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公开(公告)号：KR1020160043463A
公开(公告)日：2016-04-21
申请号：KR1020140137889
申请日：2014-10-13
Applicant: 아주대학교산학협력단
CPC classification number: C12N5/0607 , A61K35/12 , G01N33/15
Abstract: 본발명은물리화학적나노구조체를이용한유도만능줄기세포(induced pluripotent stem cell; iPS cell)의제조방법에관한것으로, 보다상세하게는나노구조체의물리화학적자극에의해체세포또는성체줄기세포를포함하는포유류세포를역분화시켜유도만능줄기세포를제조하는방법, 상기방법을이용하여제조된유도만능줄기세포및 상기유도만능줄기세포를포함하는세포치료제에관한것이다. 본발명의나노구조체를이용한체세포또는성체줄기세포를포함하는포유류세포를역분화시켜유도만능줄기세포를제조하는방법은외래전사인자(transcription factor)의도입없이나노구조체에존재하는물리화학적자극을이용하여보다효과적이고안전하게유도만능줄기세포를제조할수 있는효과가있다.
Abstract translation: 本发明涉及使用物理化学纳米结构产生诱导多能干细胞（iPS细胞）的方法，更具体地涉及通过物理化学刺激将包括体细胞或成体干细胞在内的哺乳动物细胞去分化来诱导多能干细胞的方法 纳米结构，诱导使用该方法产生的多能干细胞，以及包括诱导多能干细胞的细胞治疗剂。 通过使用纳米结构去分化哺乳动物细胞（包括体细胞或成体干细胞）来产生诱导多能干细胞的方法使用存在于纳米结构中的物理化学刺激，而不引入外源转录因子，因此可以安全有效地产生诱导的多能干细胞 。
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公开(公告)号：KR101100409B1
公开(公告)日：2011-12-30
申请号：KR1020090067469
申请日：2009-07-23
Applicant: 한국기계연구원 , 아주대학교산학협력단
Abstract: 본 발명의 일 실시예에 따른 탄소나노튜브 기반의 이종접합 구조체 제조방법은, 기저층 상에 탄소나노튜브 이차원 구조체를 형성하는 단계, 및 상기 탄소나노튜브 이차원 구조체 표면 상에 전이금속 또는 반도체성 물질의 일차원 구조체를 형성하는 단계를 포함한다.
탄소나노튜브, 이종접합, 산화아연-
公开(公告)号：KR1020110009985A
公开(公告)日：2011-01-31
申请号：KR1020090067469
申请日：2009-07-23
Applicant: 한국기계연구원 , 아주대학교산학협력단
CPC classification number: C01B32/16 , B82B1/00 , B82B3/0009 , C01B32/18 , C01B2202/08
Abstract: PURPOSE: A method for preparing a carbon nanotube-based hybride structure is provided to obtain hybrid structure having various nanorods containing zinc oxide without a catalyst. CONSTITUTION: A method for preparing a carbon nanotube-based hybrid structure comprises: a step of forming a two-dimensional structure(15) on a substrate(10) by Langmuir-Blodgett technique; and a step of forming a one-dimensional structure of transition metal or semiconductive material on the two-dimensional structure surface by chemical vapor deposition. The one-dimensional structure is nanodot(17), nanowire, or nanorod(20).
Abstract translation: 目的：提供一种制备基于碳纳米管的混合结构的方法，以获得具有不含催化剂的含有氧化锌的各种纳米棒的混合结构。 构成：制备基于碳纳米管的混合结构的方法包括：通过Langmuir-Blodgett技术在基底（10）上形成二维结构（15）的步骤; 以及通过化学气相沉积在二维结构表面上形成过渡金属或半导体材料的一维结构的步骤。 一维结构是纳米点（17），纳米线或纳米棒（20）。
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4.发明公开
公开(公告)号：KR1020140024025A
公开(公告)日：2014-02-27
申请号：KR1020140009076
申请日：2014-01-24
Applicant: 아주대학교산학협력단
Abstract: The present invention relates to a method for manufacturing patterned substrates which patterns a substrate with a carbon nanotube Langmuir-Blodgett (LB) thin film using a micro contact printing method or a lift-off method, and to growth and differentiation control of stem cells using the same. By using the present invention: manufacturing can be simply completed by attaching and detaching a mold; patterns can be formed on curved surfaces so that patterns can be formed on various shaped substrates; and various shaped patterns can be formed so that the method for manufacturing patterned substrates can be applied in various industries. In addition, the present invention controls growth and differentiation of the stem cells through patterning of the carbon