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公开(公告)号:WO2014098438A1
公开(公告)日:2014-06-26
申请号:PCT/KR2013/011715
申请日:2013-12-17
Applicant: 대한민국(농촌진흥청장)
CPC classification number: C12N15/8243 , A23L7/196 , A23L33/105 , A23V2002/00 , A61K31/05 , A61K36/899 , C12N9/1029 , C12N15/8257 , C12Y203/01095
Abstract: 본 발명은 천연형 벼의 12번째 염색체에 레스베라트롤 합성(resveratrol synthase) 유전자가 발현가능하게 삽입되어, 고농도의 레스베라트롤을 생합성하는 벼 및 이로부터 생산되는 쌀에 관한 것이다. 또한, 본 발명은 천연형 벼의 12번째 염색체에 레스베라트롤 합성(resveratrol synthase) 유전자가 발현가능하게 삽입되어, 고농도의 레스베라트롤을 생합성하는 벼로부터 얻어지는 쌀을 포함하는 대사성 질환 예방 및 개선용 건강기능 식품 조성물, 동물 사료 조성물 및 약학적 조성물에 관한 것이다. 본 발명의 레스베라트롤 생성효소를 삽입한 고농도의 레스베라트롤 함유하는 벼로부터 생산되는 쌀은 단순 동량의 레스베라트롤을 섭취하였을 때보다 월등히 우수한 효과를 지니고 있다. 또한, 별도의 레스베라트롤을 분리·추출하는 과정없이 바로 식품으로 사용할 수 있는 쌀이라는 형태로 생산됨에 따라 대사성 질환 기능성 예방 및 개선용 식품, 사료 및 의약품으로 널리 이용될 수 있다.
Abstract translation: 本发明涉及将白藜芦醇合酶表达性插入天然无壳稻的第十二染色体以生物合成白藜芦醇的高浓度的无细米,以及从未经脱壳的稻生产的米。 此外,本发明涉及一种健康功能食品组合物,用于动物饲料的组合物和用于预防和减少代谢疾病的药物组合物,所述组合物包括从未经脱壳的水稻获得的水稻,其中白藜芦醇合酶可表达地插入到第十二染色体 天然无壳大米生物合成高浓度白藜芦醇。 含有白藜芦醇高浓度白藜芦醇的无ed米产生的米与简单摄取相同量的白藜芦醇相比显示出优异的效果。 此外,由于白藜芦醇以水稻的形式生产,其可以直接用于食品而不进行分离和提取,所以白藜芦醇可广泛用于食品,饲料和医疗用品,并且用于预防和改善代谢疾病。
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公开(公告)号:KR1020030001659A
公开(公告)日:2003-01-08
申请号:KR1020010036463
申请日:2001-06-26
Applicant: 대한민국(농촌진흥청장)
Abstract: PURPOSE: An extract of Protaetia brevitarsis which has almost the same liver protecting effect as silymarin as a conventional liver disease treating agent is provided which can be effectively used as an effective ingredient for a liver disease treating agent or health supplementary agent. CONSTITUTION: Distilled water is added to larvae powder of Protaetia brevitarsis and extracted and the extract is passed through a dialysis membrane to produce a Protaetia brevitarsis extract having a molecular weight of 1,000 or less. The extract is formulated to be administered in a dose of 1 to 2,500mg/kg/day, preferably 10 to 500mg/kg/day and can recover the liver effectively when hepatotoxicity is induced by drugs such as carbon dioxide.
