公开(公告)号：KR101371194B1

公开(公告)日：2014-03-12

申请号：KR1020120025594

申请日：2012-03-13

Applicant: 대구가톨릭대학교산학협력단 ,  (주)에스.앤.디

Inventor： 최상원 ,  김은옥 ,  조성희 ,  박은정

IPC: A61K31/404 ,  A61K36/815 ,  A61P3/00

Abstract: 본 발명은 구기자 뿌리껍질인 지골피(
Lycii Cortex Radicis , LCR)로부터 유래한 티라민 유도체(CT, FT)의 항콜레스테롤 효능에 관한 것으로, 지골피 유래의 티라민 유도체는 HMG-CoA 환원효소와 ACAT의 활성을 저해하고, 동물실험을 통하여 혈청 총콜레스테롤 감소효과 뿐만 아니라, 특히 LCR 페놀릭아마이드 FT는 잇꽃종자유래의 FS(
N- feruloylserotonin) 수준의 상기 효소저해 효과가 있고 페놀릭아마이드를 포함하는 LCR 추출물은 저농도에서도 잇꽃종자추출물 유래의 serotonin보다 혈청 콜레스테롤 수준을 감소시키는 뛰어난 효과가 있다

公开(公告)号：KR1020130104240A

公开(公告)日：2013-09-25

申请号：KR1020120025594

申请日：2012-03-13

Applicant: 대구가톨릭대학교산학협력단 ,  (주)에스.앤.디

Inventor： 최상원 ,  김은옥 ,  조성희 ,  박은정

IPC: A61K31/404 ,  A61K36/815 ,  A61P3/00

CPC classification number: A61K36/815 ,  A23V2200/326 ,  A61K2236/333

Abstract: PURPOSE: An anticholesterol composition is provided to suppress the activities of HMG-CoA reductase and acyl-CoA:cholesterol acyltransferase (ACAT) and to lower cholesterol in serum using a Lycii radicis cortex-derived tyramine derivative, thereby preventing hyperlipidemia. CONSTITUTION: A method for preparing an anticholesterol tyramine derivative comprises the steps of: extracting Lycii radicis cortex powder with an ethanol solution and filtering the extract; concentrating the extract by compression; and performing Sep-Pak C18 cartridges column chromatography. The derivative is trans-N-p-coumaroyltyramine (CT) or trans-N-feruloyltyramine (FT). A functional food composition for anticholesterol and antioxidative effects contains the tyramine derivative as an active ingredient.

Abstract translation: 目的：提供一种抗胆固醇组合物，以抑制HMG-CoA还原酶和酰基辅酶A：胆固醇酰基转移酶（ACAT）的活性，并使用雷公藤皮质衍生的酪胺衍生物降低血清中的胆固醇，从而预防高脂血症。 构成：制备抗胆固醇酪胺衍生物的方法，包括以下步骤：用乙醇溶液提取李子皮质粉末并过滤提取物; 通过压缩浓缩提取物; 并进行Sep-Pak C18柱色谱。 衍生物是反式-N-对 - 芳香酰酪氨酸（CT）或反式N-阿魏酰酪胺（FT）。 用于抗胆固醇和抗氧化作用的功能性食品组合物含有酪胺衍生物作为活性成分。

公开(公告)号：WO2017159912A1

公开(公告)日：2017-09-21

申请号：PCT/KR2016/003209

申请日：2016-03-29

Applicant: 대구가톨릭대학교산학협력단

Inventor： 최상원 ,  김은정 ,  안은영 ,  전영희

IPC: A23L1/30 ,  A61K36/605 ,  A61K9/20 ,  A61K9/48

CPC classification number: A61K9/20 ,  A61K9/48 ,  A61K36/605

Abstract: 본 발명은 상지 열수추출물 및 상지 지표성분인 ORT를 함유하는 항당뇨 조성물에 관한 것으로 Streptozotocin 유도 당뇨쥐에 투여하여 상백피 열수추출물과 비교했을 때 소장 이당류분해효소 활성을 억제하여 혈당을 낮추고 혈장 내 지질 개선 효과가 더 뛰어날 뿐만 아니라 간 조직 내로 포도당 유입을 증가시키고 글리코겐 합성을 증가시켜 혈당강하 효과를 확인함으로써 상지 열수추출물 및 상지 지표성분인 ORT를 함유하는 당뇨 예방 및 치료 기능성 의약품 및 식품 조성물로 이용할 수 있는 뛰어난 효과가 있다.

