公开(公告)号：WO01040178A1

公开(公告)日：2001-06-07

申请号：PCT/NL2000/000879

申请日：2000-11-30

IPC: C07D201/02

CPC classification number: C07D201/02

Abstract: Process for the preparation of a carboxylic acid derivative according to general formula (I) where the fragments X are a lactam, an oxime or an imide in the form of HX, by mixing HX with phosgene, with hydrogen chloride being removed in gaseous form from the mixture formed. This can be accomplished by not adding any base to the reaction mixture. The invention also relates to carbonylbiscaprolactam, characterized in that the water content is lower than 250 ppm and the chlorine content is lower than 300 ppm. The invention also relates to a process for increasing the molecular weight of a polymer by mixing an -OH- or -NH2-functional polymer in the melt with a carboxylic acid derivative according to formula (I), characterized in that the carboxylic acid derivative has a water content of less than 250 ppm and a chlorine content of less than 300 ppm.

Abstract translation: 制备根据通式（I）的羧酸衍生物的方法，其中片段X为HX形式的内酰胺，肟或酰亚胺，通过将HX与光气混合，以氯气从气态中除去 混合物形成。 这可以通过不向反应混合物中添加任何碱来实现。 本发明还涉及羰基双己内酰胺，其特征在于水含量低于250ppm，氯含量低于300ppm。 本发明还涉及通过将熔体中的-OH或-NH 2官能的聚合物与式（I）的羧酸衍生物混合来提高聚合物的分子量的方法，其特征在于羧酸衍生物具有 水含量低于250ppm，氯含量低于300ppm。

公开(公告)号：WO00017160A1

公开(公告)日：2000-03-30

申请号：PCT/EP1999/006691

申请日：1999-09-10

IPC: C07D223/10 ,  C07D201/02 ,  C07D201/08 ,  C07D223/04 ,  C07D295/023 ,  C07D295/02

CPC classification number: C07D201/02 ,  C07D201/08 ,  C07D295/023

Abstract: The invention relates to a method for simultaneously producing a cyclic lactam and a cyclic amine by simultaneously reacting an aliphatic alpha, omega diamine and an aliphatic alpha, omega aminonitrile in the gas phase with water and in the presence of a heterogeneous catalyst.

Abstract translation: 一种用于环状内酰胺的制备联合和通过脂肪族α，ω-二胺的欧米加氨基腈与水在非均相催化剂的存在下同时反应和脂族α，在气相中的环状胺的过程。

公开(公告)号：WO98046564A1

公开(公告)日：1998-10-22

申请号：PCT/US1998/007486

申请日：1998-04-14

IPC: E02B5/08 ,  C02F1/00 ,  C07C29/16 ,  C07C45/49 ,  C07C45/50 ,  C07C45/68 ,  C07C47/19 ,  C07D201/02 ,  C07D201/08 ,  C07D213/16 ,  C07D213/30 ,  C07D213/55 ,  C07F9/6574 ,  C08G69/02 ,  C08G69/14 ,  C08G69/36

CPC classification number: C07D201/02 ,  C07C45/49 ,  C07C45/50 ,  C07C45/68 ,  C07C47/19 ,  C07D201/08 ,  C07F9/65744 ,  C08G69/02 ,  C08G69/14 ,  C08G69/36 ,  Y02P20/582

Abstract: This invention relates to a composition commprising (a) epsilon caprolactam and (b) one or more of 5-[4,5-di(3-carboxypropyl)-2-pyridyl]pentanoic acid or salt or amide, 4-[4,5-di(2-carboxypropyl)-2-pyridyl]-2-methylbutanoic acid or salt or amide, 2-[2-(2-carboxybutyl)-5-(1-carboxypropyl)-4-pyridyl]butanoic acid or salt or amide, 5-[3,5-di(3-carboxypropyl)-2-pyridyl]pentanoic acid or salt or amide, 4-[3,5-di(2-carboxypropyl)-2-pyridyl]-2-methylbutanoic acid or salt or amide, 2-[2-(2-carboxybutyl)-5-(1-carboxypropyl)-3-pyridyl]butanoic acid or salt or amide, 5-amino-4-methylpentanamide, 4-amino-3-ethylbutanamide, 5-[4,5-di(4-hydroxybutyl)-2-pyridyl]pentanol, 4-[4,5-di(2-methoxypropyl)-2-pyridyl]-2-methylbutanol, 2-[2-(2-methoxybutyl)-5-(1-methoxypropyl)-4-pyridyl]butanol, 5-[3,5-di(4-hydroxybutyl)-2-pyridyl]pentanol, 4-[3,5-di(2-methoxypropyl)-2-pyridyl]-2-methylbutanol, 2[2-(2-methoxybutyl)-5-(1-methoxypropyl)-3-pyridyl]butanol, 5-amino-4-methyl-1-pentanol, 5-imino-2-methyl-1-pentanamine, 5-amino-2-methyl-1-pentanol, 5-imino-4-methyl-1-pentanamine and 2-butyl-4,5-dipropylpyridine, wherein the weight ratio of component a) to component b) is at least about 99 to 1. The epsilon caprolactam compositions are useful in the preparation of nylon 6.

