公开(公告)号：KR101371194B1

公开(公告)日：2014-03-12

申请号：KR1020120025594

申请日：2012-03-13

Applicant: 대구가톨릭대학교산학협력단 ,  (주)에스.앤.디

Inventor： 최상원 ,  김은옥 ,  조성희 ,  박은정

IPC: A61K31/404 ,  A61K36/815 ,  A61P3/00

Abstract: 본 발명은 구기자 뿌리껍질인 지골피(
Lycii Cortex Radicis , LCR)로부터 유래한 티라민 유도체(CT, FT)의 항콜레스테롤 효능에 관한 것으로, 지골피 유래의 티라민 유도체는 HMG-CoA 환원효소와 ACAT의 활성을 저해하고, 동물실험을 통하여 혈청 총콜레스테롤 감소효과 뿐만 아니라, 특히 LCR 페놀릭아마이드 FT는 잇꽃종자유래의 FS(
N- feruloylserotonin) 수준의 상기 효소저해 효과가 있고 페놀릭아마이드를 포함하는 LCR 추출물은 저농도에서도 잇꽃종자추출물 유래의 serotonin보다 혈청 콜레스테롤 수준을 감소시키는 뛰어난 효과가 있다

公开(公告)号：KR1020130104240A

公开(公告)日：2013-09-25

申请号：KR1020120025594

申请日：2012-03-13

Applicant: 대구가톨릭대학교산학협력단 ,  (주)에스.앤.디

Inventor： 최상원 ,  김은옥 ,  조성희 ,  박은정

IPC: A61K31/404 ,  A61K36/815 ,  A61P3/00

CPC classification number: A61K36/815 ,  A23V2200/326 ,  A61K2236/333

Abstract: PURPOSE: An anticholesterol composition is provided to suppress the activities of HMG-CoA reductase and acyl-CoA:cholesterol acyltransferase (ACAT) and to lower cholesterol in serum using a Lycii radicis cortex-derived tyramine derivative, thereby preventing hyperlipidemia. CONSTITUTION: A method for preparing an anticholesterol tyramine derivative comprises the steps of: extracting Lycii radicis cortex powder with an ethanol solution and filtering the extract; concentrating the extract by compression; and performing Sep-Pak C18 cartridges column chromatography. The derivative is trans-N-p-coumaroyltyramine (CT) or trans-N-feruloyltyramine (FT). A functional food composition for anticholesterol and antioxidative effects contains the tyramine derivative as an active ingredient.

Abstract translation: 目的：提供一种抗胆固醇组合物，以抑制HMG-CoA还原酶和酰基辅酶A：胆固醇酰基转移酶（ACAT）的活性，并使用雷公藤皮质衍生的酪胺衍生物降低血清中的胆固醇，从而预防高脂血症。 构成：制备抗胆固醇酪胺衍生物的方法，包括以下步骤：用乙醇溶液提取李子皮质粉末并过滤提取物; 通过压缩浓缩提取物; 并进行Sep-Pak C18柱色谱。 衍生物是反式-N-对 - 芳香酰酪氨酸（CT）或反式N-阿魏酰酪胺（FT）。 用于抗胆固醇和抗氧化作用的功能性食品组合物含有酪胺衍生物作为活性成分。

公开(公告)号：KR1020120119809A

公开(公告)日：2012-10-31

申请号：KR1020110038010

申请日：2011-04-22

Applicant: 대구가톨릭대학교산학협력단

Inventor： 최상원 ,  김은옥 ,  이유진

IPC: A23L21/10 ,  A23L19/00 ,  A23G3/48 ,  A21D13/08

CPC classification number: A23L21/10 ,  A23L5/10

Abstract: PURPOSE: Mulberry jam and a producing method thereof are provided to use high-quality mulberry syrup obtained from assorted mulberry to produce the jam. CONSTITUTION: A producing method of mulberry jam comprises the following steps: assorting and washing mulberry; mixing the washed mulberry and sugar in a weight ratio of 1:1; sealing, fermenting, and aging the mixture for 3-9 months, and filtering the mixture using a 20mesh sieve to obtain mulberry syrup; mixing the mulberry syrup with mulberry syrup flesh, and heating the mixture at 70 deg. C for 10 minutes before stirring; removing stems from the stirred mixture, and refining the mulberry syrup flesh; adding pectin to the refined mulberry syrup flesh; and coagulating the mixture before stopping the heating process and adding citric acid and vitamin C and sterilizing the mixture. [Reference numerals] (AA) Fresh mulberry; (BB) Dressing; (CC) Sugar-preserving; (DD) Sealed-aging; (EE) Filtering; (FF) Original mulberry jam flesh; (GG) Crushing; (HH) Stirring(removing stems); (II) Refining(mulberry jam flesh); (JJ) (fresh mulberry:sugar=1:1); (KK) (3-9 months); (LL) (sieve); (MM) Mulberry extract

