- Patent Title: RETROVIRAL PROTEASE INHIBITOR (2S,3S,5S)-5-(N-(N-((N-METHYL-N-((2-ISOPROPYL-4- THIAZOLYL)METHYL)AMINO)CARBONYL)VALINYL)AMINO)- 2-(N-((5-THIAZOLYL)METHOXYCARBONYL)AMINO)-1, 6-DIPHENYL-3-HYDROXYHEXANE
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Application No.: CA2135890Application Date: 1993-12-16
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Publication No.: CA2135890CPublication Date: 1996-08-27
- Inventor: KEMPF DALE J , NORBECK DANIEL W , SHAM HING LEUNG , ZHAO CHEN
- Applicant: ABBOTT LAB
- Assignee: ABBOTT LAB
- Current Assignee: ABBOTT LAB
- Priority: US99811492 1992-12-29; US15858793 1993-12-02
- Main IPC: C07D275/02
- IPC: C07D275/02 ; A61K31/395 ; A61K31/415 ; A61K31/4164 ; A61K31/42 ; A61K31/421 ; A61K31/422 ; A61K31/425 ; A61K31/426 ; A61K31/427 ; A61K31/535 ; A61K31/5375 ; A61K31/5377 ; A61K31/54 ; A61K38/00 ; A61K45/06 ; A61P31/12 ; A61P31/18 ; A61P35/00 ; A61P35/02 ; A61P37/04 ; A61P43/00 ; C07C33/46 ; C07C43/164 ; C07C43/174 ; C07C43/205 ; C07C43/215 ; C07C43/23 ; C07C43/30 ; C07C43/315 ; C07C45/00 ; C07C45/29 ; C07C45/56 ; C07C45/62 ; C07C45/67 ; C07C45/74 ; C07C53/134 ; C07C69/34 ; C07C69/65 ; C07C69/732 ; C07C211/27 ; C07C215/18 ; C07C215/20 ; C07C215/28 ; C07C229/08 ; C07C229/26 ; C07C229/34 ; C07C233/36 ; C07C233/40 ; C07C235/10 ; C07C235/12 ; C07C235/34 ; C07C235/78 ; C07C237/10 ; C07C237/20 ; C07C237/22 ; C07C239/10 ; C07C239/18 ; C07C239/20 ; C07C247/10 ; C07C251/40 ; C07C271/20 ; C07C271/22 ; C07C271/34 ; C07C275/16 ; C07C275/24 ; C07C311/03 ; C07C311/13 ; C07C311/18 ; C07C317/10 ; C07C317/28 ; C07C317/44 ; C07C323/12 ; C07C323/25 ; C07C381/00 ; C07D20060101 ; C07D213/26 ; C07D213/30 ; C07D213/34 ; C07D213/40 ; C07D213/54 ; C07D213/56 ; C07D213/61 ; C07D213/75 ; C07D233/54 ; C07D233/84 ; C07D235/10 ; C07D235/14 ; C07D235/16 ; C07D239/26 ; C07D241/12 ; C07D261/06 ; C07D261/08 ; C07D263/24 ; C07D263/30 ; C07D263/32 ; C07D263/48 ; C07D265/30 ; C07D277/22 ; C07D277/24 ; C07D277/28 ; C07D277/30 ; C07D277/32 ; C07D277/34 ; C07D277/36 ; C07D277/40 ; C07D277/42 ; C07D277/56 ; C07D295/13 ; C07D295/205 ; C07D295/215 ; C07D303/36 ; C07D307/42 ; C07D333/16 ; C07D401/12 ; C07D413/12 ; C07D413/14 ; C07D417/12 ; C07D417/14 ; C07D521/00 ; C07F5/02 ; C07F5/04 ; C07K5/06 ; C07K5/065
Abstract:
A retroviral protease inhibiting compound of formula (A) wherein R1 is 2-isopropylthiazol-4-yl; n is 1; R2 is hydrogen; R3 is isopropyl; R4 and R4a are phenyl; R6 is hydrogen; R7 is thiazol-5-yl; X is hydrogen and Y is -OH; and Z is -N(CH3)-; or a pharmaceutically acceptable salt, ester or prodrug thereof.
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