Abstract translation: 目的:提供与常规肝脏疾病治疗剂几乎与水飞蓟素相同的肝保护作用的红曲霉提取物,其可以有效地用作肝脏疾病治疗剂或健康补充剂的有效成分。 构成:将蒸馏水加入到短白茅的幼虫粉末中,萃取,将提取物通过透析膜,制成分子量为1000以下的短叶提取物。 将提取物配制成以1-2500mg / kg /天,优选10-500mg / kg /天的剂量施用,并且当药物如二氧化碳诱导肝毒性时,可以有效地回收肝脏。
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公开(公告)号:KR100315168B1
公开(公告)日:2001-11-30
申请号:KR1019990002672
申请日:1999-01-28
Applicant: 대한민국(농촌진흥청장)
Abstract: 본발명은신규한창상피복재및 그의제조방법에관한것으로, 더욱구체적으로는실크단백질을구성하는펩타이드중 피브로인단백질용액을급속동결건조하여스폰지막의형태로제조하는것에의해생체적합성, 막의일부가녹아들어가창상면과밀착하는특성, 수분투과력, 피부재생능력등이우수한창상피복재를제공하는것에관한것이다.
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公开(公告)号:KR1020010016895A
公开(公告)日:2001-03-05
申请号:KR1019990032108
申请日:1999-08-05
Applicant: 대한민국(농촌진흥청장) , 홍영식품 주식회사
IPC: A23G9/04
CPC classification number: A23G9/42
Abstract: PURPOSE: A method for preparing a kind of ice cream containing powdered mulberry leaves and optionally milk fat is provided to serve low-caloric ice cream products having unique flavor, color and texture and preventing geriatric diseases. CONSTITUTION: The ice cream product containing milk fat is prepared by the steps of: (i) dipping mulberry leaves into an aqueous solution of sodium bicarbonate for 5sec and pulverizing the leaves to fine powder of 100-300mesh; (ii) leaving mulberry leaves in an airtight space filled with nitrogen gas, drying and washing the leaves before grinding the processed leaves to fine powder and adding to the mulberry leaf powder above in a ratio of 1:1; (iii) mixing 18-35wt% of raw cream, 7-11wt% of powdered nonfat milk, 4-7wt% of ice sugar, 0-3wt% of hydrous crystalline dextrose, 0.2-0.6wt% of emulsion stabilizer, 0-0.2wt% of vanilla, 0-0.05wt% of refined salt, 9-13wt% of refined sugar and refined water at 40-90deg.C for 10-60min; (iv) homogenizing and sterilizing the mixture at 70-100deg.C for 10-60sec before cooling and adding to 0.1-5wt% of the powdered mulberry leaves; and then (v) aging the mixed mulberry leaf powder at 1-10deg.C for 1-20hr and increasing the quantity of the aged to 50-150 times and frozen mixture before packing the resulting product. The ice cream not containing milk fat comprises 0.1-5wt% of the powdered mulberry leaves, 9-12wt% of powdered nonfat milk, 9.5-12% of coconut hardened oil, 4-8wt% of ice sugar, 0-4wt% of hydrous crystalline dextrose, 0.2-0.6wt% of emulsion stabilizer, 0-0.2wt% of vanilla, 0-0.05wt% of refined salt, and refined water. The emulsion stabilizer includes 22.5% of guar gum, 19.5% of locust bean gum, 4.5% of carrageenan, 3.5% of Tamarind gum and 50% of Glycerin fatty acid ester.