Abstract translation: 目的：提供桑果果酱及其生产方法，以使用从各种桑树获得的优质桑果糖浆产生果酱。 构成：桑果果酱的生产方法包括以下步骤：桑树分类和洗涤; 以1：1的重量比混合洗涤的桑树和糖; 密封，发酵和熟化混合物3-9个月，并用20目筛过滤混合物，得到桑树浆; 将桑树浆与桑叶糖浆混合，并在70度加热混合物。 搅拌10分钟; 从搅拌的混合物中除去茎，并精制桑叶糖浆; 将果胶加入到精制桑叶浆中; 并在停止加热过程之前凝结混合物，并加入柠檬酸和维生素C并对混合物进行灭菌。 （附图标记）（AA）新鲜桑树; （BB）敷料; （CC）保糖; （DD）密封老化; （EE）过滤; （FF）原桑果果酱肉; （GG）粉碎; （HH）搅拌（去除茎）; （二）精炼（桑果果肉）; （JJ）（新鲜桑berry：糖= 1：1）; （KK）（3-9个月）; （LL）（筛）; （MM）桑树提取物

公开(公告)号：KR1020110121487A

公开(公告)日：2011-11-07

申请号：KR1020100041094

申请日：2010-04-30

Applicant: 대구가톨릭대학교산학협력단 ,  서미자

Inventor： 최상원 ,  김은옥 ,  임현희 ,  서미자

IPC: A61K36/14 ,  A61K36/264 ,  A61K8/97 ,  A61Q19/08

CPC classification number: A61K36/14

Abstract: PURPOSE: An oriental medicine material extract containing eugenol derivatives and a method for preparing the same are provided to ensure antioxidation, anti-aging, and anti-inflammation. CONSTITUTION: A method for preparing steam distillation extract of oriental medicine materials comprises: a step of drying herb medicines and adding distilled water; a step of adding ether and isolating with a steam distillation device; and a step of decompressing. A functional composition for antioxidation or antiaging contains the extract as an active ingredient. A functional composition for anti-inflammation contains the extract as an active ingredient. The extract contains eugenol derivatives as an active ingredient. The eugenol derivative is methyleugenol or acetyleugenol.

Abstract translation: 目的：提供含有丁子香酚衍生物的东方药物提取物及其制备方法，以确保抗氧化，抗衰老和抗炎。 构成：东方药材蒸汽蒸馏提取物的制备方法，包括：草药干燥，加入蒸馏水的步骤; 加入乙醚并用蒸汽蒸馏装置分离的步骤; 和解压缩的一个步骤。 用于抗氧化或抗衰老的功能组合物含有提取物作为活性成分。 用于抗炎的功能组合物含有提取物作为活性成分。 提取物含有丁子香酚衍生物作为活性成分。 丁子香酚衍生物是甲基丁烯醇或乙酰丁烯醇。

公开(公告)号：KR1020090067273A

公开(公告)日：2009-06-25

申请号：KR1020070134845

申请日：2007-12-21

Applicant: 대구가톨릭대학교산학협력단

Inventor： 최상원 ,  김은옥 ,  오지혜

IPC: A23L1/223 ,  A23L1/221 ,  A23L1/325 ,  A23L1/326

CPC classification number: A23L27/14 ,  A23L17/00 ,  A23L17/10

Abstract: An enzyme-treated seasoning and a preparation method thereof are provided to improve solubility, digestibility and preference while maintaining the functionality and nutrients of natural ingredients through extrusion molding and enzymatic treatment. A method for preparing an enzyme-treated seasoning comprises the following steps of: performing a first extraction molding; fermenting the first-extrusion molded material with an enzyme solution; performing a second extrusion molding; drying the second-extrusion molded material in a hot air drier until the moisture content becomes 5% or less; pulverizing the dried material 200-250 mesh in size; and collecting the pulverized material by a cyclone. The seasoning composition consists of 55wt% of freeze-dried shrimp, 5wt% of anchovy, 5wt% of sea tangle, 5wt% of pyogo mushroom, 5wt% of garlic, 2wt% of bean sprouts, 2wt% of radish, 2wt% of onion, 2wt% of ginger, 1wt% of Alaska Pollack, 1wt% of bonito, 1wt% of sea mussel, 1wt% of cuttlefish, 1wt% of sesame, 1wt% of Korean leek, 1wt% of red pepper and 10wt% of salicornia herbacea.

