Invention Grant
- Patent Title: Fusion proteins, recombinant bacteria, and methods for using recombinant bacteria
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Application No.: US15842062Application Date: 2017-12-14
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Publication No.: US10407472B2Publication Date: 2019-09-10
- Inventor: Brian Thompson , Ashley Siegel
- Applicant: Spogen Biotech Inc.
- Applicant Address: US MO St. Louis
- Assignee: Spogen Biotech Inc.
- Current Assignee: Spogen Biotech Inc.
- Current Assignee Address: US MO St. Louis
- Agency: Stinson LLP
- Main IPC: C07K14/32
- IPC: C07K14/32 ; A01N37/44 ; A61L2/18 ; C09K8/62 ; E21B43/16 ; A23K20/147 ; C12P21/02 ; C12N1/20 ; C12N3/00 ; C12N15/62 ; C12N15/75 ; A01N63/02 ; C02F3/34 ; A23K10/18 ; A61K39/00 ; C02F103/00 ; C02F103/06 ; C02F103/10 ; C02F103/14 ; C02F103/16 ; C02F103/26 ; C02F103/28 ; C02F101/10 ; C02F101/30

Abstract:
Fusion proteins containing a targeting sequence, an exosporium protein, or an exosporium protein fragment that targets the fusion protein to the exosporium of a Bacillus cereus family member are provided. Recombinant Bacillus cereus family members expressing such fusion proteins are also provided. Genetically inactivated Bacillus cereus family members and recombinant Bacillus cereus family members that overexpress exosporium proteins are also provided. Seeds coated with the recombinant Bacillus cereus family members and methods for using the recombinant Bacillus cereus family members (e.g., for stimulating plant growth) are also provided. Various modifications of the recombinant Bacillus cereus family members that express the fusion proteins are further provided. Fusion proteins comprising a spore coat protein and a protein or peptide of interest, recombinant bacteria that express such fusion proteins, seeds coated with such recombinant bacteria, and methods for using such recombinant bacteria (e.g., for stimulating plant growth) are also provided.
Public/Granted literature
- US20180099999A1 FUSION PROTEINS, RECOMBINANT BACTERIA, AND METHODS FOR USING RECOMBINANT BACTERIA Public/Granted day:2018-04-12
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