Abstract translation:

抑制本发明的上肢热水提取物和小肠二糖裂合酶活性的上肢表面组分当给予链脲佐菌素诱导的糖尿病大鼠涉及含有ORT抗糖尿病组合物与森皮质热水提取物相比 通过增加葡萄糖流入肝脏组织以降低血液葡萄糖血浆以及脂质更通过验证含有的官能上肢热水提取物和ORT糖尿病预防上肢表面组分和治疗的降血糖作用练成改进和增加的糖原合成 有很好的效果，可用于药品和食品组合物。

公开(公告)号：KR1020130025422A

公开(公告)日：2013-03-11

申请号：KR1020130010581

申请日：2013-01-30

Applicant: (주)에스.앤.디

Inventor： 여경목 ,  최상원 ,  권상오 ,  김복남 ,  김동희

IPC: A61K31/4045 ,  A61K31/135 ,  A61K36/286 ,  A61K36/906

CPC classification number: A61K31/4045 ,  A61K31/12 ,  A61K31/165 ,  A61K36/286 ,  A61K36/906 ,  A61K2300/00

Abstract: PURPOSE: A complex crude drug extract containing a phenylamide compound is provided to prevent and treat hyperlipidemia without side effects and toxicity. CONSTITUTION: A complex crude drug extract for treating hyperlipidemia contains a serotonin derivative, a tyramine derivative, and gingerol in a weight ratio of 5:1:1. The serotonin derivative is N-(p-coumaroyl)serotonin(CS), N-feruloylserotonin(FS), or a mixture thereof. The tyramine derivative is dihydro-N-cafferoyltyramine(DCT), trans-N-cafferoyltyramine(t-CT), or a mixture thereof. Gingerol includes 6-gingerol, 8-gingerol, or a mixture thereof. [Reference numerals] (AA) Ginger + Safflower seed; (BB) Ginger 1 : Safflower seed B8; (CC) Ginger 1 : Safflower seed B4; (DD) Ginger 1 : Safflower seed B2; (EE) Ginger 1 : Safflower seed B1; (FF) Ginger 2 : Safflower seed B1; (GG) Ginger 4 : Safflower seed B1; (HH) Ginger 8 : Safflower seed B1; (II) Ginger 1 : Safflower seed A1; (JJ) Ginger 2 : Safflower seed A1; (KK) Ginger 4 : Safflower seed A1; (LL) Ginger 8 : Safflower seed A1

Abstract translation: 目的：提供含有苯酰胺化合物的复合生物药物提取物，用于预防和治疗高脂血症，无副作用和毒性。 构成：用于治疗高脂血症的复杂生药提取物含有重量比为5:1:1的5-羟色胺衍生物，酪胺衍生物和姜油。 5-羟色胺衍生物是N-（对 - 香豆酰基）5-羟色胺（CS），N-亚铁血清素（FS）或其混合物。 酪胺衍生物是二氢-N-咖啡酰基酪氨酸（DCT），反式N-咖啡酰酪胺（t-CT）或其混合物。 姜醇包括6-姜醇，8-姜醇或其混合物。 （标号）（AA）姜+红花种子; （BB）姜1：红花种子B8; （CC）姜1：红花籽B4; （DD）姜1：红花籽B2; （EE）姜1：红花籽B1; （FF）姜2：红花籽B1; （GG）姜4：红花籽B1; （HH）姜8：红花籽B1; （二）姜1：红花籽A1; （JJ）姜2：红花籽A1; （KK）姜4：红花籽A1; （LL）姜8：红花籽A1

