公开(公告)号：KR1020090083254A

公开(公告)日：2009-08-03

申请号：KR1020080009293

申请日：2008-01-29

Applicant: 대한민국 (식품의약품안전처장)

Inventor： 정이숙 ,  김미영 ,  서은지 ,  이동하 ,  조혜영 ,  정은용 ,  최기환 ,  김혜수 ,  민홍기

IPC: C12Q1/68 ,  C12N15/00

CPC classification number: G01N33/5008 ,  C12Q1/6844 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N2500/00

Abstract: A method for predicting the side effect of candidate drug on a cardiac myocyte is provided to develop a drug without side effect by easily verifying side effect of candidate drug. A method for predicting side effect of candidate drug on a heart comprises: a step of preparing an experimental group in which the candidate drug is treated to a cardiac myocyte and control group in which nothing is treated; a step of measuring expression of Gadd45beta gene in cardiac myocyte in experimental and control group; and a step of determining the possibility of damage.

Abstract translation: 提供了一种用于预测候选药物对心肌细胞的副作用的方法，通过容易地验证候选药物的副作用，开发出无副作用的药物。 用于预测候选药物对心脏的副作用的方法包括：制备将候选药物治疗至心肌细胞的实验组和不治疗任何物质的对照组的步骤; 在实验组和对照组中测量心肌细胞中Gadd45beta基因表达的步骤; 并确定损坏的可能性的步骤。