Abstract translation: 本发明涉及一种令人满意的（a）ε-己内酰胺和（b）一种或多种5- [4,5-二（3-羧丙基）-2-吡啶基]戊酸或其盐或酰胺的组合物，4- [ 2-（2-羧基丙基）-2-吡啶基] -2-甲基丁酸或盐或酰胺，2- [2-（2-羧基丁基）-5-（1-羧基丙基）-4-吡啶基]丁酸或盐 或酰胺，5- [3,5-二（3-羧丙基）-2-吡啶基]戊酸或盐或酰胺，4- [3,5-二（2-羧丙基）-2-吡啶基] -2-甲基丁酸 酸或盐或酰胺，2- [2-（2-羧丁基）-5-（1-羧基丙基）-3-吡啶基]丁酸或盐或酰胺，5-氨基-4-甲基戊酰胺，4-氨基-3- 乙基丁酰胺，5- [4,5-二（4-羟基丁基）-2-吡啶基]戊醇，4- [4,5-二（2-甲氧基丙基）-2-吡啶基] -2-甲基丁醇，2- [2- （2-甲氧基丁基）-5-（1-甲氧基丙基）-4-吡啶基]丁醇，5- [3,5-二（4-羟基丁基）-2-吡啶基]戊醇，4- [3,5-二 - 甲氧基丙基）-2-吡啶基] -2-甲基丁醇，2 [2-（2-甲氧基丁基）-5-（1-甲氧基丙基）-3-吡啶基]丁醇，5-氨基-4-甲基-1-戊醇，5 - 亚氨基-2-甲基-1- pentanamin e，5-氨基-2-甲基-1-戊醇，5-亚氨基-4-甲基-1-戊胺和2-丁基-4,5-二丙基吡啶，其中组分a）与组分b）的重量比为 至少约99-1。ε-己内酰胺组合物可用于制备尼龙6。

公开(公告)号：WO2012036825A1

公开(公告)日：2012-03-22

申请号：PCT/US2011/047843

申请日：2011-08-16

Applicant: EXXONMOBIL CHEMICAL PATENTS INC. ,  DAKKA, Jihad, M. ,  BENITEZ, Francisco, M. ,  PATEL, Bryan, A. ,  MOZELESKI, Edmund, J.

Inventor： DAKKA, Jihad, M. ,  BENITEZ, Francisco, M. ,  PATEL, Bryan, A. ,  MOZELESKI, Edmund, J.

IPC: C07C409/14 ,  C07C2/74 ,  C07C13/28 ,  C07C37/08 ,  C07C39/04 ,  C07C45/53 ,  C07C49/403

CPC classification number: C07C409/14 ,  C07C2/74 ,  C07C37/08 ,  C07C45/32 ,  C07C45/53 ,  C07C51/00 ,  C07C249/04 ,  C07C407/00 ,  C07C2601/14 ,  C07D201/02 ,  C08G69/00 ,  Y02P20/52 ,  C07C13/28 ,  C07C49/403 ,  C07C39/04

Abstract: In a process for oxidizing a feed comprising cyclohexylbenzene, the feed is contacted with oxygen and an oxidation catalyst in a plurality of reaction zones connected in series, the contacting being conducted under conditions being effective to oxidize part of the cyclohexylbenzene in the feed to cyclohexylbenzene hydroperoxide in each reaction zone. At least one of the plurality of reaction zones has a reaction condition that is different from another of the plurality of reaction zones. The different reaction conditions may include one or more of (a) a progressively decreasing temperature and (b) a progressively increasing oxidation catalyst concentration as the feed flows from one reaction zone to subsequent reaction zones in the series.