公开(公告)号：KR101335575B1

公开(公告)日：2013-12-02

申请号：KR1020130010580

申请日：2013-01-30

Applicant: (주)에스.앤.디

Inventor： 여경목 ,  최상원 ,  권상오 ,  김복남 ,  김동희

IPC: A61K31/4045 ,  A61K31/135 ,  A61K36/286 ,  A61K36/906

Abstract: 본 발명은 고지혈증 치료 및 예방관련한 HMG-CoR 저해효과와 ACAT저해 효과를 나타내는 페닐아마이드 화합물을 유효성분으로 하는 고지혈증 치료용 복합 생약 추출물에 관한 것으로, 상세하게는 천연물인 홍화씨 생강 복합 추출물로 구성된 고지혈증 치료용 조성물에 관한 것이다. 또한 본 발명은 각 추출물로부터 인체에 부작용 또는 독성 등의 우려가 없고 고지혈증 치료 및 예방을 목적으로 하는 페닐아마이드 물질의 제조방법에 관한 것이다.

Abstract translation: 本发明涉及一种用于治疗高脂血症的组合的草药提取物来表示高脂血症治疗和预防相关的HMG-COR抑制活性和ACAT抑制活性作为活性成分，尤其是由天然产物红花姜合并的萃取物的高脂血症治疗苯基酰胺化合物 ＆lt; 本发明还涉及用于制备苯酰胺材料用于治疗和预防高血脂的目的的过程中，有没有从各提取物等副作用或毒性对人体可能性。

公开(公告)号：KR101335576B1

公开(公告)日：2013-12-02

申请号：KR1020130010581

申请日：2013-01-30

Applicant: (주)에스.앤.디

Inventor： 여경목 ,  최상원 ,  권상오 ,  김복남 ,  김동희

IPC: A61K31/4045 ,  A61K31/135 ,  A61K36/286 ,  A61K36/906

Abstract: 본 발명은 고지혈증 치료 및 예방관련한 HMG-CoR 저해효과와 ACAT저해 효과를 나타내는 페닐아마이드 화합물을 유효성분으로 하는 고지혈증 치료용 복합 생약 추출물에 관한 것으로, 상세하게는 천연물인 홍화씨 생강 복합 추출물로 구성된 고지혈증 치료용 조성물에 관한 것이다. 또한 본 발명은 각 추출물로부터 인체에 부작용 또는 독성 등의 우려가 없고 고지혈증 치료 및 예방을 목적으로 하는 페닐아마이드 물질의 제조방법에 관한 것이다.

公开(公告)号：KR1020130025421A

公开(公告)日：2013-03-11

申请号：KR1020130010580

申请日：2013-01-30

Applicant: (주)에스.앤.디

Inventor： 여경목 ,  최상원 ,  권상오 ,  김복남 ,  김동희

IPC: A61K31/4045 ,  A61K31/135 ,  A61K36/286 ,  A61K36/906

CPC classification number: A61K31/4045 ,  A61K31/165 ,  A61K36/286 ,  A61K36/906 ,  A61K2300/00

Abstract: PURPOSE: A complex crude drug extract containing a phenylamide compound is provided to reduce side effects and toxicity, and to treat hyperlipidemia. CONSTITUTION: A complex crude drug extract for treating hyperlipidemia contains a serotonin derivative and a tyramine derivative in a weight ratio of 4:1. The serotonin derivative is N-(p-coumaroyl)serotonin(CS), N-feruloylserotonin(FS), or a mixture thereof. The tyramine derivative is dihydro-N-caffeoyltyramine(DCT), trans-N-caffeoyltyramine(t-CT), or a mixture thereof. [Reference numerals] (AA) Ginger + Safflower seed; (BB) Ginger 1 : Safflower seed B8; (CC) Ginger 1 : Safflower seed B4; (DD) Ginger 1 : Safflower seed B2; (EE) Ginger 1 : Safflower seed B1; (FF) Ginger 2 : Safflower seed B1; (GG) Ginger 4 : Safflower seed B1; (HH) Ginger 8 : Safflower seed B1; (II) Ginger 1 : Safflower seed A1; (JJ) Ginger 2 : Safflower seed A1; (KK) Ginger 4 : Safflower seed A1; (LL) Ginger 8 : Safflower seed A1