Abstract translation: 目的:提供一种制备含有桑叶和任选的乳脂的冰淇淋的方法,用于提供具有独特风味,色泽和质感的低热量冰淇淋产品,并防止老年病。 构成:含有乳脂的冰淇淋产品是通过以下步骤制备的:(i)将桑叶浸入碳酸氢钠水溶液中5秒钟,粉碎至100-300目的细粉; (ii)将桑叶留在装有氮气的气密空间中,干燥和洗涤叶子,然后将加工的叶子研磨成细粉末,并以1:1的比例加入到上述桑叶粉末中; (iii)混合18-35重量%的生奶油,7-11重量%的粉状脱脂牛奶,4-7重量%的冰糖,0-3重量%的含水结晶葡萄糖,0.2-0.6重量%的乳化稳定剂,0-0.2 重量百分比的香草,0-0.05重量%的精制盐,9-13重量%的精制糖和精制水在40-90℃下进行10-60分钟; (iv)将混合物在70-100℃均化灭菌10-60秒,然后冷却,加入0.1-5重量%的桑叶粉末; 然后(v)将混合的桑叶粉末在1-10℃下老化1-20小时,并将包装所得产物的老化量增加到50-150倍,冷冻混合物。 不含乳脂的冰淇淋含有0.1-5重量%的桑叶粉,9-12重量%粉末脱脂奶,9.5-12%椰子硬化油,4-8重量%冰糖,0-4重量%含水量 结晶葡萄糖,0.2-0.6重量%的乳化稳定剂,0-0.2重量%的香草,0-0.05重量%的精制盐和精制水。 乳化稳定剂包括22.5%的瓜尔胶,19.5%的刺槐豆胶,4.5%的角叉菜胶,3.5%的罗望子胶和50%的甘油脂肪酸酯。
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公开(公告)号:KR101742029B1
公开(公告)日:2017-06-01
申请号:KR1020150158412
申请日:2015-11-11
Applicant: 가천대학교 산학협력단 , 대한민국(농촌진흥청장)
Abstract: 본발명은레스베라트롤생합성발아현미를유효성분으로하는조성물에관한것이다. 특히, 상기본 발명은콜라겐분해에관여하는효소인 MMP-1의활성억제및 콜라겐합성에관여하는효소인 type I procollagen의활성을증가시키는효과를가지는레스베라트롤생합성발아현미를유효성분으로포함하는피부노화및 피부주름개선또는치료용약학적조성물에관한것이다. 본발명의레스베라트롤생합성발아현미를유효성분으로포함하는조성물은피부노화및 피부주름개선예방또는치료용약학적조성물, 식품조성물, 의약외품조성물및 피부미백용화장료조성물을포함한다양한제품에유용하게사용될수 있다
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公开(公告)号:KR101594969B1
公开(公告)日:2016-02-18
申请号:KR1020130157626
申请日:2013-12-17
Applicant: 대한민국(농촌진흥청장)
CPC classification number: C12N15/8243 , A23L7/196 , A23L33/105 , A23V2002/00 , A61K31/05 , A61K36/899 , C12N9/1029 , C12N15/8257 , C12Y203/01095
Abstract: 본발명은천연형벼의 12번째염색체에레스베라트롤합성(resveratrol synthase) 유전자가발현가능하게삽입되어, 고농도의레스베라트롤을생합성하는벼 및이로부터생산되는쌀에관한것이다. 또한, 본발명은천연형벼의 12번째염색체에레스베라트롤합성(resveratrol synthase) 유전자가발현가능하게삽입되어, 고농도의레스베라트롤을생합성하는벼로부터얻어지는쌀을포함하는대사성질환예방및 개선용건강기능식품조성물, 동물사료조성물및 약학적조성물에관한것이다. 본발명의레스베라트롤생성효소를삽입한고농도의레스베라트롤함유하는벼로부터생산되는쌀은단순동량의레스베라트롤을섭취하였을때보다월등히우수한효과를지니고있다. 또한, 별도의레스베라트롤을분리·추출하는과정없이바로식품으로사용할수 있는쌀이라는형태로생산됨에따라대사성질환기능성예방및 개선용식품, 사료및 의약품으로널리이용될수 있다.
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公开(公告)号:KR100414187B1
公开(公告)日:2004-01-07
申请号:KR1020010036463
申请日:2001-06-26
Applicant: 대한민국(농촌진흥청장)
Abstract: PURPOSE: An extract of Protaetia brevitarsis which has almost the same liver protecting effect as silymarin as a conventional liver disease treating agent is provided which can be effectively used as an effective ingredient for a liver disease treating agent or health supplementary agent. CONSTITUTION: Distilled water is added to larvae powder of Protaetia brevitarsis and extracted and the extract is passed through a dialysis membrane to produce a Protaetia brevitarsis extract having a molecular weight of 1,000 or less. The extract is formulated to be administered in a dose of 1 to 2,500mg/kg/day, preferably 10 to 500mg/kg/day and can recover the liver effectively when hepatotoxicity is induced by drugs such as carbon dioxide.
