess of ammonia in the presence of a hydrogenation catalyst, wherein the process is conducted in a reactor of which the inside reactor wall material is a material containing at most 8 wt.% nickel.

Abstract translation: 通过在氢化催化剂存在下，用氢气和过量的氨将水中的5-甲酰戊酸和/或5-甲酰戊酸酯还原胺化制备ε-己内酰胺和ε-己内酰胺前体的混合物的方法， 其中所述方法在其内反应器壁材料是含有至多8重量％镍的材料的反应器中进行。

公开(公告)号：WO0177068A3

公开(公告)日：2002-08-08

申请号：PCT/US0109951

申请日：2001-03-28

Applicant: DU PONT

Inventor： KOCH THEODORE AUGUR ,  ALLGEIER ALAN MARTIN ,  HARPER MARK JAY ,  SENGUPTA SOURAV KUMAR

IPC: C07D223/04 ,  C07B61/00 ,  C07C231/12 ,  C07C237/06 ,  C07D201/02 ,  C08G69/14 ,  C07D201/08

CPC classification number: C07C231/12 ,  C07C237/06

Abstract: A process for the production of 6-aminocaproamide comprising reacting 5-cyanovaleramide with hydrogen in the presence of a metal catalyst. The 6-aminocaproamide is useful, for example, in the production of caprolactam and nylon 6.

Abstract translation: 一种生产6-氨基己酰胺的方法，包括在金属催化剂存在下使5-氰基戊酰胺与氢气反应。 6-氨基己酰胺可用于例如己内酰胺和尼龙6的制备。

公开(公告)号：WO01096294A1

公开(公告)日：2001-12-20

申请号：PCT/EP2001/006687

申请日：2001-06-13

IPC: C07D233/10 ,  C07B61/00 ,  C07D201/08 ,  C07D223/10

CPC classification number: C07D201/08 ,  Y02P20/52

Abstract: The invention relates to a method for the production of caprolactam from a compound of formula (I): NC-(CH2)5-CO-R where R = a carboxamido, carboxlic acid or carboxylate ester group, characterised in that a) a compound (I), or mixtures thereof are hydrogenated with hydrogen in the presence of ammonia, a catalyst (II) and optionally a fluid solvent (VI) to give a mixture (III), b) separation of catalyst (II) and hydrogen from the mixture (III) to give a mixture (IV) and c) reaction of mixture (IV), in the presence of a catalyst (V) and optionally a fluid solvent (VII), to give caprolactam.

Abstract translation: NC-（CH2）5-CO-R，其中R：羧酸酰胺，羧酸或其特征在于羧酸酯基）的化合物（I）或它们的混合物，一种从式（I）的化合物的制备己内酰胺的方法 如果合适的液体稀释剂（VI）在催化剂（II）的存在下氢氨和存在下进行氢化，得到的混合物（III），b）从所述混合物（III）为氢和催化剂（II）被分离，得到的混合物（IV） 和c）将混合物（IV）任选的（在液体稀释剂VII的在催化剂（V）的存在下存在）的反应，己内酰胺。

公开(公告)号：WO01083443A1

公开(公告)日：2001-11-08

申请号：PCT/EP2001/004837

申请日：2001-04-30

IPC: C07D223/12 ,  C07D201/08

CPC classification number: C07D201/08

Abstract: The invention relates to a method for producing caprolactam, which is characterized by a) reacting, in the presence of a catalyst, a mixture (I) that contains 6-aminocapronitrile and water in the gaseous phase to give a mixture (II) that contains caprolactam, ammonia, water, high-boiling and low-boiling substances, subsequently b) removing the ammonia from mixture (II), thereby producing a mixture (III) that contains caprolactam, water, high-boiling and low-boiling substances, c) removing the water from mixture (III), thereby producing a mixture (IV) that contains caprolactam, high-boiling and low-boiling substances, and finally d) obtaining by crystallization a caprolactam-containing solid substance (V) from mixture (IV), the weight percentage of caprolactam in the solid substance (V) being higher than in mixture (IV).

Abstract translation: 一种用于含有己内酰胺，氨，水，高沸点和低沸点在催化剂的存在下，然后将包含在气相中（共混物II）6-氨基己腈与水在制备己内酰胺，其特征在于，a）的混合物（I）的过程 b）从所述混合物（II）的氨除去，得到含有己内酰胺，高沸点和低沸点的混合物（III），其包括从（III）的水被除去，混合物己内酰胺，水，高沸点和低沸点，然后c）（以得到的混合物IV），和 然后d）为从混合物（IV）由结晶化的含有己内酰胺的固体（V），其特征在于，按重量计在固体（V己内酰胺的比例）比在混合物（IV）大。

公开(公告)号：WO9951568A3

公开(公告)日：1999-11-18

申请号：PCT/US9906822

申请日：1999-03-29

Applicant: DU PONT PHARM CO

Inventor： ZHOU JICHENG ,  OH LYNETTE MAY ,  MA PHILIP

IPC: C07D261/08 ,  C07B61/00 ,  C07C253/00 ,  C07C255/17 ,  C07C255/40 ,  C07D201/08

CPC classification number: C07C253/00 ,  C07D201/08 ,  C07C255/17 ,  C07C255/40

Abstract: The present invention relates to processes for the production of alpha -aryl- beta -ketonitriles, which serve as synthetic intermediates in the preparation of a series of biologically important molecules such as corticotropin releasing factor (CRF) receptor antagonists.

Abstract translation: 本发明涉及制备α-芳基-β-酮腈的方法，其用作制备一系列重要生物学分子如促肾上腺皮质激素释放因子（CRF）受体拮抗剂的合成中间体。

公开(公告)号：WO99048867A1

公开(公告)日：1999-09-30

申请号：PCT/NL1999/000148

申请日：1999-03-17

IPC: C07D201/08 ,  C07D201/16

CPC classification number: C07D201/08 ,  C07D201/16

Abstract: The invention relates to a process for the purification of crude epsilon -caprolactam, wherein crude epsilon -caprolactam prepared by cyclization of alkyl 6-aminocaproate, 6-aminocapronitrile, 6-aminocaproic acid, 6 aminocaproic amide and/or oligomers thereof, is subjected to a crystallization process.

Abstract translation: 本发明涉及一种纯化ε-己内酰胺的方法，其中将通过6-氨基己酸烷基酯，6-氨基己腈，6-氨基己酸，6-氨基己酰胺和/或其低聚物的环化制备的粗ε-己内酰胺进行 结晶过程。