Abstract translation: 目的：提供含有苯酰胺化合物的复合生物药物提取物，以减少副作用和毒性，并治疗高脂血症。 构成：用于治疗高脂血症的复杂生药提取物含有重量比为4:1的5-羟色胺衍生物和酪胺衍生物。 5-羟色胺衍生物是N-（对 - 香豆酰基）5-羟色胺（CS），N-亚铁血清素（FS）或其混合物。 酪胺衍生物是二氢-N-咖啡酰基酪氨酸（DCT），反式N-咖啡酰酪胺（t-CT）或其混合物。 （标号）（AA）姜+红花种子; （BB）姜1：红花种子B8; （CC）姜1：红花籽B4; （DD）姜1：红花籽B2; （EE）姜1：红花籽B1; （FF）姜2：红花籽B1; （GG）姜4：红花籽B1; （HH）姜8：红花籽B1; （二）姜1：红花籽A1; （JJ）姜2：红花籽A1; （KK）姜4：红花籽A1; （LL）姜8：红花籽A1

公开(公告)号：KR1020120115060A

公开(公告)日：2012-10-17

申请号：KR1020110071839

申请日：2011-07-20

Applicant: (주)에스.앤.디

Inventor： 여경목 ,  최상원 ,  권상오 ,  김복남 ,  김동희

IPC: A61K36/286 ,  A61K36/906 ,  A61P3/06

Abstract: PURPOSE: A complex crude drug extract for treating hyperlipidemia which contains phenyl amide compound is provided to show HMG-CoR inhibition effects and ACAT inhibition effects related to treat and prevent the hyperlipidemia. CONSTITUTION: A complex crude drug extract for treating hyperlipidemia is composed of multiple extract of safflower seed and ginger. The mixing ratio of the safflower seed to ginger is 4:1 in the weight ratio. The Lycii Radicis Cortex extract is additionally added to the extract. The mixing ration of the safflower seed, ginger extract, and the Lycii Radicis Cortex extract is 5:1:1 in the weight ratio. The complex crude drug extract for treating hyperlipidemia is composed of serotonin derivative and tyramine derivative. The mixing ratio of serotonin derivative to the tyramine derivative is 4: 1 in the weight ratio. The serotonin derivative is a mixture of N-(p-coumaroyl) serotonin(CS), N- feruloylserotonin(FS), or a mixture thereof. [Reference numerals] (AA) Ginger+safflower seed; (BB) Ginger 1 : Safflower seed B3; (CC) Ginger 1 : Safflower seed B4; (DD) Ginger 1 : Safflower seed B2; (EE) Ginger 1 : Safflower seed B1; (FF) Ginger 2 : Safflower seed B1; (GG) Ginger 4 : Safflower seed B1; (HH) Ginger 8 : Safflower seed B1; (II) Ginger 1 : Safflower seed A1; (JJ) Ginger 2 : Safflower seed A1; (KK) Ginger 4 : Safflower seed A1; (LL) Ginger 8 : Safflower seed A1