nanotube LB thin film so that the stem cells can be grew in short time and differentiation can be enhanced. [Reference numerals] (AA) Barrier; (BB) Carbon nanotube; (CC) Water; (DD) Transfer carbon nanotube LB thin film to PDMS mold; (EE) PDMS mold; (FF) Carbon nanotube; (GG) Heat at 80°C for 5 minutes after attaching on a substrate; (HH) Substrate; (II) Remove mold; (JJ) Carbon nanotube LB thinfilm pattern; (KK) Transfer the carbon nanotube LB thin film to the substrate; (LL) Carbon nanotube LB thin film; (MM) Heat at 80°C for 5 minutes after attaching the PDMS mold to the thin film; (NN) Remove mold
Abstract translation: 本发明涉及使用微接触印刷法或剥离法利用碳纳米管Langmuir-Blodgett（LB）薄膜对基板进行图案化的图案化基板的制造方法，以及使用 一样。 通过使用本发明：可以通过附接和分离模具简单地完成制造; 可以在弯曲表面上形成图案，使得可以在各种成形基板上形成图案; 并且可以形成各种形状的图案，使得用于制造图案化基板的方法可以应用于各种行业。 此外，本发明通过图案化碳纳米管LB薄膜来控制干细胞的生长和分化，使得干细胞可以在短时间内生长并且可以增强分化。 （附图标记）（AA）屏障; （BB）碳纳米管; （CC）水; （DD）将碳纳米管LB薄膜转移至PDMS模具; （EE）PDMS模具; （FF）碳纳米管; （GG）附着在基板上80℃加热5分钟; （HH）基板; （二）去除模具; （JJ）碳纳米管LB薄膜图案; （KK）将碳纳米管LB薄膜转移到基板上; （LL）碳纳米管LB薄膜; （MM）将PDMS模具附着在薄膜上之后，在80℃下加热5分钟; （NN）去除模具
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公开(公告)号：KR1020110129178A
公开(公告)日：2011-12-01
申请号：KR1020100048660
申请日：2010-05-25
Applicant: 아주대학교산학협력단
CPC classification number: C01B32/158 , B82Y30/00 , B82Y40/00 , C01B32/16 , H01L27/115
Abstract: PURPOSE: An n-acetylated chitosan-carbon nano-tube complex and a method for manufacturing the same are provided to individualize the complex and to improve the bio compatibility of the complex by applying carbon nano-tube to n-acetylated chitosan. CONSTITUTION: In an n-acetylated chitosan-carbon nano-tube complex, an n-acetylated chitosan is non-covalently bonded with carbon nano-tube. The diameter of the n-acetylated chitosan-carbon nano-tube complex is less than or equal to 10nm. A method for manufacturing the n-acetylated chitosan-carbon nano-tube complex includes the following: Carbon nano-tube is introduced into an N-acetylated chitosan aqueous solution, and an ultrasonic wave is applied to the solution. A centrifugation process is further implemented after the ultrasonic wave applying process. The centrifugation process is implemented at 1000-5000RPM for 3-10 hours. The complex is individualized by the centrifugation process.
Abstract translation: 目的：提供正乙酰化的壳聚糖 - 碳纳米管复合物及其制备方法，以使复合物个体化，并通过将碳纳米管应用于正乙酰化壳聚糖来提高复合物的生物相容性。 构成：在正乙酰化壳聚糖 - 碳纳米管络合物中，正乙酰化壳聚糖与碳纳米管非共价键合。 正乙酰化壳聚糖 - 碳纳米管络合物的直径小于或等于10nm。 制造正乙酰化壳聚糖 - 碳纳米管络合物的方法包括：将碳纳米管引入N-乙酰化壳聚糖水溶液中，并向该溶液施加超声波。 在超声波施加处理之后进一步实现离心处理。 离心过程在1000-5000RPM下进行3-10小时。 复合物通过离心过程个性化。
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Patent Agency Ranking
公开(公告)号：KR101267218B1
公开(公告)日：2013-05-23
申请号：KR1020090116493
申请日：2009-11-30
Applicant: 아주대학교산학협력단
Inventor： 김재호 , 임정혁 , 이재혁 , NajeebC.K.
IPC: B82B1/00
Abstract: 본발명에의하여수용액상의탄소노나노튜브분산용액, 계면활성제및 폴리에틸렌이민을포함하는탄소나노튜브-고분자복합체가개시되며, 탄소나노튜브를기판에패터닝하기위한준비단계로써폴리에틸렌아민을사용하여탄소나노튜브-고분자복합체용액을준비하는단계; 상기탄소나노튜브-고분자복합체용액을 AFM 탐침표면에물리적흡착을유도하는단계; 상기탄소나노튜브-고분자복합체용액이함침된 AFM 탐침을기판상에서이동시키며탄소나노튜브-고분자복합체를전사하는단계; 상기전사된탄소나노튜브-고분자복합체에서고분자부분을화학적처리를통해제거하는단계; 및소자를형성하여전도성을확인하는단계를포함하는탄소나노튜브의패터닝방법이개시된다.