Abstract translation: 在用于氧化包含环己基苯的进料的方法中，将进料与串联连接的多个反应区中的氧和氧化催化剂接触，在有效地将进料中环己基苯的一部分氧化成环己基苯氢过氧化物的条件下进行 在每个反应区。 多个反应区中的至少一个具有与多个反应区中的另一个不同的反应条件。 不同的反应条件可以包括（a）逐渐降低的温度和（b）随着进料从一个反应区流向该系列中的后续反应区的逐渐增加的氧化催化剂浓度中的一个或多个。

公开(公告)号：WO2008103366A2

公开(公告)日：2008-08-28

申请号：PCT/US2008002202

申请日：2008-02-20

Applicant: UNIV MICHIGAN STATE ,  FROST JOHN W

Inventor： FROST JOHN W

IPC: C07D201/02 ,  C07D201/16

CPC classification number: C07D201/00 ,  C07D201/02 ,  C07D201/08 ,  Y02P20/52

Abstract: Catalytic processes for preparing caprolactam, pipecolinic acid, and their derivatives, from lysine or alpha-amino-epsilon-caprolactam starting materials, and products produced thereby. A process for preparing caprolactam or a derivative thereof, the process comprising contacting a reactant comprising lysine or alpha aminocaprolactam with a catalyst and a gas comprising hydrogen gas, in the presence of a solvent. The catalyst may be provided on a support material, such as a transition metal.

Abstract translation: 由赖氨酸或α-氨基-ε-己内酰胺原料制备己内酰胺，哌可林酸及其衍生物的催化方法，以及由此制得的产物。 一种制备己内酰胺或其衍生物的方法，所述方法包括使包含赖氨酸或α-氨基己内酰胺的反应物与催化剂和包含氢气的气体在溶剂存在下接触。 催化剂可以提供在载体材料如过渡金属上。

公开(公告)号：WO1993017787A1

公开(公告)日：1993-09-16

申请号：PCT/US1993001397

申请日：1993-02-18

Applicant: ISP INVESTMENTS INC.

Inventor： ISP INVESTMENTS INC. ,  ANDERSON, Lowell, R. ,  CHAUDHURI, Ratan, K. ,  LOGIN, Robert, B. ,  DE THOMAS, Waldo

IPC: B01J23/44

CPC classification number: C07D201/02 ,  B01J23/8926 ,  B01J23/8986 ,  C07D207/267 ,  C07D211/76 ,  C07D223/10

Abstract: A catalyst and method for producing N-substituted pyrrolidones utilizes a copper-palladium catalyst disposed on a support and mixed with a desired alcohol and 2-pyrrolidone. A reaction is undertaken under a hydrogen atmosphere, preferably at 50 to 1000 psig, and at a temperature ranging up to 400 DEG C. Utilizing a copper-palladium catalyst provides superior results in selectivity and yield over previous catalysts.

Abstract translation: 催化剂和制备N-取代的吡咯烷酮的方法利用设置在载体上的铜 - 钯催化剂并与所需的醇和2-吡咯烷酮混合。 反应在氢气氛下进行，优选在50-1000psig，温度范围达到400℃。使用铜 - 钯催化剂，提供优于先前催化剂的选择性和产率的优异结果。

公开(公告)号：WO2008103366A3

公开(公告)日：2008-12-24

申请号：PCT/US2008002202

申请日：2008-02-20

Applicant: UNIV MICHIGAN STATE ,  FROST JOHN W

Inventor： FROST JOHN W

IPC: C07D201/00 ,  C07D201/02 ,  C07D201/08

CPC classification number: C07D201/00 ,  C07D201/02 ,  C07D201/08 ,  Y02P20/52

Abstract: Catalytic processes for preparing caprolactam, pipecolinic acid, and their derivatives, from lysine or alpha-amino-epsilon-caprolactam starting materials, and products produced thereby. A process for preparing caprolactam or a derivative thereof, the process comprising contacting a reactant comprising lysine or alpha aminocaprolactam with a catalyst and a gas comprising hydrogen gas, in the presence of a solvent. The catalyst may be provided on a support material, such as a transition metal.

Abstract translation: 从赖氨酸或α-氨基-ε-己内酰胺起始原料制备己内酰胺，哌可啶酸及其衍生物的催化方法，以及由此产生的产物。 一种制备己内酰胺或其衍生物的方法，该方法包括在溶剂存在下使包含赖氨酸或α-氨基己内酰胺的反应物与催化剂和包含氢气的气体接触。 催化剂可以设置在载体材料如过渡金属上。

公开(公告)号：WO00017168A1

公开(公告)日：2000-03-30

申请号：PCT/EP1999/006690

申请日：1999-09-10

IPC: C07D223/04 ,  C07B61/00 ,  C07D201/02 ,  C07D223/10 ,  C07D295/023 ,  C07D295/02

CPC classification number: C07D201/02 ,  C07D295/023

Abstract: The invention relates to a method for the joint production of a cyclic lactam and a cyclic amine by reacting an aliphatic alpha, omega diamine in the gas phase with water and in the presence of a heterogeneous catalyst.

