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公开(公告)号：WO2016175901A2
公开(公告)日：2016-11-03
申请号：PCT/US2015/067099
申请日：2015-12-21
Inventor： BOTES, Adriana Leonora , CONRADIE, Alex Van Eck
IPC: C12P7/26
CPC classification number: C12P19/32 , C07H1/00 , C07H19/207 , C12N9/1029 , C12P7/18 , C12P7/24 , C12P7/26 , C12P7/42 , C12P7/44 , C12P13/001 , C12P13/005 , C12P17/10 , C12Y203/01
Abstract: This document describes materials and methods for, for example, producing 6-hydroxyhexanoic acid using a β-ketothiolase or synthase and an alcohol O-acetyltransferase to form a 6-acetyloxy-3-oxohexanoyl-CoA intermediate. This document describes biochemical pathways for producing 6-hydroxyhexanoic acid using a β-ketothiolase or synthase and an alcohol O-acetyltransferase to form a 6-acetyloxy-3-oxohexanoyl-CoA intermediate. 6-hydroxyhexanoic acid can be enzymatically converted to adipic acid, caprolactam, 6-aminohexanoic acid, hexamethylenediamine or 1,6-hexanediol. This document also describes recombinant hosts producing 6-hydroxyhexanoic acid as well as adipic acid, caprolactam, 6-aminohexanoic acid, hexamethylenediamine and 1,6-hexanediol.
Abstract translation: 该文献描述了例如使用β-酮硫解酶或合酶和醇O-乙酰转移酶产生6-羟基己酸以形成6-乙酰氧基-3-氧代己酰-CoA中间体的材料和方法。 本文件描述了使用β-酮硫解酶或合酶和醇O-乙酰转移酶生成6-羟基己酸的生物化学途径以形成6-乙酰氧基-3-氧代己酰-CoA中间体。 6-羟基己酸可以酶促转化为己二酸，己内酰胺，6-氨基己酸，六亚甲基二胺或1,6-己二醇。 该文献还描述了生产6-羟基己酸以及己二酸，己内酰胺，6-氨基己酸，六亚甲基二胺和1,6-己二醇的重组宿主。
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公开(公告)号：WO2016085816A1
公开(公告)日：2016-06-02
申请号：PCT/US2015/061892
申请日：2015-11-20
Inventor： BOTES, Adriana Leonora , CONRADIE, Alex Van Eck , HADDOUCHE, Ramdane
CPC classification number: C12N9/0071 , C07C47/12 , C07C47/19 , C07C49/185 , C07C223/02 , C07C229/08 , C07C229/12 , C12N9/0008 , C12N9/0073 , C12N9/18 , C12N9/20 , C12P7/42 , C12P7/44 , C12P7/6409 , C12Y114/13 , C12Y114/14001 , C12Y301/01001 , C12Y301/01003
Abstract: This document describes biochemical pathways for producing 6-hydroxyhexanoic acid using a monooxygenase to form a 7-hydroxyoctanoate intermediate, which can be converted to 6-hydroxyhexanoate using a polypeptide having monooxygenase , secondary alcohol dehydrogenase , or esterase activity. 6-hydroxyhexanoic acid can be enzymatically converted to adipic acid, caprolactam, 6-aminohexanoic acid, hexamethylenediamine or 1,6-hexanediol. This document also describes recombinant hosts producing 6-hydroxyhexanoic acid as well as adipic acid, caprolactam, 6-aminohexanoic acid, hexamethylenediamine and 1,6-hexanediol.
Abstract translation: 该文献描述了使用单加氧酶形成7-羟基辛酸酯中间体生产6-羟基己酸的生物化学途径，其可以使用具有单加氧酶，仲醇脱氢酶或酯酶活性的多肽转化为6-羟基己酸酯。 6-羟基己酸可以酶促转化为己二酸，己内酰胺，6-氨基己酸，六亚甲基二胺或1,6-己二醇。 该文献还描述了生产6-羟基己酸以及己二酸，己内酰胺，6-氨基己酸，六亚甲基二胺和1,6-己二醇的重组宿主。
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公开(公告)号：WO2016106247A1
公开(公告)日：2016-06-30
申请号：PCT/US2015/067187
申请日：2015-12-21
Inventor： BOTES, Adriana Leonora , CONRADIE, Alex Van Eck
CPC classification number: C12P7/6409 , C07C59/01 , C07H19/207 , C12N9/0006 , C12N9/001 , C12N9/1029 , C12P7/18 , C12P13/001 , C12P13/005 , C12P19/32 , C12Y101/01035 , C12Y101/0133 , C12Y103/01038 , C12Y203/01 , C12Y402/01007 , C12Y402/01017
Abstract: This document describes materials and methods for producing 7-hydroxyheptanoic acid using a β-ketothiolase or a synthase and an alcohol O-acetyltransferase to form a 7-acetyloxy-3-oxoheptanoyl-CoA intermediate. This document describes biochemical pathways for producing 7-hydroxyheptanoic acid using a β-ketothiolase or a synthase and an alcohol O-acetyltransferase to form a 7-acetyloxy-3-oxoheptanoyl-CoA intermediate. 7-hydroxyheptanoic acid can be enzymatically converted to pimelic acid, 7-aminoheptanoic acid, heptamethylenediamine or 1,7 heptanediol. This document also describes recombinant hosts producing 7-hydroxyheptanoic acid as well as pimelic acid, 7-aminoheptanoic acid, heptamethylenediamine and 1,7 heptanediol.
Abstract translation: 本文件描述了使用β-酮硫解酶或合酶和醇O-乙酰转移酶产生7-羟基庚酸的材料和方法，以形成7-乙酰氧基-3-氧代庚酰基-CoA中间体。 该文献描述了使用β-酮硫解酶或合酶和醇O-乙酰转移酶产生7-羟基庚酸的生物化学途径以形成7-乙酰氧基-3-氧代庚酰基-CoA中间体。 7-羟基庚酸可以酶促转化成庚二酸，7-氨基庚酸，七亚甲基二胺或1,7庚二醇。 该文献还描述了产生7-羟基庚酸以及庚二酸，7-氨基庚酸，七亚甲基二胺和1,7庚二醇的重组宿主。
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公开(公告)号：WO2015195707A1
公开(公告)日：2015-12-23
申请号：PCT/US2015/036092
申请日：2015-06-16
Applicant: INVISTA TECHNOLOGIES S.A.R.L.
Inventor： BOTES, Adriana Leonora , CONRADIE, Alex Van Eck
CPC classification number: C12P13/001 , C08G69/26 , C12N9/00 , C12N9/0008 , C12N9/1096 , C12N15/52 , C12P7/18 , C12P7/40 , C12P7/42 , C12P7/44 , C12P7/62 , C12P13/04 , C12Y102/99006 , C12Y206/01018
Abstract: This document describes biochemical pathways for producing glutaric acid, 5-aminopentanoic acid, 5-hydroxypentanoic acid, cadaverine or 1,5-pentanediol by forming one or two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C5 backbone substrate such as 2-oxoglutarate, the substrate being 2-oxo-adipate.
Abstract translation: 本文件描述了通过在C5主链基质中形成一个或两个由羧基，胺或羟基组成的末端官能团来生产戊二酸，5-氨基戊酸，5-羟基戊酸，尸胺或1,5-戊二醇的生化途径 例如2-氧戊二酸酯，底物是2-氧代己二酸酯。
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