Abstract:
PURPOSE: An Id1 protein for preventing or treating fibrosis is provided to relieve symptom due to collagen synthesis and to reduce collagen expression induced by TGF-beta 1/Smad 2,3. CONSTITUTION: A pharmaceutical composition for preventing or treating fibrosis contains Id1(inhibitory of DNA binding 1) protein or a polynucleotide encoding the protein as an active ingredient. The protein is Id1-v2 having an amino acid sequence of sequence number 1. A polynucleotide encoding the protein has a base of sequence number 2. An expression vector contains the polynucleotide. The expression vector is a retrovirus vector or adenovirus vector. A method for screening a candidate material for preventing or treating fibrosis comprises: a step of contacting a candidate material to Id1 protein or a recombinant cells expressing the protein; a step of measuring Id1 protein level and activation or gene expression level; and a step of determining the candidate material is the material for preventing or treating fibrosis in case of the expression level and activation is increased over a control group.
Abstract:
A composition for skin external preparation, which contains colostrums as an active ingredient is provided to improve skin condition by having anti-alergic effect, anti-inflammatory effect, promotion effect of keratin differentiation, and skin moisturization. A composition of skin external preparation comprises 0.001-30 weight% of colostrums based on the total weight as an active ingredient. The composition has the effect of anti-allergy, anti-inflammation, keratin differentiation, skin moisturization, skin barrier strengthening, improvement of wrinkle care. The composition comprises only colostrums, or further comprises excipient, diluents, or anti-oxidant. The composition is used in a form of skin softener, lotion, nutrition cream, spray, granule, essence, powder, syrup, liquid, aerosol, ointment, suspension, capsule, or pill. The excipient is used by mixing with glycerin, starch, water, alcohol, propylene glycol, or saline solution.