Abstract translation: 提供酶处理的调味料及其制备方法以通过挤出成型和酶处理来保持天然成分的功能和营养，从而提高溶解性，消化率和偏好。 制备酶处理调味料的方法包括以下步骤：进行第一次提取成型; 用酶溶液发酵第一挤出成型材料; 进行第二挤压成型; 在热空气干燥器中干燥第二挤出成型材料直到水分含量变为5％以下; 粉碎尺寸为200-250目的干燥材料; 并通过旋风收集粉碎物料。 调味成分由冻干虾55％，an鱼5％，海螯虾5％，py菇5％，大蒜5％，豆芽2％，萝卜2％，洋葱2％ ，2重量％的姜，1重量％的bon鱼，1重量％的bon鱼，1重量％的贻贝，1重量％的墨鱼，1重量％的芝麻，1重量％的韩国韭菜，1重量％的红辣椒和10重量％的水ia草 。

公开(公告)号：KR1020120119189A

公开(公告)日：2012-10-30

申请号：KR1020110036997

申请日：2011-04-20

Applicant: 대구가톨릭대학교산학협력단 ,  서미자

Inventor： 서미자 ,  최상원 ,  김은옥 ,  이유진

IPC: C07D311/30 ,  C07C65/10 ,  A61K36/605 ,  A61P39/06

Abstract: PURPOSE: A manufacturing method of mulberry seed originated polyphenol compound is provided to enhance antioxidant function, thereby being useful for cosmestic material. CONSTITUTION: A polyphenol compound is one of compounds having chemical structure 1-11 which are originated from mulberry seed. An isolation refining method of the polyphenol compound comprises the following steps: obtaining mulberry seed oil and defatted meal by compressing the mulberry seed; organic solvent extracting degatted meal; and silica-gel, sephadex LH-20, ODS-A column chromatographing ethyl acetate fraction. The functional food for antioxidant contains mulberry seed originated polyphenol compound.

Abstract translation: 目的：提供桑树种子起源的多酚化合物的制造方法，以增强抗氧化功能，从而可用于美容材料。 构成：多酚化合物是起源于桑树种子的具有化学结构1-11的化合物之一。 多酚化合物的分离精制方法包括以下步骤：通过压缩桑树种子获得桑树籽油和脱脂粉; 有机溶剂提取脱盐粉; 和硅胶，sephadex LH-20，ODS-A柱层析乙酸乙酯级分。 抗氧化功能性食品含有桑树种子起源于多酚化合物。

公开(公告)号：KR1020130093372A

公开(公告)日：2013-08-22

申请号：KR1020120014928

申请日：2012-02-14

Applicant: 대구가톨릭대학교산학협력단 ,  최상원

Inventor： 최상원 ,  김은옥 ,  임현희

IPC: A61K36/605 ,  A61K36/60 ,  A61K31/045 ,  A61K31/05

CPC classification number: A61K8/97 ,  A61K36/605 ,  A61K2236/10 ,  A61K2236/19 ,  A61K2236/33 ,  A61Q19/02 ,  A61Q19/08 ,  Y10S514/844 ,  Y10S514/857