Abstract translation: 一种用于环状内酰胺的制备联合并且通过在非均相催化剂的存在下在气相中的脂族α，ω-二胺与水反应的环状胺的过程。

公开(公告)号：WO98046565A1

公开(公告)日：1998-10-22

申请号：PCT/US1998/007358

申请日：1998-04-14

IPC: B01J31/24 ,  C07B61/00 ,  C07D201/02 ,  C07D201/08 ,  C07D223/10 ,  C08G69/02 ,  C08G69/14 ,  C08G69/36

CPC classification number: C07D201/02 ,  C07D201/08 ,  C08G69/02 ,  C08G69/14 ,  C08G69/36 ,  Y02P20/582

Abstract: This invention relates in part to processes for producing one or more substituted or unsubstituted epsilon caprolactams, e.g., epsilon caprolactam, which comprises: (a) subjecting one or more substituted or unsubstituted alkadienes to hydroxycarbonylation in the presence of a hydroxycarbonylation catalyst, e.g., a metal-organophosphorus ligand complex catalyst, and neutralization with a base to produce one or more substituted or unsubstituted pentenoic acid salts; (b) subjecting said one or more substituted or unsubstituted pentenoic acid salts to hydroformylation in the presence of a hydroformylation catalyst, e.g., a metal-organophosphorus ligand complex catalyst, to produce one or more substituted or unsubstituted formylvaleric acid salts and/or one or more substituted or unsubstituted epsilon caprolactam precursors; and (c) subjecting said one or more substituted or unsubstituted formylvaleric acid salts and/or said one or more substituted or unsubstituted epsilon caprolactam precursors to reductive amination in the presence of a reductive amination catalyst and cyclization optionally in the presence of a cyclization catalyst to produce said one or more substituted or unsubstituted epsilon caprolactams. This invention also relates in part to reaction mixtures containing one or more substituted or unsubstituted epsilon caprolactams as the principal product(s) of reaction.

Abstract translation: 本发明部分地涉及用于制备一种或多种取代或未取代的ε-己内酰胺（例如ε-己内酰胺）的方法，其包括：（a）在羟基羰基化催化剂存在下使一种或多种取代或未取代的烷撑二醇进行羟基羰基化， 金属有机磷配体络合物催化剂，并用碱中和以产生一种或多种取代或未取代的戊烯酸盐; （b）在加氢甲酰化催化剂例如金属 - 有机磷配体络合物催化剂的存在下，使所述一种或多种取代或未取代的戊烯酸盐进行加氢甲酰化，以产生一种或多种取代或未取代的甲酰基戊酸盐和/或一种或多种 更多取代或未取代的ε己内酰胺前体; 和（c）在还原胺化催化剂存在下使所述一种或多种取代或未取代的甲酰基戊酸盐和/或所述一种或多种取代或未取代的己内酰胺前体进行还原胺化，任选地在环化催化剂存在下进行环化， 产生所述一种或多种取代或未取代的ε己内酰胺。 本发明还部分涉及含有一种或多种取代或未取代的ε-己内酰胺作为反应主要产物的反应混合物。

公开(公告)号：WO1997003953A1

公开(公告)日：1997-02-06

申请号：PCT/EP1996002954

申请日：1996-07-05

Applicant: HAFSLUND NYCOMED PHARMA AG ,  BLASCHKE, Heinz ,  KREMMINGER, Peter ,  HARTMANN, Michael ,  FELLIER, Harald ,  BERG, Jörg ,  CHRISTOPH, Thomas ,  ROVENSZKY, Franz ,  STIMMEDER, Dagmar

Inventor： HAFSLUND NYCOMED PHARMA AG

IPC: C07C311/39

CPC classification number: C07C311/39 ,  C07C311/40 ,  C07C311/42 ,  C07C311/44 ,  C07C311/48 ,  C07C311/51 ,  C07C323/67 ,  C07D201/02 ,  C07D205/04 ,  C07D213/65 ,  C07D213/70 ,  C07D213/75 ,  C07D233/42 ,  C07D275/06 ,  C07D285/125 ,  C07D307/64 ,  C07D333/34

Abstract: Compounds of the formula (I) in which A is oxygen, sulphur or NH; B is a group of the formula (IIa) or (IIb); and the other variables have the meaning given in claim 1, may be used as inhibitors of the enzyme cyclo-oxygenase II.

Abstract translation: 是指式（I），其中A是氧，硫或NH的化合物，B是一组式（IIa）或（IIb）中的; 并且其它变量具有权利要求1给出的相同含义; 是作为酶环氧合酶II的抑制剂是有用的。