Abstract translation: 目的：提供一种用于治疗含有苯酰胺化合物的高脂血症的复合生药提取物，以显示与治疗和预防高脂血症相关的HMG-CoR抑制作用和ACAT抑制作用。 构成：用于治疗高脂血症的复方生药提取物由红花种子和姜的多次提取物组成。 红花种子与姜的混合比例为4：1。 提取物中还加入Lycii Radicis Cortex提取物。 红花种子，姜提取物和堇菜提取物的混合比例为5：1：1。 用于治疗高脂血症的复方生药提取物由5-羟色胺衍生物和酪胺衍生物组成。 5-羟色胺衍生物与酪胺衍生物的混合比例为重量比为4:1。 5-羟色胺衍生物是N-（对 - 香豆酰基）5-羟色胺（CS），N-阿魏酰基血清素（FS）或其混合物的混合物。 （标号）（AA）姜+红花种子; （BB）姜1：红花籽B3; （CC）姜1：红花籽B4; （DD）姜1：红花籽B2; （EE）姜1：红花籽B1; （FF）姜2：红花籽B1; （GG）姜4：红花籽B1; （HH）姜8：红花籽B1; （二）姜1：红花籽A1; （JJ）姜2：红花籽A1; （KK）姜4：红花籽A1; （LL）姜8：红花籽A1

公开(公告)号：KR1020170108222A

公开(公告)日：2017-09-27

申请号：KR1020160031775

申请日：2016-03-17

Applicant: 대구가톨릭대학교산학협력단

Inventor： 최상원 ,  김은정 ,  안은영 ,  전영희

IPC: A23L1/30 ,  A61K36/605 ,  A61K9/20 ,  A61K9/48

CPC classification number: A61K9/20 ,  A61K9/48 ,  A61K36/605

Abstract: 본발명은상지열수추출물및 상지지표성분인 ORT를함유하는항당뇨조성물에관한것으로 Streptozotocin 유도당뇨쥐에투여하여상백피열수추출물과비교했을때 소장이당류분해효소활성을억제하여혈당을낮추고혈장내 지질개선효과가더 뛰어날뿐만아니라간 조직내로포도당유입을증가시키고글리코겐합성을증가시켜혈당강하효과를확인함으로써상지열수추출물및 상지지표성분인 ORT를함유하는당뇨예방및 치료기능성의약품및 식품조성물로이용할수 있는뛰어난효과가있다.

Abstract translation: 本发明上肢热水提取物和链脲佐菌素通过向小鼠施用诱导的糖尿病桑热水提取物的脂质相比，通过在含有ORT上肢指示器部件的抗糖尿病组合物抑制小肠二糖分解酶的活性提高了血浆降低血糖 效果更练成不仅增加了葡萄糖流入肝组织以及与增加的糖原合成通过检查血糖降低作用，这将能够使用它作为糖尿病预防和治疗功能的药物和含有所述上肢，所述热水提取物和上肢表面部件ORT的食物组合物 它有很好的效果。

公开(公告)号：KR1020130093372A

公开(公告)日：2013-08-22

申请号：KR1020120014928

申请日：2012-02-14

Applicant: 대구가톨릭대학교산학협력단 ,  최상원

Inventor： 최상원 ,  김은옥 ,  임현희

IPC: A61K36/605 ,  A61K36/60 ,  A61K31/045 ,  A61K31/05

CPC classification number: A61K8/97 ,  A61K36/605 ,  A61K2236/10 ,  A61K2236/19 ,  A61K2236/33 ,  A61Q19/02 ,  A61Q19/08 ,  Y10S514/844 ,  Y10S514/857