Abstract: PURPOSE: A method for preparing a mulberry branch extract is provided to produce a large amount of purified powder containing oxyresveratrol with anti-inflammatory and antiaging functions and to use trans-rasveratrol and moracin as a novel material for functional foods and cosmetic products. CONSTITUTION: A method for preparing a mulberry branch extract containing oxyresveratrol comprises the steps of: steaming mulberry branches for one hour and drying; adding 650 kg of a 75-95% ethanol solution to 100 kg of the dried mulberry branches and extracting by ultrasonic wave at 40-50°C for 12 hours; concentrating the extract by reduced pressure; dissolving the concentrate in a 80% ethanol solution and incubating at room temperature; removing precipitate, adding normal-hexane, and fractioning; removing an upper layer oil and concentrating the lower layer; adding a 20% ethanol solution to the defatted ethanol extract of mulberry branches and suspending; treating the defatted ethanol extract with 10% pectinase and hydrolyzing at 30-40°C for 12 hours to obtain a hydrolysate; fractioning the hydrolysate with an ethyl acetate solvent and concentrating the upper layer by reduced pressure; dissolving the concentrate using the 20% ethanol solution and adsorbing onto diaion HP-20 adsorption ion exchange column; washing the resultant with the 20% ethanol solution; and eluting the resultant with a 40% ethanol solution and concentrating. [Reference numerals] (AA) Dried mulberry branches(100kg); (BB) CNCNF(650kg, 80% ethanol solution, ultrasonic extractor, 50°C, 12 hours, twice); (CC) Filter; (DD) Filtered liquid; (EE, LL) Concentrate by reduced pressure; (FF) Ethanol extract of the mulberry branches(10kg); (GG) Re-dissolve(50kg, ethanol solution); (HH) Incubate day and night; (II) Supernatant; (JJ) Defatting(100kg, normal-hexane); (KK) Lower layer; (MM) Defatted ethanol extract of mulberry branches(8.5kg); (NN) Suspend(50kg, 20% ethanol solution); (OO) Enzyme treatment(4L, pectinex 5 XL, 30~40°C, 12 hours); (PP) Cooling; (QQ) Fraction with a solvent(100kg, ethyl acetate, twice); (RR) Dehydrate(10kg, sodium sulfate anhydrous); (SS) Filter and concentrate by reduced pressure; (TT) Ethyl acetate extract(2.1kg); (UU) Diaion HP-20 column chromatography; (VV) Fraction with 40% ethanol solution; (WW) Fraction with 60% ethanol solution; (XX) Mulberry branch extract I(1.2kg); (YY) Mulberry branch extract II(110g)

Abstract translation: 目的：提供一种桑树枝提取物的制备方法，以产生大量具有抗炎和抗衰老作用的含有羟基维生素的纯化粉末，并使用反式西伐他汀和莫拉辛作为功能性食品和化妆品的新型材料。 构成：含有羟基维生素的桑树分枝提取物的制备方法，包括：蒸桑桑干1小时，干燥; 向100公斤干桑树中加入650公斤75-95％乙醇溶液，超声波在40-50℃下萃取12小时; 减压浓缩提取物; 将浓缩物溶解在80％乙醇溶液中并在室温下孵育; 除去沉淀，加正己烷，分馏; 去除上层油并浓缩下层; 向桑树脱脂乙醇提取物中加入20％乙醇溶液悬浮; 用10％果胶酶处理脱脂乙醇提取物，并在30-40℃下水解12小时，得到水解产物; 用乙酸乙酯溶剂分级水解产物，减压浓缩上层; 使用20％乙醇溶液溶解浓缩物，并吸附在悬浮HP-20吸附离子交换柱上; 用20％乙醇溶液洗涤所得物; 并用40％乙醇溶液洗脱所得物并浓缩。 （附图标记）（AA）干桑树枝（100kg）; （BB）CNCNF（650kg，80％乙醇溶液，超声波提取器，50℃，12小时，两次）; （CC）过滤器; （DD）过滤液体; （EE，LL）减压浓缩; （FF）桑树分支乙醇提取物（10kg）; （GG）再溶解（50kg，乙醇溶液）; （HH）昼夜孵化; （二）上清液; （JJ）脱脂（100kg，正己烷）; （KK）下层; （MM）桑叶脱乙醇提取物（8.5kg）; （NN）悬浮液（50kg，20％乙醇溶液）; （OO）酶处理（4L，pectinex 5 XL，30〜40℃，12小时）; （PP）冷却; （QQ）用溶剂（100kg，乙酸乙酯，2次）分级; （RR）脱水（10kg，无水硫酸钠）; （SS）通过减压过滤和浓缩; （TT）乙酸乙酯提取物（2.1kg）; （UU）Diaion HP-20柱色谱; （VV）用40％乙醇溶液分级; （WW）用60％乙醇溶液分级; （XX）桑树枝提取物I（1.2kg）; （YY）桑树枝提取物II（110g）