Abstract translation: 目的:提供一种与常规肝脏疾病治疗剂具有几乎与水飞蓟素相同的肝脏保护作用的紫薇球茎提取物,其可以有效地用作肝病治疗剂或保健补充剂的有效成分。 组成:将蒸馏水加入到短尾叶蝉幼虫粉末中并提取,并将提取物通过透析膜,以产生分子量为1,000或更低的Protaetia brevitarsis提取物。 提取物配制为以1至2,500mg / kg /天,优选10至500mg / kg /天的剂量施用,并且当由诸如二氧化碳的药物诱导肝毒性时可以有效地回收肝脏。
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公开(公告)号:KR1020020019715A
公开(公告)日:2002-03-13
申请号:KR1020000052723
申请日:2000-09-06
Applicant: 대한민국(농촌진흥청장)
IPC: A61L15/22
CPC classification number: A61L15/22 , A61F2013/51019 , A61F2013/51047 , C08L1/02
Abstract: PURPOSE: Provided is an antibiotic sanitary fabric produced of silk yarn and cellulose separated from waste milk packs, which can be used for various application, as a covering and has antibiotic activity effects. CONSTITUTION: The fabric is made of silk yarn which is prepared by purifying waste silk and cellulose which are separated from waste milk packs. The fabric is produced by carrying out a method comprising steps of (i) preparing silk yarn by purifying waste silk; (ii) preparing cellulose by treating waste milk packs; and (iii) mixing the silk yarn prepared from the step (i) and the cellulose prepared from the step (ii) to form an antibiotic sanitary fabric. The mixing ratio of cellulose to silk yarn is about 1:0.3.
Abstract translation: 目的:提供一种抗生素卫生织物,由丝线和纤维素分离而成,可用于各种应用,作为覆盖物,具有抗菌活性。 规定:织物由丝绸制成,通过净化与废牛奶包分离的废丝和纤维素制备。 该织物是通过以下步骤制造的:(i)通过净化废丝来制备丝线; (ii)通过处理废奶包来制备纤维素; 和(iii)将由步骤(i)制备的丝线和由步骤(ii)制备的纤维素混合以形成抗生素卫生织物。 纤维素与丝线的混合比约为1:0.3。
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公开(公告)号:KR1019990074787A
公开(公告)日:1999-10-05
申请号:KR1019980008600
申请日:1998-03-14
Applicant: 대한민국(농촌진흥청장)
IPC: C12P21/06
Abstract: 본 발명은 실크피브로인을 단백질 분해효소로 분해한 펩타이드의 제조에 관한것이다. 실크(견사)를 효소분해하여 견단백질인 피브로인을 얻고 이를 염화칼슘과 에탄올에 반응시켜 투석하여 얻은 용액에 단백질 분해효소인 플라보자임(flavourzyme) 및 액티나제(actinase)로 분해하여 동결건조한 후 분말상의 피브로인 펩타이드를 제조하였다. 이들 펩타이드는 분자량이 12,000 - 13,000이고 중합도가 163으로서 pH 1 - 13에서 70% 용해도를 나타내고 있으므로 체내 흡수율이 높아 항산화작용과 알콜대사분해능력이 탁월하여 기능성 식품 또는 의약품으로 사용과 각 성분에 대한 순수 활성물질의 개발에 기여할 수 있다.
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公开(公告)号:KR101986008B1
公开(公告)日:2019-06-05
申请号:KR1020170077947
申请日:2017-06-20
Applicant: 가천대학교 산학협력단 , 대한민국(농촌진흥청장) , 순천대학교 산학협력단
IPC: A61K31/05 , A61K36/899 , A61K8/9794 , A61K8/34 , A23L33/105 , A61P17/00 , A61Q19/00 , A61Q5/02 , A61Q1/14
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