Abstract: PURPOSE: A method for preparing a mulberry branch extract is provided to produce a large amount of purified powder containing oxyresveratrol with anti-inflammatory and antiaging functions and to use trans-rasveratrol and moracin as a novel material for functional foods and cosmetic products. CONSTITUTION: A method for preparing a mulberry branch extract containing oxyresveratrol comprises the steps of: steaming mulberry branches for one hour and drying; adding 650 kg of a 75-95% ethanol solution to 100 kg of the dried mulberry branches and extracting by ultrasonic wave at 40-50°C for 12 hours; concentrating the extract by reduced pressure; dissolving the concentrate in a 80% ethanol solution and incubating at room temperature; removing precipitate, adding normal-hexane, and fractioning; removing an upper layer oil and concentrating the lower layer; adding a 20% ethanol solution to the defatted ethanol extract of mulberry branches and suspending; treating the defatted ethanol extract with 10% pectinase and hydrolyzing at 30-40°C for 12 hours to obtain a hydrolysate; fractioning the hydrolysate with an ethyl acetate solvent and concentrating the upper layer by reduced pressure; dissolving the concentrate using the 20% ethanol solution and adsorbing onto diaion HP-20 adsorption ion exchange column; washing the resultant with the 20% ethanol solution; and eluting the resultant with a 40% ethanol solution and concentrating. [Reference numerals] (AA) Dried mulberry branches(100kg); (BB) CNCNF(650kg, 80% ethanol solution, ultrasonic extractor, 50°C, 12 hours, twice); (CC) Filter; (DD) Filtered liquid; (EE, LL) Concentrate by reduced pressure; (FF) Ethanol extract of the mulberry branches(10kg); (GG) Re-dissolve(50kg, ethanol solution); (HH) Incubate day and night; (II) Supernatant; (JJ) Defatting(100kg, normal-hexane); (KK) Lower layer; (MM) Defatted ethanol extract of mulberry branches(8.5kg); (NN) Suspend(50kg, 20% ethanol solution); (OO) Enzyme treatment(4L, pectinex 5 XL, 30~40°C, 12 hours); (PP) Cooling; (QQ) Fraction with a solvent(100kg, ethyl acetate, twice); (RR) Dehydrate(10kg, sodium sulfate anhydrous); (SS) Filter and concentrate by reduced pressure; (TT) Ethyl acetate extract(2.1kg); (UU) Diaion HP-20 column chromatography; (VV) Fraction with 40% ethanol solution; (WW) Fraction with 60% ethanol solution; (XX) Mulberry branch extract I(1.2kg); (YY) Mulberry branch extract II(110g)

Abstract translation: 目的：提供一种桑树枝提取物的制备方法，以产生大量具有抗炎和抗衰老作用的含有羟基维生素的纯化粉末，并使用反式西伐他汀和莫拉辛作为功能性食品和化妆品的新型材料。 构成：含有羟基维生素的桑树分枝提取物的制备方法，包括：蒸桑桑干1小时，干燥; 向100公斤干桑树中加入650公斤75-95％乙醇溶液，超声波在40-50℃下萃取12小时; 减压浓缩提取物; 将浓缩物溶解在80％乙醇溶液中并在室温下孵育; 除去沉淀，加正己烷，分馏; 去除上层油并浓缩下层; 向桑树脱脂乙醇提取物中加入20％乙醇溶液悬浮; 用10％果胶酶处理脱脂乙醇提取物，并在30-40℃下水解12小时，得到水解产物; 用乙酸乙酯溶剂分级水解产物，减压浓缩上层; 使用20％乙醇溶液溶解浓缩物，并吸附在悬浮HP-20吸附离子交换柱上; 用20％乙醇溶液洗涤所得物; 并用40％乙醇溶液洗脱所得物并浓缩。 （附图标记）（AA）干桑树枝（100kg）; （BB）CNCNF（650kg，80％乙醇溶液，超声波提取器，50℃，12小时，两次）; （CC）过滤器; （DD）过滤液体; （EE，LL）减压浓缩; （FF）桑树分支乙醇提取物（10kg）; （GG）再溶解（50kg，乙醇溶液）; （HH）昼夜孵化; （二）上清液; （JJ）脱脂（100kg，正己烷）; （KK）下层; （MM）桑叶脱乙醇提取物（8.5kg）; （NN）悬浮液（50kg，20％乙醇溶液）; （OO）酶处理（4L，pectinex 5 XL，30〜40℃，12小时）; （PP）冷却; （QQ）用溶剂（100kg，乙酸乙酯，2次）分级; （RR）脱水（10kg，无水硫酸钠）; （SS）通过减压过滤和浓缩; （TT）乙酸乙酯提取物（2.1kg）; （UU）Diaion HP-20柱色谱; （VV）用40％乙醇溶液分级; （WW）用60％乙醇溶液分级; （XX）桑树枝提取物I（1.2kg）; （YY）桑树枝提取物II（110g）