公开(公告)号：KR1020130000114A

公开(公告)日：2013-01-02

申请号：KR1020110060606

申请日：2011-06-22

Applicant: 서미자 ,  대구가톨릭대학교산학협력단

Inventor： 서미자 ,  최상원 ,  김은옥 ,  임현희

IPC: A61K36/234 ,  A61K36/232 ,  A61P29/00

Abstract: PURPOSE: An herbal mist for treating inflammation using a steam distilled extract of various medicinal herbs is provided to ensure excellent antioxidative and anti-inflammatory effects. CONSTITUTION: A cosmetic composition for preventing and treating skin inflammatory diseases contains a volatile perfume ingredient as an active ingredient, contained in a steam distilled extract of Cnidium officinale Makino and Angelica gigas Nakai. The volatile perfume ingredient is eugenol and acetyl eugenol. A health functional food and a cosmetic composition for preventing or treating skin inflammatory diseases contain the extract as an active ingredient. A functional cosmetic composition for antioxidation or anti-aging contains the extract as an active ingredient. [Reference numerals] (AA) Naturally drying medicinal herbs; (BB) Maturing in a traditional pot; (CC) Heating in a heating tank; (DD) Distillation in a distillation facility; (EE) Cooling in a cooling tank; (FF) Storing in a storage tank; (GG) Packaging in a container; (HH) Products

Abstract translation: 目的：提供使用各种药草蒸汽蒸馏提取物治疗炎症的草药雾，以确保优异的抗氧化和抗炎作用。 构成：用于预防和治疗皮肤炎性疾病的化妆品组合物含有作为活性成分的挥发性香料成分，其包含在C ale Mak a a a a a distilled distilled distilled。。。。。 挥发性香料成分是丁子香酚和乙酰丁香酚。 用于预防或治疗皮肤炎性疾病的健康功能食品和化妆品组合物含有提取物作为活性成分。 用于抗氧化或抗衰老的功能性化妆品组合物含有提取物作为活性成分。 [参考号]（AA）天然干草药; （BB）成熟在传统的锅; （CC）在加热罐中加热; （DD）蒸馏设备中的蒸馏; （EE）冷却箱中的冷却; （FF）储存在储罐中; （GG）包装在容器中; （HH）产品

公开(公告)号：KR101438543B1

公开(公告)日：2014-09-18

申请号：KR1020120014928

申请日：2012-02-14

Applicant: 대구가톨릭대학교산학협력단 ,  최상원

Inventor： 최상원 ,  김은옥 ,  임현희

IPC: A61K36/605 ,  A61K36/60 ,  A61K31/045 ,  A61K31/05

Abstract: 본 발명은 항염증 및 항노화성 옥시레스베라트롤, 트란스-레스베라트롤 및 모라신 함유 뽕나무가지(상지)추출물의 제조방법에 관한 것으로, 상지를 찜처리한 후 건조하고 80% 에탄올수용액으로 추출하여 얻은 에탄올추출물을 pectinex 효소처리한 후 에틸아세테이트로 분획하고 농축한 후 최종 다이아이온 HP-20 흡착이온수지 칼럼 크로마토그래피를 실시하여 항염증성 및 항노화성 옥시레스베라트롤 (oxyresveratrol), 트란스-레스베라트롤(
trans -resveratrol) 및 모라신(moracin)을 함유하는 상지추출물을 제조하고, 이의 피부 염증 치료제 및 피부미백 기능성화장품 신소재용도를 개시한다.

公开(公告)号：KR101340081B1

公开(公告)日：2013-12-11

申请号：KR1020120014927

申请日：2012-02-14

Applicant: 대구가톨릭대학교산학협력단 ,  최상원

Inventor： 최상원 ,  김은옥 ,  이원정

IPC: A23L1/30 ,  A61K8/97

Abstract: 본 발명은 고혈압 뿐만 아니라 당뇨, 피부노화 억제용 플라보노이드 함유 뽕나무잎(상엽)추출물의 제조방법에 관한 것으로, 건조 상엽을 30% 에탄올수용액으로 추출하여 얻은 에탄올추출물을 다이아이온 HP-20 흡착이온수지 칼럼 크로마토그래피를 실시하여 항고혈압, 항당뇨 및 항노화성 퀘세틴 3-
O -(6"-
O -말로닐)-베타-디-글루코사이드(Q3MG) 및 캄페롤 3-
O -(6"-
O -말로닐)-베타-디-글루코사이드(K3MG)를 함유한 상엽추출물 I과 루틴(rutin, RT), 이소퀘시트린(isoquercitrin, IQT) 및 아스트라갈린(astragalin, AG)을 함유한 상엽추출물 Ⅱ를 제조하고 이를 이용하여 상엽으로부터 항고혈압, 항당뇨 및 항노화성 퀘세틴 및 캄페롤유도체를 대량생산과 고혈압, 당뇨 및 피부미백 기능성식품 및 화장품의 신소재의 용도를 개시한다.