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公开(公告)号：KR1020110060000A
公开(公告)日：2011-06-08
申请号：KR1020090116465
申请日：2009-11-30
Applicant: 아주대학교산학협력단
CPC classification number: C12M25/02 , C01B32/15 , C12N5/0696 , C12N11/02
Abstract: PURPOSE: A support for culturing stem cells is provided to control stem cell growth form and speed and to differentiate special cells. CONSTITUTION: A method for controlling proliferation and differentiation of stem cell comprises a step of controlling network structure CNT membrane thickness and surface roughness of CNT membrane using more than 0.5 ml of carbon nanotube solution dispersed in an organic solvent. The stem cell is mesenchymal stem cells(3).
Abstract translation: 目的：提供培养干细胞的支持，以控制干细胞生长形式和速度，并区分特殊细胞。 构成：用于控制干细胞增殖和分化的方法包括使用分散在有机溶剂中的0.5ml以上的碳纳米管溶液来控制CNT膜厚度和CNT膜的表面粗糙度的步骤。 干细胞是间充质干细胞（3）。
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公开(公告)号：KR101242391B1
公开(公告)日：2013-03-12
申请号：KR1020100048660
申请日：2010-05-25
Applicant: 아주대학교산학협력단
Abstract: 본 발명은 N-아세틸레이티드 키토산에 탄소나노튜브를 적용하여 생체적합성이 뛰어나며 탄소나노튜브의 직경 10 nm이하에서 개별화가 이루어진 N-아세틸레이티드 키토산-탄소나노튜브 및 이를 제조하는 방법에 관한 것으로서 더불어 상기 N-아세틸레이티드 키토산-탄소나노튜브 복합체를 전자소자에 적용하여 p-type의 반도체성 소자 특성을 가지는 소자 제작방법에 관한 것이다.
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公开(公告)号：KR101171774B1
公开(公告)日：2012-08-06
申请号：KR1020090116465
申请日：2009-11-30
Applicant: 아주대학교산학협력단
Abstract: 줄기세포를 배양하는 지지체가 개시된다. 본 발명에 따른 망상구조체 탄소나노튜브 박막을 지지체로 사용하여 줄기세포를 성장 및 분화시키는 방법과 탄소나노튜브의 막 두께와 표면 거칠기를 조절하여 줄기세포의 성장 및 분화를 조절하고, 막 두께와 표면 거칠기를 조절하여 성장 및 분화시키는 줄기세포의 개체수를 조절하고, 상기 요소들을 포함하는 배양 지지체에 관한 것이다.
탄소나노튜브, 중간엽 줄기세포, 랭뮤어-블로젯 방법-
10.发明公开
公开(公告)号：KR1020110129364A
公开(公告)日：2011-12-01
申请号：KR1020110049772
申请日：2011-05-25
Applicant: 아주대학교산학협력단
IPC: B82B3/00 , H01L21/027
CPC classification number: B82B3/0004 , B82B3/0009 , G03F7/165 , H01L21/0274
Abstract: PURPOSE: A method for forming patterns using a carbon nano-tube langmuir-blodgett(LB) thin film and the growth and differentiation control of stem cells using the same are provided to pattern the carbon nano-tube LB thin film on a substrate using a micro-contact printing method or a lift-off method. CONSTITUTION: A method for forming patterns using a carbon nano-tube LB thin film includes the following: A carbon nano-tube LB thin film is patterned on a substrate using a micro-contact printing method or a lift-off method. The micro-contact printing method transfers the carbon nano-tube LB thin film to a patterned mold. The transferred thin film is in contact with a substrate in order to transfer the patterned thin film to the substrate. The lift-off method transfers entire carbon nano-tube LB thin film to the substrate and to a patterned mold. The transferred thin film is lifted off from the substrate. Stem cells are cultivated on the patterns of the substrate.
Abstract translation: 目的：提供一种使用碳纳米管薄膜（LB）薄膜形成图案的方法，并使用该方法对使用其的干细胞进行生长和分化控制，以使用碳纳米管LB薄膜 微接触印刷法或剥离法。 构成：使用碳纳米管LB薄膜形成图案的方法包括以下：使用微接触印刷法或剥离法将碳纳米管LB薄膜图案化在基板上。 微接触印刷法将碳纳米管LB薄膜转印到图案化的模具上。 转印的薄膜与基底接触，以将图案化的薄膜转移到基底上。 剥离方法将整个碳纳米管LB薄膜转移到基底和图案化的模具上。 将转移的薄膜从衬底上提起。 干细胞在基质的图案上培养。
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