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公开(公告)号：KR1020100064512A
公开(公告)日：2010-06-15
申请号：KR1020080122989
申请日：2008-12-05
Applicant: 대한민국 (식품의약품안전처장)
IPC: A61K31/4745 , A61P25/30
CPC classification number: A61K31/4745
Abstract: PURPOSE: A therapeutic agent for drug abuse containing L-tetrahydropalmatine(L-THP) is provided to suppress drug abuse cause by drug administration. CONSTITUTION: A therapeutic agent for drug abuse contains L-tetrahydropalmatine(L-THP) as an active ingredient and pharmaceutically acceptable carrier. The L-THP is isolated from Corydalis ochotensis TURCZ. The therapeutic agent effectively suppresses drug dependence by serotonins or morphines. The morphines include amorphine.
Abstract translation: 目的：提供含有L-四氢化他汀（L-THP）的药物滥用治疗剂，以抑制药物滥用引起的药物滥用。 构成：药物滥用治疗剂含有作为活性成分的L-四氢化他汀（L-THP）和药学上可接受的载体。 L-THP分离自紫堇（Corydalis ochotensis TURCZ）。 治疗剂有效地抑制了血清素或吗啡的药物依赖性。 吗啡包括吗啡。
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公开(公告)号：KR1020090083254A
公开(公告)日：2009-08-03
申请号：KR1020080009293
申请日：2008-01-29
Applicant: 대한민국 (식품의약품안전처장)
CPC classification number: G01N33/5008 , C12Q1/6844 , C12Q2600/136 , C12Q2600/158 , G01N2500/00
Abstract: A method for predicting the side effect of candidate drug on a cardiac myocyte is provided to develop a drug without side effect by easily verifying side effect of candidate drug. A method for predicting side effect of candidate drug on a heart comprises: a step of preparing an experimental group in which the candidate drug is treated to a cardiac myocyte and control group in which nothing is treated; a step of measuring expression of Gadd45beta gene in cardiac myocyte in experimental and control group; and a step of determining the possibility of damage.
Abstract translation: 提供了一种用于预测候选药物对心肌细胞的副作用的方法，通过容易地验证候选药物的副作用，开发出无副作用的药物。 用于预测候选药物对心脏的副作用的方法包括：制备将候选药物治疗至心肌细胞的实验组和不治疗任何物质的对照组的步骤; 在实验组和对照组中测量心肌细胞中Gadd45beta基因表达的步骤; 并确定损坏的可能性的步骤。
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公开(公告)号：KR101054093B1
公开(公告)日：2011-08-09
申请号：KR1020080122989
申请日：2008-12-05
Applicant: 대한민국 (식품의약품안전처장)
IPC: A61K31/4745 , A61P25/30
Abstract: 본 발명은 L-테트라하이드로팔마틴(L-tetrahydropalmatine, L-THP)을 유효성분으로 하고, 약제학적으로 허용되는 담체를 포함하는 약물남용 치료제에 관한 것이다. 본 발명의 L-THP를 유효성분으로 하는 약물남용 치료제는 마약성 진통제 또는 마약의 투여에 의하여 형성되는 약물 의존성을 유의적으로 억제할 수 있으므로, 약물남용의 치료에 널리 활용될 수 있을 것이다.
약물남용, 약물의존성, L-테트라하이드로팔마틴(L-THP)Abstract translation: 本发明涉及包含L-四氢巴马汀（L-THP）作为活性成分和药学上可接受的载体的药物滥用治疗剂。 由于药物滥用治疗本发明作为活性成分，能够抑制由麻醉性镇痛药或麻醉药给药显著形成药物依赖的L-THP，它将被广泛用于药物滥用的治疗。
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